<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21099

Description mediator of RNA polymerase II transcription subunit 25 isoform X2
SequenceMVPGSEGPARAGGLVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSSAYEFVTWLDGIKFMGGGGESCSLIAEGLSTALQLFDDFRKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGCTTETLVQKIGERGIYFSIVSPRKLPALRLLFEKAAPPAMLEPLQPPADVSQDPRHMVLVRGLVLPVGGGSAPGPLQPKQPVPLPPAPPSGATLSAAPQQPLPPVPQQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPISPLQQAAPGVGPPYSQAQAPPLPPGPPGAPKPPPASQPSLVSTVASGPGLAPPAQPGAPSMAGTVAPGGVSGPSPAQLGAPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLDSLKGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHKQVQQQKLEQQRGMGAQQAPPGLGPILEDQARPSQNLLQLRPPQPQPQGTVGASTAAGQPQPQGAAQAPPGAPQGPPGAAPGPPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQGLGQPQLGPPLLHPPPPAQSWPAQLPPRAPLPGQMLLSGGPRGPVPQPGLQPSVMEDDILMDLI
Length747
PositionUnknown
OrganismDelphinapterus leucas (Beluga whale)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Whippomorpha> Cetacea> Odontoceti> Monodontidae> Delphinapterus.
Aromaticity0.05
Grand average of hydropathy-0.243
Instability index60.57
Isoelectric point8.72
Molecular weight78184.96
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21099
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.68|      25|      29|     653|     680|       2
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  615-  639 (46.65/10.08)	GA.PQ......GPPGAAPGPPPPGPILRP.QNP
  640-  672 (38.03/10.51)	GAnPQlrslllNPPPPQTGVPPPQASLHHlQPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     401.60|      69|     285|     385|     453|       3
---------------------------------------------------------------------------
  224-  283 (63.97/15.13)	..RGLvlpvGGG.SA....PGPLQ............P...KQPVPLPPAPPSGA.TLSA.....A.PqqPLPPVPQQYQV.PG.N.......LSAAQV.........
  385-  453 (113.38/33.35)	GAPAL....GGQQSV....SNKLL............A...WSGVLEWQEKPKPA.SVDA.....NTK..LTRSLPCQVYVNHGEN.......LKTEQWPQKLIMQLI
  462-  526 (61.31/14.15)	G.PLF....RNSRMVqfhfTNKDLdslkglyrimgnG...FAGCVHF...PHTA....................PCEVRVLML.........LYSSK..KKIFMGLI
  554-  595 (59.62/13.53)	QQRGM....GAQQAP....P................G...LGPILEDQARP........sqnllQLR..PPQPQP............................QGTV
  673-  747 (103.32/29.64)	GAPAL.......LPP....PHQGL............GqpqLGPPLLHP..PPPAqSWPA.....QLP..PRAPLPGQMLLSGGPRgpvpqpgLQPSVMEDDILMDLI
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21099 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GGSAPGPLQPKQPVPLPPAPPSGATLSAAPQQPLPPVPQQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPISPLQQAAPGVGPPYSQAQAPPLPPGPPGAPKPPPASQPSLVSTVASGPGLAPPAQPGAPSMAGTVAPGGVSGPSPAQLGAPALG
2) HKQVQQQKLEQQRGMGAQQAPPGLGPILEDQARPSQNLLQLRPPQPQPQGTVGASTAAGQPQPQGAAQAPPGAPQGPPGAAPGPPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQGLGQPQLGPPLLHPPPPAQSWPAQLPPRAPLPGQMLLSGGPRGPVPQPGLQPSVMEDDILMD
232
544
390
745










Molecular Recognition Features






MoRF SequenceStartStop




NANANA