<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21082

Description mediator of RNA polymerase II transcription subunit 12-like protein isoform X3
SequenceMAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSARNIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDLAGNKPLAILAKKELPLAKSGVPQVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQATDPNLEWTQISTRYLREQLAKISDFYHLASSAGDGPVPVPPDVEQAMRQWEYNEKLAFHMFQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCARRLALLLSDGPNLLAAHSPHMMIGPNSSGIGAPSPGPPGPGMSPVQLAFSDFLSCAQHGPLVYGLSCMLQTVTLCCPSALVWNYSTNDNKSANPGSPLDLLQVAPSSLPMPGGNTAFNQQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSMETLYHKIFWANQNKDNQEAAPSDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERCGESEVLDEKESISSASLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSITASTRPRSPAGENADEHYAKDHDVKMEEQTIMAHMGIDSGTTNIFDEVDKSDFKTDFGSEFPIFSPVPGESCENANPSLGRRMSVNGEKLLKREKPRELIFPSNYDLLRHLQYATHFPIPLDESSSHEYNQRTILLYGVGKEREEARHQLKKITKDILKILNKKSTTETGVGDEGQKARKSKQEAFPTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVIPANSNLRWDPDFMMDFIENPSARSINYSMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACLLPQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGSNNVGSLKNDDFTMRGLRRDGSADDIWTASQNSKSCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSADLNNNSSNSGMGLFNPNGIGSTDTSSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLLEGQKNPAPLSWAWFGTVRVDRKVIKYEEQHHLLLYHTHPMPKPRSYYLEPLPLPPEEEEEGPTSPISQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKSSSRVDYPQSNMYRVPPNYSPVSSQMMHHPQSTLWGYNLVGQPQQPGLFLQSQALTPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAVMQPPSLHAITSQQQLIQMKLLQQQQQQRLLRQAQTRPFQQDFCNSAVSLLEDFDNIMGQPGDQAALFAAQARPSPQLPQYPGLQQAQTMPQGYTMYGTQMPLQQTPQQQAGSVVLSPTYNSRTYPAAHSNPALMERLRQMQQQPPSGYVQQQASPYLQPLSGSQRLNHQSLQQSPLVGGGLDAVLTSVHPNLPSVSLSQDPVRPRQPQVRQQQRLLQMQQPQQSSQPQGQTLGLQTMQPQQPLFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTPYGHPSHF
Length2198
PositionKinase
OrganismDelphinapterus leucas (Beluga whale)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Whippomorpha> Cetacea> Odontoceti> Monodontidae> Delphinapterus.
Aromaticity0.07
Grand average of hydropathy-0.408
Instability index55.75
Isoelectric point7.17
Molecular weight245269.50
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21082
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     160.33|      24|      64|    1987|    2010|       1
---------------------------------------------------------------------------
 1910- 1933 (25.12/ 7.01)	AVMQPPSLHAIT..SQQQLIQMKLLQ
 1934- 1957 (31.81/10.74)	QQQQQRLLRQAQ..TRPFQQDFCNSA
 1987- 2010 (47.18/19.33)	QLPQYPGLQQAQ..TMPQGYTMYGTQ
 2102- 2124 (28.17/ 8.71)	NLPSV.SLSQDP..VRPRQPQVRQQQ
 2125- 2146 (28.05/ 8.64)	RLLQM...QQPQqsSQPQGQTL.GLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     115.50|      38|     204|    1830|    1886|       2
---------------------------------------------------------------------------
 1822- 1874 (54.06/52.01)	TKSSSRVDYP..QSN...MYRVppnyspvsSQMMHHPQStlwGYnlVGQPQQPglFLQ
 2027- 2069 (61.44/32.13)	SPTYNSRTYPaaHSNpalMERL........RQMQQQPPS...GY..VQQQASP..YLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.49|      17|      19|     128|     144|       3
---------------------------------------------------------------------------
  128-  144 (30.49/21.00)	ILAKKE...LPLAKSGVPQV
  146-  165 (26.00/16.65)	ILSKKEdvfAYLAKYSVPMV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.25|      32|     111|     222|     257|       5
---------------------------------------------------------------------------
   52-   88 (40.80/13.06)	TGDehGSarnIVINPSKIGAYFSSILAEKLKLNTFQD
  223-  254 (62.45/38.34)	AGD..GP...VPVPPDVEQAMRQWEYNEKLAFHMFQE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.91|      13|     111|     392|     404|       6
---------------------------------------------------------------------------
  392-  404 (25.85/17.40)	WNYSTNDNKSANP
  500-  512 (25.06/16.60)	WANQNKDNQEAAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.06|      11|      16|     678|     688|       7
---------------------------------------------------------------------------
  678-  688 (19.99/10.74)	DSGTT.NIFDEV
  696-  707 (17.07/ 8.10)	DFGSEfPIFSPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     141.14|      41|     110|    1524|    1579|       8
---------------------------------------------------------------------------
 1524- 1567 (62.85/40.39)	GQD..EQREGLLTSLQNQVNQILSNWREERYqDdiKARQMMHEALQ
 1637- 1677 (62.06/29.56)	GGS..EENKRAYMNLVKKLKKELGDKRSESI.D..KVRQLLPLPKQ
 1700- 1721 (16.23/13.70)	GFDsiDKKQGLQVSTKQKV....SPW....................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.15|      12|      19|    2157|    2168|      12
---------------------------------------------------------------------------
 2157- 2168 (24.10/12.39)	RQGLQQ..TQQQQQ
 2174- 2187 (17.05/ 6.18)	RQLQKQlsSNQPQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.46|      12|      27|     450|     461|      14
---------------------------------------------------------------------------
  450-  461 (24.54/14.75)	EV..RWSFDKCQES
  475-  488 (18.92/ 9.71)	EVldRHCFDRTDSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.17|      16|      27|     910|     926|      15
---------------------------------------------------------------------------
  910-  926 (22.97/16.85)	LLLKSSSLAGSYtTGLC
  940-  955 (29.21/16.98)	LILNPDQTAQVF.EGLC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.49|      23|      26|    1578|    1602|      16
---------------------------------------------------------------------------
 1578- 1602 (33.71/30.81)	DTVQRSTQWTTdwALLLLQIITSGT
 1604- 1626 (39.78/26.85)	DMHTNNELFTT..VLDMLGVLINGT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.04|      15|     110|     868|     886|      21
---------------------------------------------------------------------------
  868-  882 (27.11/25.94)	YHLPLAHHIQLIFDL
  889-  903 (23.92/ 9.32)	INGLIDFAIQLLNEL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21082 with Med12 domain of Kingdom Metazoa
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