<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21080

Description mediator of RNA polymerase II transcription subunit 12-like protein isoform X12
SequenceMAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSARNIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDLAGNKPLAILAKKELPLAKSGVPQVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQATDPNLEWTQISTRYLREQLAKISDFYHLASSAGDGPVPVPPDVEQAMRQWEYNEKLAFHMFQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCARRLALLLSDGPNLLAAHSPHMMIGPNSSGIGAPSPGPPGPGMSPVQLAFSDFLSCAQHGPLVYGLSCMLQTVTLCCPSALVWNYSTNDNKSANPGSPLDLLQVAPSSLPMPGGNTAFNQQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSMETLYHKIFWANQNKDNQEAAPSDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERCGESEVLDEKESISSASLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSITASTRPRSPAGENADEHYAKDHDVKMEEQTIMAHMGIDSGTTNIFDEVDKSDFKTDFGSEFPIFSPVPGESCENANPSLGRRMSVNGEKLLKREKPRELIFPSNYDLLRHLQYATHFPIPLDESSSHEYNQRTILLYGVGKEREEARHQLKKITKDILKILNKKSTTETGVGDEGQKARKSKQEAFPTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVIPANSNLRWDPDFMMDFIENPSARSINYSMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACLLPQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGSNNVGSLKNDDFTMRGLRRDGSADDIWTASQNSKSCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSADLNNNSSNSGMGLFNPNGIGSTDTSSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKTGSPGLHEAEGVPMGFA
Length1724
PositionKinase
OrganismDelphinapterus leucas (Beluga whale)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Whippomorpha> Cetacea> Odontoceti> Monodontidae> Delphinapterus.
Aromaticity0.07
Grand average of hydropathy-0.264
Instability index47.97
Isoelectric point6.20
Molecular weight191757.86
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21080
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.80|      27|     203|    1089|    1124|       1
---------------------------------------------------------------------------
 1093- 1124 (43.43/43.43)	SEWLGVLKALCCSSnhvwgFNDVLCTVDVSDL
 1131- 1157 (44.36/21.74)	ATFIAILIARQCFS.....LEDVVQHVALPSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.09|      12|      17|     122|     137|       2
---------------------------------------------------------------------------
  122-  133 (20.51/16.43)	GNKPLAILAKKE
  140-  151 (21.59/ 6.44)	GVPQVPILSKKE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.68|      12|      18|     363|     376|       3
---------------------------------------------------------------------------
  363-  376 (18.37/14.95)	LSCAqhGPLVYGLS
  384-  395 (24.30/12.30)	LCCP..SALVWNYS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.68|      16|      20|    1393|    1411|       5
---------------------------------------------------------------------------
 1393- 1411 (21.56/22.86)	AEMNNlldNIAKATIEVFQ
 1414- 1429 (28.12/19.23)	ADLNN...NSSNSGMGLFN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     113.11|      35|     169|    1329|    1363|       6
---------------------------------------------------------------------------
 1329- 1363 (63.28/47.47)	QAQKLLQLIC.YP..HGIKECTEGDNLQRQHIKRILQN
 1501- 1538 (49.83/35.50)	QKQKSMSLLSqQPflSLVLTCLKGQDEQREGLLTSLQN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.46|      12|      25|     450|     461|       7
---------------------------------------------------------------------------
  450-  461 (24.54/15.48)	EV..RWSFDKCQES
  475-  488 (18.92/10.16)	EVldRHCFDRTDSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.99|      22|      25|    1586|    1609|       8
---------------------------------------------------------------------------
 1586- 1609 (33.79/34.12)	WTTdwALLLLQIITSGTVDMHTNN
 1612- 1633 (36.20/26.25)	FTT..VLDMLGVLINGTLASDLSN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.32|      19|     202|      21|      45|       9
---------------------------------------------------------------------------
   21-   45 (27.17/35.18)	PPDVyPQDPKQKEdeltaVNVKQGF
  231-  249 (38.16/25.90)	PPDV.EQAMRQWE.....YNEKLAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.40|      16|     202|     973|    1002|      11
---------------------------------------------------------------------------
  210-  225 (29.63/10.98)	LAKISDFY....HLASSAGD
  975-  994 (25.77/36.27)	LAYLYDLYvscsHLRSKFGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.29|      31|     161|     561|     621|      17
---------------------------------------------------------------------------
  574-  604 (55.38/70.75)	GSSLPVFQNVLLRFLDTQAPSLSDPNS.ECEK
  698-  729 (53.91/16.47)	GSEFPIFSPVPGESCENANPSLGRRMSvNGEK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.78|      15|      27|    1161|    1175|      19
---------------------------------------------------------------------------
 1161- 1175 (30.61/18.35)	AC..GDADAE..PGARMTC
 1187- 1205 (21.16/10.29)	ACllPQATGKpfPGIRSSC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21080 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




NANANA









Molecular Recognition Features






MoRF SequenceStartStop




1) MAAFGL
1
6