<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21088

Description mediator of RNA polymerase II transcription subunit 12-like protein isoform X9
SequenceMAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSARNIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDLAGNKPLAILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQATDPNLEWTQISTRYLREQLAKISDFYHLASSAGDGPVPVPPDVEQAMRQWEYNEKLAFHMFQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCARRLALLLSDGPNLLAAHSPHMMIGPNSSGIGAPSPGPPGPGMSPVQLAFSDFLSCAQHGPLVYGLSCMLQTVTLCCPSALVWNYSTNDNKSANPGSPLDLLQVAPSSLPMPGGNTAFNQQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSMETLYHKIFWANQNKDNQEAAPSDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERCGESEVLDEKESISSASLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSITASTRPRSPAGENADEHYAKDHDVKMEIFSPVPGESCENANPSLGRRMSVNGEKLLKREKPRELIFPSNYDLLRHLQYATHFPIPLDESSSHEYNQRTILLYGVGKEREEARHQLKKITKDILKILNKKSTTETGVGDEGQKARKSKQEAFPTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVIPANSNLRWDPDFMMDFIENPSARSINYSMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACLLPQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGSNNVGSLKNDDFTMRGLRRDGSADDIWTASQNSKSCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSADLNNNSSNSGMGLFNPNGIGSTDTSSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLLEGQKNPAPLSWAWFGTVRVDRKVIKYEEQHHLLLYHTHPMPKPRSYYLEPLPLPPEEEEEGPTSPISQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKSSSRVDEYPQSNMYRVPPNYSPVSSQMMHHPQSTLWGYNLVGQPQQPGLFLQSQALTPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAVMQPPSLHAITSQQQLIQMKLLQQQQQQRLLRQAQTRPFQQDFCNSAVSLLEDFDNIMGQPGDQAALFAAQARPSPQLPQYPGLQQAQTMPQGYTMYGTQMPLQQTPQQQAGSVVLSPTYNSRTYPAAHSNPALMERLRQMQQQPPSGYVQQQASPYLQPLSGSQRLNHQSLQQSPLVGGGLDAVLTSVHPNLPSVSLSQDPVRPRQPQVRQQQRLLQMQQPQQSSQPQGQTLGLQTMQPQQPLFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTPYGHPSHF
Length2153
PositionKinase
OrganismDelphinapterus leucas (Beluga whale)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Whippomorpha> Cetacea> Odontoceti> Monodontidae> Delphinapterus.
Aromaticity0.07
Grand average of hydropathy-0.408
Instability index56.13
Isoelectric point7.72
Molecular weight240385.13
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21088
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      71.97|      15|      19|    1819|    1833|       1
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 1819- 1833 (32.04/15.07)	GQPQQPGLFLQSQAL
 2006- 2019 (20.09/ 6.28)	MQQQPPSGYVQQQA.
 2104- 2115 (19.83/ 6.09)	.QPQQP.LF.PRQGL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.17|      16|      27|     864|     880|       2
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  864-  880 (22.97/18.73)	LLLKSSSLAGSYtTGLC
  894-  909 (29.21/18.87)	LILNPDQTAQVF.EGLC
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     319.47|     102|     150|    1870|    1975|       3
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  297-  345 (39.18/12.97)	.................................................................FCARRLAlLLSDGPNLLA..AHS.PHMMIgpnSSGIGAP.SPGPPG.PGM...SPVQ....................................
 1870- 1975 (172.20/102.10)	PSLH.....AITSQQQLiqMKLLQQ.....................QQQQRLLRQA.QTRPFQQDFCNSAVS.LLEDFDNIMG..QPG.DQAAL...FAAQARP.SPQLPQYPGL...QQAQ..TMPQGYTMyGTQmPL............QQTPQQQ
 1983- 2122 (108.09/53.12)	PTYNsrtypAAHSNPAL..MERLRQmqqqppsgyvqqqaspylqplSGSQRLNHQSlQQSPLVGGG...........LDAVLTsvHPNlPSVSL...SQDPVRPrQPQVRQQQRLlqmQQPQqsSQPQGQTL.GLQ.TMqpqqplfprqglQQTQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.03|      24|      28|     997|    1021|       4
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  997- 1021 (40.04/28.39)	GKIlSD..NAANRYSFVCNTLMNVCMG
 1026- 1051 (38.99/22.96)	GRI.NDiaNFSSELTACCTVLSSEWLG
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.35|      20|      27|    1111|    1136|       5
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 1115- 1136 (34.69/32.45)	ACGDADAE....PGARMTCRllLHLF
 1141- 1164 (33.66/15.39)	ACLLPQATgkpfPGIRSSCD..RHLL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     156.30|      45|     153|     490|     536|       6
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  491-  536 (73.76/50.24)	NQNKDNQEAAPSDEA......VVTLLCEWAVSCKRSGKHRAMAV..AKLLeKRQ
  615-  639 (23.69/ 8.73)	............DAY......MCTLISRGDLSITASTRPRSPA...........
  640-  688 (58.85/31.17)	GENADEHYAKDHDVKmeifspVPGESCENANP..SLG..RRMSVngEKLL.KRE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.81|      17|      27|    1479|    1495|       7
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 1479- 1495 (28.61/18.25)	QDE..QREGLLTSLQNQVN
 1507- 1525 (25.21/15.09)	QDDikARQMMHEALQLRLN
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     141.09|      50|     153|    1186|    1241|       8
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 1186- 1241 (73.96/66.37)	LGDAkiGSNNVGSLKN..DDF...TMRGLRRDGsadDIWTASQNSkSCG....KSI.SIETANLRE
 1338- 1397 (67.13/42.69)	LKDP..GSGSVAEMNNllDNIakaTIEVFQQSA...DLNNNSSNS.GMGlfnpNGIgSTDTSSTRQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.40|      18|     201|     710|     731|      10
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  710-  731 (25.83/28.46)	HFPIPlDESSSHEynqRTILLY
  914-  931 (36.57/22.75)	HVVNP.SECSSPE...RCILAY
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.32|      19|     196|      21|      45|      14
---------------------------------------------------------------------------
   21-   45 (27.17/32.45)	PPDVyPQDPKQKEdeltaVNVKQGF
  220-  238 (38.16/23.73)	PPDV.EQAMRQWE.....YNEKLAF
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.36|      13|     201|    1052|    1072|      15
---------------------------------------------------------------------------
 1052- 1069 (19.66/28.01)	VLKALCCSSnhvwgFNDV
 1090- 1102 (22.69/ 6.56)	ILIARQCFS.....LEDV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.73|      11|      31|     732|     742|      16
---------------------------------------------------------------------------
  732-  742 (20.47/10.10)	GVGKEREEARH
  764-  774 (20.27/ 9.94)	GVGDEGQKARK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     184.58|      59|     156|    1411|    1475|      18
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 1411- 1475 (92.15/58.75)	GVWLVAPLIARLPTSVQGrvlkaaGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLV.LTC
 1574- 1633 (92.43/49.26)	GVLINGTLASDLSNASPG......GSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPkQTC
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21088 with Med12 domain of Kingdom Metazoa
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