<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21079

Description mediator of RNA polymerase II transcription subunit 12-like protein isoform X7
SequenceMAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSARNIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDLAGNKPLAILAKKELPLAKSGVPQVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQATDPNLEWTQISTRYLREQLAKISDFYHLASSAGDGPVPVPPDVEQAMRQWEYNEKLAFHMFQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCARRLALLLSDGPNLLAAHSPHMMIGPNSSGIGAPSPGPPGPGMSPVQLAFSDFLSCAQHGPLVYGLSCMLQTVTLCCPSALVWNYSTNDNKSANPGSPLDLLQVAPSSLPMPGGNTAFNQQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSMETLYHKIFWANQNKDNQEAAPSDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERCGESEVLDEKESISSASLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSITASTRPRSPAGENADEHYAKDHDVKMEIFSPVPGESCENANPSLGRRMSVNGEKLLKREKPRELIFPSNYDLLRHLQYATHFPIPLDESSSHEYNQRTILLYGVGKEREEARHQLKKITKDILKILNKKSTTETGVGDEGQKARKSKQEAFPTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVIPANSNLRWDPDFMMDFIENPSARSINYSMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACLLPQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGSNNVGSLKNDDFTMRGLRRDGSADDIWTASQNSKSCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSADLNNNSSNSGMGLFNPNGIGSTDTSSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLLEGQKNPAPLSWAWFGTVRVDRKVIKYEEQHHLLLYHTHPMPKPRSYYLEPLPLPPEEEEEGPTSPISQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKSSSRVDEYPQSNMYRVPPNYSPVSSQMMHHPQSTLWGYNLVGQPQQPGLFLQSQALTPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAVMQPPSLHAITSQQQLIQMKLLQQQQQQRLLRQAQTRPFQQDFCNSAVSLLEDFDNIMGQPGDQAALFAAQARPSPQLPQYPGLQQAQTMPQGYTMYGTQMPLQQTPQQQAGSVVLSPTYNSRTYPAAHSNPALMERLRQMQQQPPSGYVQQQASPYLQPLSGSQRLNHQSLQQSPLVGGGLDAVLTSVHPNLPSVSLSQDPVRPRQPQVRQQQRLLQMQQPQQSSQPQGQTLGLQTMQPQQPLFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTPYGHPSHF
Length2164
PositionKinase
OrganismDelphinapterus leucas (Beluga whale)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Whippomorpha> Cetacea> Odontoceti> Monodontidae> Delphinapterus.
Aromaticity0.07
Grand average of hydropathy-0.407
Instability index56.17
Isoelectric point7.72
Molecular weight241505.43
Publications









Function






Annotated function


ECO:0000256	

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats
>MDP21079
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      69.21|      19|      19|    1825|    1843|       1
---------------------------------------------------------------------------
 1825- 1839 (25.21/ 9.39)	....GYNLVGQPQQPGLFL
 2046- 2064 (20.44/ 6.10)	QSLQQSPLVGGGLDAVLTS
 2097- 2111 (23.55/ 8.24)	QPQQS....SQPQGQTLGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.49|      17|      20|     128|     144|       2
---------------------------------------------------------------------------
  128-  144 (30.49/19.46)	ILAKKE...LPLAKSGVPQV
  146-  165 (26.00/15.45)	ILSKKEdvfAYLAKYSVPMV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.11|      18|      20|    1784|    1802|       3
---------------------------------------------------------------------------
 1785- 1802 (30.78/18.87)	RKTKSSSRVDEYPQSNMY
 1807- 1824 (33.33/16.05)	NYSPVSSQMMHHPQSTLW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.17|      16|      27|     875|     891|       4
---------------------------------------------------------------------------
  875-  891 (22.97/18.90)	LLLKSSSLAGSYtTGLC
  905-  920 (29.21/19.05)	LILNPDQTAQVF.EGLC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.46|      12|      26|     450|     461|       6
---------------------------------------------------------------------------
  450-  461 (24.54/15.04)	EV..RWSFDKCQES
  475-  488 (18.92/ 9.83)	EVldRHCFDRTDSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.49|      23|      26|    1543|    1567|       7
---------------------------------------------------------------------------
 1543- 1567 (33.71/27.78)	DTVQRSTQWTTdwALLLLQIITSGT
 1569- 1591 (39.78/24.21)	DMHTNNELFTT..VLDMLGVLINGT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      70.95|      21|      26|    1936|    1956|       8
---------------------------------------------------------------------------
 1950- 1977 (20.58/ 6.01)	PS.....PQLPQYPGlqqaqtmPQGyTMYGTQM.
 2008- 2029 (21.38/ 6.58)	PAlmerlRQMQQQPP.......SG.....YVQQQ
 2125- 2145 (28.99/11.98)	GL.....QQTQQQQQ.......TAA.LVRQLQKQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.72|      17|      26|    1461|    1477|       9
---------------------------------------------------------------------------
 1461- 1477 (27.75/16.85)	KERDRQKQKSMSLLSQQ
 1488- 1504 (27.97/17.05)	KGQDEQREGLLTSLQNQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.68|      12|      19|     363|     376|      10
---------------------------------------------------------------------------
  363-  376 (18.37/16.54)	LSCAqhGPLVYGLS
  384-  395 (24.30/13.56)	LCCP..SALVWNYS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      76.80|      19|      20|    1174|    1192|      12
---------------------------------------------------------------------------
 1154- 1167 (25.25/12.30)	LLPQAT......GKPFPGIR
 1174- 1192 (30.44/16.30)	LLAAAH.NSIEVGAVFAVLK
 1196- 1211 (21.11/ 9.09)	MLGDAKiGSNNVGS....LK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.26|      28|     183|    1881|    1908|      13
---------------------------------------------------------------------------
 1881- 1908 (48.02/26.09)	PSLHAITSQQQLIQMKLLQQQQQQRLLR
 2067- 2094 (50.24/27.66)	PNLPSVSLSQDPVRPRQPQVRQQQRLLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.73|      11|      31|     743|     753|      18
---------------------------------------------------------------------------
  743-  753 (20.47/12.77)	GVGKEREEARH
  775-  785 (20.27/12.56)	GVGDEGQKARK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.67|      22|      31|     930|     954|      19
---------------------------------------------------------------------------
  930-  954 (33.94/33.32)	SECSSPERCIlaYlYDLYVSCSHLR
  963-  984 (38.74/25.56)	SACSKVKQTI..Y.NNVIPANSNLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.12|      11|     113|     222|     232|      22
---------------------------------------------------------------------------
  222-  232 (24.01/13.33)	SAGDG.PVPVPP
  337-  348 (20.11/ 9.74)	SSGIGaPSPGPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.68|      14|      19|    1653|    1667|      23
---------------------------------------------------------------------------
 1653- 1667 (19.75/16.26)	GSLIDTKgNKIAGFD
 1674- 1687 (25.93/15.87)	GLQVSTK.QKVSPWD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.56|      27|      31|    1257|    1283|      32
---------------------------------------------------------------------------
 1257- 1283 (49.24/32.78)	VLRTICQQEWVGEHCLKEPERLCTDKE
 1289- 1315 (47.31/31.16)	VLSNMQAQKLLQLICYPHGIKECTEGD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21079 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) PGDQAALFAAQARPSPQLPQYPGLQQAQTMPQGYTMYGTQMPLQQTPQQQAGSVVLSPTYNSRTYPAAHSNPALMERLRQMQQQPPSGYVQQQASPYLQPLSGSQRLNHQSLQQSPLVGGGLDAVL
2) PGLFLQSQALTPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAVMQPPSLHA
3) RSYYLEPLPLPPEEEEEGPTSPISQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKSSSRVDEYPQSNMYRVPPNYSPVSSQMMH
4) SVHPNLPSVSLSQDPVRPRQPQVRQQQRLLQMQQPQQSSQPQGQTLGLQTMQPQQPLFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTPYGHPSHF
1937
1835
1733
2064
2062
1885
1817
2164










Molecular Recognition Features






MoRF SequenceStartStop




1) MAAFG
1
5