<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21109

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTAAANWVANGASLEDCHSNLFSLAELTGIKWRRYNFGGHGDCGPIISAPAQDDPILLSFIRCLQANLLCVWRRDVKPDCKELWIFWWGDEPNLVGVIHHELQVVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFVRPYEKDEKPVNKSEHLSCAFTFFLHGESNVCTSVEIAQHQPIYLINEEHIHMAQSSPAPFQVLVSPYGLNGTLTGQAYKMSDPATRKLIEEWQYFYPMVLKKKEELKEEEELGYDDDFPVAVEVIVGGVRMVYPSAFVLISQNDLPVPQSVAGTGGHITVGQQGLGSVKDPSNCGMPLTPPTSPEQAVIGESGGTQSAVSHLGSQDGGMITMHSPKRSGKIPPKLHNHMVHRVWKECILNRTQSKRSQMSTPTLEEEPANNPATWDFVDPTQRVSCSCSRHKLLKRCAVGPSRPPTISQPGFSAGPSSSSSLPPPASSKHKTTERQEKGDKLQKRPLIPFHHRPSVAEELCMEQDPPGQKLGLAGIDSSLEVASSRKYDKQMAVPSRNTSKQMNLNPMDSPHSPISPLPPTLSPQPRGQETENLDPPSVPVNPALYGNGLELQQLSTLDDRTVLVGQRLPLMAEVSETALYCGIRPSNPESSDKWWHSYHLPSIDDAEFRPPELQGERCDAKMEVNSESTALQRLLAQPNKRFKIWQDKQPQMQPLHFLDPLPLSQQPGDSLGEVNDPYTFEDGDIKYIFTANKKCKQGTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPEGKNAMSLFSSTKTDVRQDSAAGRAGSSSLTQVTDLAPSLHDLDNIFDNSDDDELGAVSPALRSSKMPTVGTEDRPLGKDGRAAVPYPPIADLQRMFPTPPSLEQHPAFSPVMNYKDGISSETVTALGMMESPMVSMVSTQLTEFKVEVEDGLGSPKPEEIKDFSYVHKVPTLQPFVGSSMFAPLKMLPSQCLLPLKIPDACLFRPSWAIPPKIEQLPMPPAATFIRDGYNNVPSVGSLADPDYLNTPQMNTPVTLNSAAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQPIPEAHSLYVTLILSDSVMNIFKDRNFDSCCICACNMNIKGADVGLYIPDSSNEDQYRCTCGFSAIMNRKLGYNSGLFLEDELDIFGKNSDIGQAAERRLMMCQTTFLPQMEGARKSQEPPISLLLLLQNQHTQPFASLSFLDYISCNNRQTLPCVSWSYDRVQADNNDYWTECFNALEQGRQYVDNPTGGKVDEALVRSATVHSWPHSNVLDISMLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGTYGSEESPEPLPIPTLLVGYDKDFLTISPFSLPFWERLLLDPYGGHRDVAYIVVCPENEALLEGAKTFFRDLSAVYEMCRLGQHKPICKVLRDGIMRVGKTVAQKLAEELVSEWFNQPWGSEESDNHSRLKLYAQVCRHHLAPYLATLQLDSSLLIPPKYQTPPAAAQGQATPGNAGPLASNPGSAAPSAGSAFNPTSNGSSVNLAASSSASGSSVPPASTSASAPIINQISTTSSSGFSGSVGAQNPSAGASSAERTQGNIGCGGDTEPGQSSSQPSQDGQESVTERERIGIPTEPDSADSQAYPPAVVIYMVDPFTYTAEEDSTSGNFWLLSLMRCYTEMLDNLPEHMRNSFILQIVPCQYMLQTMKDEQVFYIQYLKSMAFSVYCQCRRPLPTQIHIKSLTGFGPAASIEMTLKNPERPSPIQLYSPPFILAPIKDKQTELGETFGEASQKYNVLFVGYCLSHDQRWLLASCTDLHGELLETCIVNIALPNRSRRSKVSARKIGLQKLWEWCIGIVQMTSLPWRVVIGRLGRLGHGELKDWSILLGECSLQTISKRLKDVCRMCGISAADSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNMQSSQLNTPQDASCTHILVFPTSSTIQVAPANYPNEDGFSPNNDDMFVDLPFPDDMDNDIGILMTGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQAQNQCPLFLKASLHHHISVAQTDELLPARNSQRVPHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRTSCLPVHFVVLTQLYNAIMNIL
Length2209
PositionMiddle
OrganismDelphinapterus leucas (Beluga whale)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Whippomorpha> Cetacea> Odontoceti> Monodontidae> Delphinapterus.
Aromaticity0.07
Grand average of hydropathy-0.374
Instability index58.23
Isoelectric point5.63
Molecular weight242660.06
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21109
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.93|      26|      28|    2067|    2094|       1
---------------------------------------------------------------------------
 2067- 2094 (37.05/32.80)	GsHFQhSRSQGERL...LSREAPEELKQQPL
 2097- 2125 (44.88/28.56)	G.YFV.STAKAENLpqwFWSSCPQAQNQCPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     119.87|      27|      28|    1008|    1034|       2
---------------------------------------------------------------------------
 1008- 1034 (48.71/22.82)	PDYLNTPQMNTPVTLNSAAPASNSGAG
 1039- 1062 (44.66/20.27)	P...ATPRFSVPTPRTPRTPRTPRGGG
 1078- 1096 (26.51/ 8.86)	GSPASTPSTTRP..LNSVEPA......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.13|      20|      28|    1130|    1156|       3
---------------------------------------------------------------------------
 1130- 1149 (40.30/41.25)	CICACNMNIK.GADVGLYIPD
 1160- 1180 (33.83/16.30)	CGFSAIMNRKlGYNSGLFLED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.78|      16|      17|    1232|    1248|       4
---------------------------------------------------------------------------
 1232- 1248 (26.97/19.82)	TQPFASLSFlDYISC.NN
 1251- 1267 (27.81/15.51)	TLPCVSWSY.DRVQAdNN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      97.23|      20|      20|    1608|    1627|       5
---------------------------------------------------------------------------
 1548- 1567 (33.34/14.54)	SNPGSAAPSAGSAFNPTSN.G
 1608- 1627 (34.58/15.37)	GSVGAQNPSAGASSAERTQ.G
 1630- 1648 (29.31/11.83)	GCGGDTEP..GQSSSQPSQdG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.32|      11|      26|     541|     551|       6
---------------------------------------------------------------------------
  541-  551 (23.11/10.69)	NLNPMDSPHSP
  570-  580 (22.21/ 9.94)	NLDPPSVPVNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.16|      17|      20|     937|     955|       7
---------------------------------------------------------------------------
  939-  955 (31.49/17.17)	LQPF..VGSSMFAPLKMLP
  959-  977 (28.67/ 8.92)	LLPLkiPDACLFRPSWAIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.55|      20|      20|    1686|    1705|       8
---------------------------------------------------------------------------
 1686- 1705 (37.01/21.77)	YTAEEDSTSG...NFWLLSLMRC
 1706- 1728 (31.54/17.44)	YTEMLDNLPEhmrNSFILQIVPC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.51|      14|      20|    1374|    1387|      10
---------------------------------------------------------------------------
 1374- 1387 (27.59/14.27)	SPEPLPI..PTLLVGY
 1395- 1410 (22.92/10.42)	SPFSLPFweRLLLDPY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.07|      18|      28|    2018|    2040|      12
---------------------------------------------------------------------------
 2018- 2040 (24.82/24.75)	SPNNDdmfvDLPFPDDmDNDIGI
 2049- 2066 (34.25/16.73)	SPNSS....PVPSPGS.PSGIGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     236.88|      74|    1264|     156|     235|      13
---------------------------------------------------------------------------
  156-  235 (112.41/88.76)	PVNKSeHLSCAFTFFlHGESNVCTSVEIAQHQPIYLINEEHIHMAQSSPAP..FQVLVSPYgLNGTLtGQayKMSDPATR.KL
 1423- 1499 (124.47/74.52)	PENEA.LLEGAKTFF.RDLSAVYEMCRLGQHKPICKVLRDGIMRVGKTVAQklAEELVSEW.FNQPW.GS..EESDNHSRlKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     206.06|      66|      70|     796|     865|      14
---------------------------------------------------------------------------
  796-  865 (103.21/69.60)	LTQVTDLAPSLHDLDNIfDNSDDDELGAV.SPALrsSKMPTVGTEDRPLGKDGRAAvPYP.PIADLQRM..FPT
  869-  938 (102.86/56.31)	LEQHPAFSPVMNYKDGI.SSETVTALGMMeSPMV..SMVSTQLTEFKVEVEDGLGS.PKPeEIKDFSYVhkVPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.44|      11|      16|     603|     614|      15
---------------------------------------------------------------------------
  603-  614 (15.05/11.39)	GQRlPLMAEVSE
  620-  630 (20.39/10.62)	GIR.PSNPESSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.01|      26|      28|     363|     390|      16
---------------------------------------------------------------------------
  363-  390 (43.33/38.16)	KRSGKIPPKLHNHMVHR..VWKecILNRTQ
  392-  419 (42.69/29.01)	KRSQMSTPTLEEEPANNpaTWD..FVDPTQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21109 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) APSLHDLDNIFDNSDDDELGAVSPALRSSKMPTVGTEDRPLGKDGRAAV
2) CAVGPSRPPTISQPGFSAGPSSSSSLPPPASSKHKTTERQEKGDKLQKRPLIPFHHRPSVAEELCMEQDPPGQKLGLAGIDSSLEVASSRKYDKQMAVPSRNTSKQMNLNPMDSPHSPISPLPPTLSPQPRGQETENLDPPSVPVNPALYG
3) ECILNRTQSKRSQMSTPTLEEEPANNPATWDFVDPT
4) GILMTGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPE
5) GTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPEGKNAMSLFSSTKTDVRQDSAAGRAGSSSLTQVTD
6) KYQTPPAAAQGQATPGNAGPLASNPGSAAPSAGSAFNPTSNGSSVNLAASSSASGSSVPPASTSASAPIINQISTTSSSGFSGSVGAQNPSAGASSAERTQGNIGCGGDTEPGQSSSQPSQDGQESVTERERIGIPTEPDSA
7) SVAGTGGHITVGQQGLGSVKDPSNCGMPLTPPTSPEQAVIGESGGTQSAVSHLGSQDGGMITMHSPKRSGKIPPKLH
8) VGSLADPDYLNTPQMNTPVTLNSAAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQ
803
434
383
2039
736
1526
297
1002
851
584
418
2087
801
1667
373
1099










Molecular Recognition Features






MoRF SequenceStartStop




1) RFKIW
679
683