<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21087

Description mediator of RNA polymerase II transcription subunit 12-like protein isoform X4
SequenceMAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSARNIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDLAGNKPLAILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQATDPNLEWTQISTRYLREQLAKISDFYHLASSAGDGPVPVPPDVEQAMRQWEYNEKLAFHMFQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCARRLALLLSDGPNLLAAHSPHMMIGPNSSGIGAPSPGPPGPGMSPVQLAFSDFLSCAQHGPLVYGLSCMLQTVTLCCPSALVWNYSTNDNKSANPGSPLDLLQVAPSSLPMPGGNTAFNQQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSMETLYHKIFWANQNKDNQEAAPSDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERCGESEVLDEKESISSASLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSITASTRPRSPAGENADEHYAKDHDVKMEEQTIMAHMGIDSGTTNIFDEVDKSDFKTDFGSEFPIFSPVPGESCENANPSLGRRMSVNGEKLLKREKPRELIFPSNYDLLRHLQYATHFPIPLDESSSHEYNQRTILLYGVGKEREEARHQLKKITKDILKILNKKSTTETGVGDEGQKARKSKQEAFPTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVIPANSNLRWDPDFMMDFIENPSARSINYSMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACLLPQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGSNNVGSLKNDDFTMRGLRRDGSADDIWTASQNSKSCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSADLNNNSSNSGMGLFNPNGIGSTDTSSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLLEGQKNPAPLSWAWFGTVRVDRKVIKYEEQHHLLLYHTHPMPKPRSYYLEPLPLPPEEEEEGPTSPISQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKSSSRVDEYPQSNMYRVPPNYSPVSSQMMHHPQSTLWGYNLVGQPQQPGLFLQSQALTPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAVMQPPSLHAITSQQQLIQMKLLQQQQQQRLLRQAQTRPFQQDFCNSAVSLLEDFDNIMGQPGDQAALFAAQARPSPQLPQYPGLQQAQTMPQGYTMYGTQMPLQQTPQQQAGSVVLSPTYNSRTYPAAHSNPALMERLRQMQQQPPSGYVQQQASPYLQPLSGSQRLNHQSLQQSPLVGGGLDAVLTSVHPNLPSVSLSQDPVRPRQPQVRQQQRLLQMQQPQQSSQPQGQTLGLQTMQPQQPLFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTPYGHPSHF
Length2188
PositionKinase
OrganismDelphinapterus leucas (Beluga whale)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Whippomorpha> Cetacea> Odontoceti> Monodontidae> Delphinapterus.
Aromaticity0.07
Grand average of hydropathy-0.410
Instability index55.69
Isoelectric point7.08
Molecular weight244278.31
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21087
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      71.97|      15|      19|    1854|    1868|       1
---------------------------------------------------------------------------
 1854- 1868 (32.04/15.59)	GQPQQPGLFLQSQAL
 2041- 2054 (20.09/ 6.55)	MQQQPPSGYVQQQA.
 2139- 2150 (19.83/ 6.35)	.QPQQP.LF.PRQGL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     319.47|     102|     150|    1905|    2010|       2
---------------------------------------------------------------------------
  297-  345 (39.18/15.86)	.................................................................FCARRLAlLLSDGPNLLA..AHS.PHMMIgpnSSGIGAP.SPGPPG.PGM...SPVQ....................................
 1905- 2010 (172.20/123.53)	PSLH.....AITSQQQLiqMKLLQQ.....................QQQQRLLRQA.QTRPFQQDFCNSAVS.LLEDFDNIMG..QPG.DQAAL...FAAQARP.SPQLPQYPGL...QQAQ..TMPQGYTMyGTQmPL............QQTPQQQ
 2018- 2157 (108.09/64.36)	PTYNsrtypAAHSNPAL..MERLRQmqqqppsgyvqqqaspylqplSGSQRLNHQSlQQSPLVGGG...........LDAVLTsvHPNlPSVSL...SQDPVRPrQPQVRQQQRLlqmQQPQqsSQPQGQTL.GLQ.TMqpqqplfprqglQQTQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     602.02|     146|     151|    1127|    1276|       3
---------------------------------------------------------------------------
  938- 1089 (184.36/119.64)	...QVFeGLCGVVKH.VVNPS....ECSSPE..........RC.ILAYLYDLYVSCsHLRSKF.GDLF...SSACSKVKQTIYNNVIPANSNLRWDPDFMMdfIENPSARSINysmLGKILS..DNaanrysfvcntlmnV...CM.GHQDAGRINDIANFSSELTACC....TVL.SSEWLGVLK
 1127- 1276 (234.35/165.88)	IARQCF.SLEDVVQH.VALPSLLaaACGDAD..AEPG.ARMTCRLLLHLFRAPQAC.LLPQAT.GKPFPgiRSSCDRHLLAAAHNSIEVGAVFAVLKAIMM..LGDAKIGSNN...VGSLKN..DD..............F...TMRGLRRDGSADDIWTASQNSKSCG....KSI.SIETANLRE
 1285- 1432 (183.32/118.91)	ICQQ.....EWVGEHcLKEPERL...CTDKEliLDPVlSNMQAQKLLQLICYPHG...IKECTeGDNLQ..RQHIKRILQNLEQWTLRQSWLELQLMIKQC..LKDP..GSGS...VAEMNNllDN..............IakaTIEVFQQSA...DLNNNSSNS.GMGlfnpNGIgSTDTSSTRQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.12|      16|     201|    1675|    1699|       4
---------------------------------------------------------------------------
  664-  679 (28.99/ 9.78)	MG..IDSGTTNI..FDEVDK
 1676- 1695 (21.14/38.05)	MGslIDTKGNKIagFDSIDK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.32|      19|     201|      21|      45|       5
---------------------------------------------------------------------------
   21-   45 (27.17/33.71)	PPDVyPQDPKQKEdeltaVNVKQGF
  220-  238 (38.16/24.68)	PPDV.EQAMRQWE.....YNEKLAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.29|      31|     156|     539|     603|       6
---------------------------------------------------------------------------
  563-  593 (55.38/94.02)	GSSLPVFQNVLLRFLDTQAPSLSDPNS.ECEK
  687-  718 (53.91/18.95)	GSEFPIFSPVPGESCENANPSLGRRMSvNGEK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.91|      13|     111|     381|     393|       7
---------------------------------------------------------------------------
  381-  393 (25.85/17.97)	WNYSTNDNKSANP
  489-  501 (25.06/17.16)	WANQNKDNQEAAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     182.94|      59|     156|    1446|    1510|       9
---------------------------------------------------------------------------
 1446- 1510 (91.67/69.68)	GVWLVAPLIARLPTSVQGrvlkaaGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLV.LTC
 1609- 1668 (91.27/57.85)	GVLINGTLASDLSNASPG......GSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPkQTC
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21087 with Med12 domain of Kingdom Metazoa
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