<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21097

Description mediator of RNA polymerase II transcription subunit 12-like protein isoform X6
SequenceMAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSARNIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDLAGNKPLAILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQATDPNLEWTQISTRYLREQLAKISDFYHLASSAGDGPVPVPPDVEQAMRQWEYNEKLAFHMFQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCARRLALLLSDGPNLLAAHSPHMMIGPNSSGIGAPSPGPPGPGMSPVQLAFSDFLSCAQHGPLVYGLSCMLQTVTLCCPSALVWNYSTNDNKSANPGSPLDLLQVAPSSLPMPGGNTAFNQQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSMETLYHKIFWANQNKDNQEAAPSDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERCGESEVLDEKESISSASLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSITASTRPRSPAGENADEHYAKDHDVKMEEQTIMAHMGIDSGTTNIFDEVDKSDFKTDFGSEFPIFSPVPGESCENANPSLGRRMSVNGEKLLKREKPRELIFPSNYDLLRHLQYATHFPIPLDESSSHEYNQRTILLYGVGKEREEARHQLKKITKDILKILNKKSTTETGVGDEGQKARKSKQEAFPTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVIPANSNLRWDPDFMMDFIENPSARSINYSMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACLLPQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGSNNVGSLKNDDFTMRGLRRDGSADDIWTASQNSKSCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSADLNNNSSNSGMGLFNPNGIGSTDTSSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLLEGQKNPAPLSWAWFGTVRVDRKVIKYEEQHHLLLYHTHPMPKPRSYYLEPLPLPPEEEEEGPTSPISQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKSSSRVDEYPQSNMYRVPPNYSPVSSQMMHHPQSTLWGYNLVGQPQQPGLFLQSQALTPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAVMQPPSLHAITSQQQLIQMKLLQQQQQQRLLRQAQTRPFQQGQPGDQAALFAAQARPSPQLPQYPGLQQAQTMPQGYTMYGTQMPLQQTPQQQAGSVVLSPTYNSRTYPAAHSNPALMERLRQMQQQPPSGYVQQQASPYLQPLSGSQRLNHQSLQQSPLVGGGLDAVLTSVHPNLPSVSLSQDPVRPRQPQVRQQQRLLQMQQPQQSSQPQGQTLGLQTMQPQQPLFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTPYGHPSHF
Length2171
PositionKinase
OrganismDelphinapterus leucas (Beluga whale)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Whippomorpha> Cetacea> Odontoceti> Monodontidae> Delphinapterus.
Aromaticity0.07
Grand average of hydropathy-0.416
Instability index55.68
Isoelectric point7.50
Molecular weight242363.21
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21097
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     379.57|      80|      83|    1993|    2075|       1
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 1820- 1908 (73.65/25.97)	Y......P..QSN...MYRVppnyspvsSQMMHHPQStlwGYnlVGQ.PQQPglFLQ....SQ............ALTP..GGsrLDPAGSFVPTN...............tkQAlsnmlqrrsGAVMQPPSLH
 1909- 2004 (97.37/42.48)	........AITSQQQLIQ.M........KLLQQQQQQ...RL..LRQaQTRP..FQQGQPGDQaALFAAQAR.PSPQLPqyPG..LQQAQT..MPQgytmygtqmplqqtpqqQA.........GSVVLSPTYN
 2008- 2075 (116.18/48.49)	Y......PAAHSNPALMERL........RQMQQQPPS...GY..VQQ.QASP..YLQPLSGSQ.RLNHQSLQ.QSPLVG..GG..LDAVLTSVHPN......................................
 2078- 2135 (62.50/22.51)	SvslsqdPVRPRQPQVRQQQ........RLLQMQQP..........Q.QSS.....QP.QG.Q.TLGLQTMQpQQPLFP.rQG..LQQ..............................................
 2136- 2168 (29.87/ 6.71)	T......QQQQQTAAL...V........RQLQKQLSS...NQ..PQQ.GVTP..YGHP............................................................................
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     168.52|      65|      84|     432|     503|       2
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  387-  494 (78.23/85.68)	DNKSANPGSpldllqvapsslpmpggntafnqqvrariyeveqqiKQRG..RAVEVRWSFDKCQestAGVTISRVLHTlEVLDRHcfdRTDSSNSMETLYHKIFWANQNK
  495-  575 (90.29/70.26)	DNQEAAPSD......................eavvtllcewavscKRSGkhRAMAVAKLLEKRQ...AEIEAERCGES.EVLDEK...ESISSASLAGSSLPVFQNVLLR
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     128.10|      31|      83|     716|     746|       3
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  716-  746 (51.85/33.16)	GEKLLKREKPRELIFPSNYDLLRHLQYATHF
  770-  794 (29.76/15.75)	KE....REEARHQLKKITKDILKILNKKS..
  801-  831 (46.50/28.94)	GDEGQKARKSKQEAFPTLETVFTKLQLLSYF
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     559.79|     149|     153|    1120|    1271|       4
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  938- 1084 (176.19/100.48)	..........QVFeGLCGVVKH.VVNPS....ECSSPE..........RC.ILAYLYDLYVS...................................CsHLRSKFGDLF...SSACSKVKQTIYNNVIPANSNLRWDP......DFMMdfIENPSARSINysmLGKILSDNaanrysfvcntlmnVCM.GHQ.......DAGRINDIANFSSELTACCTVLSSEW
 1120- 1271 (242.31/149.70)	ATFIAILIARQCF.SLEDVVQH.VALPSLLaaACGDAD..AEPG.ARMTCRLLLHLFRAPQA...................................C.LLPQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLK......AIMM..LGDAKIGSNN...VGSLKNDD..............FTMrGLR.......RDGSADDIWTASQNSKSCGKSISIET
 1278- 1448 (141.29/79.06)	ARYVLRTICQQ.....EWVGEHcLKEPERL...CTDKEliLDPVlSNMQAQKLLQLICYPHGikectegdnlqrqhikrilqnleqwtlrqswlelqL.MIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSADLNnnssnsGMGL..FNPNGIGSTD...TSSTRQN...................GIKtflssseRRG....VW.................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     153.93|      52|      92|      71|     128|       5
---------------------------------------------------------------------------
   71-  120 (58.90/51.35)	............................................AYFSSILAEKLKLNTFQDTGKKKPQVNAKdnyWLvtaRSQSAIHSWFSDL
  121-  208 (69.03/42.87)	AGNKPLAIlakkvpilskkedvfaylakysvpmvratwlikmtcAYYSAISEAKIKKRQATDPNLEWTQISTR...YL...REQLAKISDFYHL
  212-  243 (26.00/ 9.37)	AGDGPVPV..............................ppdveqAMRQWEYNEKLAFHMFQE................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.11|      46|      83|    1533|    1588|       6
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 1533- 1582 (73.73/72.54)	LSNW..........................REERYqDdiKARQM...............MHEALQLRLNLVGGmFDTV......QRST.QWTTDWALL
 1620- 1713 (46.38/22.60)	LSNAspggseenkraymnlvkklkkelgdkRSESI.D..KVRQLlplpkqtcdvitcepMGSLIDTKGNKIAG.FDSIdkkqglQVSTkQKVSPWDLL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21097 with Med12 domain of Kingdom Metazoa
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