<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21091

Description mediator of RNA polymerase II transcription subunit 12-like protein isoform X5
SequenceMAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSARNIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDLAGNKPLAILAKKELPLAKSGVPQVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQATDPNLEWTQISTRYLREQLAKISDFYHLASSAGDGPVPVPPDVEQAMRQWEYNEKLAFHMFQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCARRLALLLSDGPNLLAAHSPHMMIGPNSSGIGAPSPGPPGPGMSPVQLAFSDFLSCAQHGPLVYGLSCMLQTVTLCCPSALVWNYSTNDNKSANPGSPLDLLQVAPSSLPMPGGNTAFNQQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSMETLYHKIFWANQNKDNQEAAPSDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERCGESEVLDEKESISSASLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSITASTRPRSPAGENADEHYAKDHDVKMEEQTIMAHMGIDSGTTNIFDEVDKSDFKTDFGSEFPIFSPVPGESCENANPSLGRRMSVNGEKLLKREKPRELIFPSNYDLLRHLQYATHFPIPLDESSSHEYNQRTILLYGVGKEREEARHQLKKITKDILKILNKKSTTETGVGDEGQKARKSKQEAFPTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVIPANSNLRWDPDFMMDFIENPSARSINYSMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACLLPQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGSNNVGSLKNDDFTMRGLRRDGSADDIWTASQNSKSCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSADLNNNSSNSGMGLFNPNGIGSTDTSSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLLEGQKNPAPLSWAWFGTVRVDRKVIKYEEQHHLLLYHTHPMPKPRSYYLEPLPLPPEEEEEGPTSPISQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKSSSRVDEYPQSNMYRVPPNYSPVSSQMMHHPQSTLWGYNLVGQPQQPGLFLQSQALTPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAVMQPPSLHAITSQQQLIQMKLLQQQQQQRLLRQAQTRPFQQGQPGDQAALFAAQARPSPQLPQYPGLQQAQTMPQGYTMYGTQMPLQQTPQQQAGSVVLSPTYNSRTYPAAHSNPALMERLRQMQQQPPSGYVQQQASPYLQPLSGSQRLNHQSLQQSPLVGGGLDAVLTSVHPNLPSVSLSQDPVRPRQPQVRQQQRLLQMQQPQQSSQPQGQTLGLQTMQPQQPLFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTPYGHPSHF
Length2182
PositionKinase
OrganismDelphinapterus leucas (Beluga whale)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Whippomorpha> Cetacea> Odontoceti> Monodontidae> Delphinapterus.
Aromaticity0.07
Grand average of hydropathy-0.415
Instability index55.72
Isoelectric point7.50
Molecular weight243483.51
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21091
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     219.34|      33|      33|    1944|    1976|       1
---------------------------------------------------------------------------
 1784- 1832 (28.24/ 8.85)	EGPTSPISQ.EP..ERKSAELSDQgktttdeekktkgrkrkTKS..SS....................RVDEY...P
 1944- 1976 (63.24/29.84)	QAQTRPFQQGQP..GDQAALFAAQ.................ARP..SP....................QLPQY...P
 1980- 2012 (33.95/12.27)	QAQTMP..QGYTmyGTQMPL...Q.................QTP..QQ....................QAGSVvlsP
 2046- 2096 (31.41/10.75)	Q.QASPYLQPLS..GSQ.RLNHQS.................LQQ..SPlvgggldavltsvhpnlpsvSLSQD...P
 2116- 2140 (33.58/12.05)	.....PQQSSQP..QGQT..LGLQ.................TM...QP....................QQPLF...P
 2142- 2170 (28.92/ 9.25)	QG....LQQTQQ..QQQTAALVRQ.................LQKqlSS....................NQPQ.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     534.39|     154|     168|    1427|    1594|       2
---------------------------------------------------------------------------
 1303- 1416 (103.64/50.63)	.....................................................................GEHcLKEPERLCTDKEliLDPVLSNMQAQKLLQLI.....CYpHGIK..ECTEG..DNLQRQhIKRILQNleqwtlrqsWLE..LQLMIK..QCLKDPGSGSVAEMNNLLDNI...AKATievfQQSAD....L
 1427- 1594 (236.24/160.61)	LFNP.........NGIGSTDTSSTRQNGiktflsSSERRGVWLvaPLIARLPTSVqGrvlKAAGEELEKGQH.LGSSSKKERDRQ..KQKSMSLLSQQPFLSLVLT...CL.KGQD..EQREGLLTSLQNQ.VNQILSN.........WREerYQDDIKARQMMHEALQLRLNLVGGMFDTV...QRST....QWTTDWALLL
 1611- 1758 (194.51/107.00)	LFTTvldmlgvliNGTLASDLSNASPGG......SEENKRAYM..NLVKKLKKEL.G...DKRSESIDKVRQ.LLPLPKQTCD..........VITCEPMGSLIDTkgnKI.AGFDsiDKKQGLQVSTKQK.V....SP.........W.......DLLEGQ..KNPAPLSW....AWFGTVrvdRKVI....KYEEQHHLLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.46|      12|      26|     450|     461|       3
---------------------------------------------------------------------------
  450-  461 (24.54/17.32)	EV..RWSFDKCQES
  475-  488 (18.92/11.40)	EVldRHCFDRTDSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.49|      17|      19|     128|     144|       5
---------------------------------------------------------------------------
  128-  144 (30.49/18.41)	ILAKKE...LPLAKSGVPQV
  146-  165 (26.00/14.58)	ILSKKEdvfAYLAKYSVPMV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.18|      15|      19|    1860|    1878|       6
---------------------------------------------------------------------------
 1860- 1878 (23.86/21.64)	GynlvGQPQQP.GLFLQS...QA
 1882- 1900 (19.32/ 7.39)	G....GSRLDPaGSFVPTntkQA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.17|      16|      27|     910|     926|       7
---------------------------------------------------------------------------
  910-  926 (22.97/19.10)	LLLKSSSLAGSYtTGLC
  940-  955 (29.21/19.25)	LILNPDQTAQVF.EGLC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.69|      10|     166|    1934|    1943|       8
---------------------------------------------------------------------------
 1934- 1943 (19.71/10.06)	QQQQQQRLLR
 2103- 2112 (17.98/ 8.47)	QVRQQQRLLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.68|      12|      18|     363|     376|       9
---------------------------------------------------------------------------
  363-  376 (18.37/17.04)	LSCAqhGPLVYGLS
  384-  395 (24.30/13.98)	LCCP..SALVWNYS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.29|      31|     166|     561|     621|      10
---------------------------------------------------------------------------
  574-  604 (55.38/65.68)	GSSLPVFQNVLLRFLDTQAPSLSDPNS.ECEK
  698-  729 (53.91/15.11)	GSEFPIFSPVPGESCENANPSLGRRMSvNGEK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.32|      19|     207|      21|      45|      11
---------------------------------------------------------------------------
   21-   45 (27.17/32.12)	PPDVyPQDPKQKEdeltaVNVKQGF
  231-  249 (38.16/23.51)	PPDV.EQAMRQWE.....YNEKLAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.16|      15|     125|    1096|    1115|      16
---------------------------------------------------------------------------
 1096- 1115 (21.33/28.09)	LGVLKALCCSSnhvwgFNDV
 1134- 1148 (25.84/15.62)	IAILIARQCFS.....LEDV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21091 with Med12 domain of Kingdom Metazoa
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