<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21095

Description mediator of RNA polymerase II transcription subunit 25 isoform X1
SequenceMVPGSEGPARAGGLVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSSAYEFVTWLDGIKFMGGGGESCSLIAEGLSTALQLFDDFRKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGCTTETLVQKIGERGIYFSIVSPRKLPALRLLFEKAAPPAMLEPLQPPADVSQDPRHMVLVRGLVLPVGGGSAPGPLQPKQPVPLPPAPPSGATLSAAPQQPLPPVPQQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPISPLQQAAPGVGPPYSQAQAPPLPPGPPGAPKPPPASQPSLVSTVASGPGLAPPAQPGAPSMAGTVAPGGVSGPSPAQLGAPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLDSLKGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHKQVQQQKLEQQRGMGAQQAPPGLGPILEDQARPSQNLLQLRPPQPQPQGTVGASTAAGQPQPQGAAQAPPGAPQGPPGAAPGPPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQGLGQPQLGPPLLHPPPPAQSWPAQLPPRAPLPVAKRKREREGHVFREKWERAYFFVEVKSMPTCLICKKIVSVLKEYNLRRHYESKHSKSFDQYTEQTRDAILNELKKGLKCQ
Length796
PositionUnknown
OrganismDelphinapterus leucas (Beluga whale)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Whippomorpha> Cetacea> Odontoceti> Monodontidae> Delphinapterus.
Aromaticity0.06
Grand average of hydropathy-0.325
Instability index58.83
Isoelectric point9.29
Molecular weight84689.41
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21095
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     867.63|     228|     285|     144|     428|       1
---------------------------------------------------------------------------
   26-  265 (243.00/64.71)	..............................ANLGPYFEGLRK.HYLLPAIeyfngGPP.....AE...........TDFGGDYGG......TQYSLVvfNTVDCAP..ESYVQCHAPTssayefvtwLDGIKFMGG..GGESCSLIAEGL......................................stalqlfddfrkmreqigqthrvclLI.CNSPpYLLPAvesttysgcttETLVQKIGERGIYFSIVSPRK.LPALRLLFEKAappAMLEPLQPP.ADVSQDPRHmvlVRGLVLPVGGGSApGPLQPKQPV..P...................LPPAPPSGATLsaAPQQPL
  267-  532 (325.94/92.13)	PVPQQYQVPGNLSAAQvaaQNAVEaaknQKAGLGPRFSPISPlQQAAPGV.....GPPYSQAQAP...........PLPPGPPGAPkpPPASQPSLV..STVASGPGLAPPAQPGAPS.........MAGTVAPGGVSGPSPAQLGAPALGGQQSvsnkllawsgvlewqekpkpasvDANTKLtRSL...........................pCQV..YVNHG...........ENLKTEQWPQKLIMQLIPQQL.LTTLGPLFRNS...RMVQFHFTN.KDLDS.......LKGLYRIMGNGFA.GCVHFPHTA..PcevrvlmllysskkkifmgLIPYDQSG...........
  533-  714 (298.69/60.29)	FVNGIRQVITNHKQVQ...QQKLE....QQRGMGA........QQAPPGL.....GPILEDQARPsqnllqlrppqPQPQGTVGAS..TAAGQPQ..........PQGAAQAPPGAPQ...........G..PPGAAPGPPPP..G.PILRPQNP.......................GANPQL.RSL.........................LL.NPPP...................................PQTgVPPPQ.........ASLHHLQPPgAPALLPPPH....QGLGQP........QLGP..PLlhP...................PPPAQSWPAQL..PPRAPL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21095 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GGSAPGPLQPKQPVPLPPAPPSGATLSAAPQQPLPPVPQQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPISPLQQAAPGVGPPYSQAQAPPLPPGPPGAPKPPPASQPSLVSTVASGPGLAPPAQPGAPSMAGTVAPGGVSGPSPAQLGAPALG
2) HKQVQQQKLEQQRGMGAQQAPPGLGPILEDQARPSQNLLQLRPPQPQPQGTVGASTAAGQPQPQGAAQAPPGAPQGPPGAAPGPPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQGLGQPQLGPPLLHPPPPAQSWPAQLPPRAPLPVAKRKREREG
232
544
390
725










Molecular Recognition Features






MoRF SequenceStartStop




NANANA