<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21078

Description mediator of RNA polymerase II transcription subunit 12-like protein isoform X2
SequenceMAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSARNIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDLAGNKPLAILAKKELPLAKSGVPQVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQATDPNLEWTQISTRYLREQLAKISDFYHLASSAGDGPVPVPPDVEQAMRQWEYNEKLAFHMFQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCARRLALLLSDGPNLLAAHSPHMMIGPNSSGIGAPSPGPPGPGMSPVQLAFSDFLSCAQHGPLVYGLSCMLQTVTLCCPSALVWNYSTNDNKSANPGSPLDLLQVAPSSLPMPGGNTAFNQQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSMETLYHKIFWANQNKDNQEAAPSDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERCGESEVLDEKESISSASLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSITASTRPRSPAGENADEHYAKDHDVKMEEQTIMAHMGIDSGTTNIFDEVDKSDFKTDFGSEFPIFSPVPGESCENANPSLGRRMSVNGEKLLKREKPRELIFPSNYDLLRHLQYATHFPIPLDESSSHEYNQRTILLYGVGKEREEARHQLKKITKDILKILNKKSTTETGVGDEGQKARKSKQEAFPTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSACSKVKQTIYNNVIPANSNLRWDPDFMMDFIENPSARSINYSMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACLLPQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGSNNVGSLKNDDFTMRGLRRDGSADDIWTASQNSKSCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSADLNNNSSNSGMGLFNPNGIGSTDTSSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLLEGQKNPAPLSWAWFGTVRVDRKVIKYEEQHHLLLYHTHPMPKPRSYYLEPLPLPPEEEEEGPTSPISQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKSSSRVDEYPQSNMYRVPPNYSPVSSQMMHHPQSTLWGYNLVGQPQQPGLFLQSQALTPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAVMQPPSLHAITSQQQLIQMKLLQQQQQQRLLRQAQTRPFQQDFCNSAVSLLEDFDNIMGQPGDQAALFAAQARPSPQLPQYPGLQQAQTMPQGYTMYGTQMPLQQTPQQQAGSVVLSPTYNSRTYPAAHSNPALMERLRQMQQQPPSGYVQQQASPYLQPLSGSQRLNHQSLQQSPLVGGGLDAVLTSVHPNLPSVSLSQDPVRPRQPQVRQQQRLLQMQQPQQSSQPQGQTLGLQTMQPQQPLFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTPYGHPSHF
Length2198
PositionKinase
OrganismDelphinapterus leucas (Beluga whale)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Whippomorpha> Cetacea> Odontoceti> Monodontidae> Delphinapterus.
Aromaticity0.07
Grand average of hydropathy-0.409
Instability index55.66
Isoelectric point7.08
Molecular weight245311.53
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21078
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      94.95|      15|      15|    2124|    2138|       1
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 2124- 2138 (29.12/11.96)	QRL.LQMQQPQQSS....QP
 2141- 2156 (24.40/ 8.75)	QTLgLQTMQPQQPL....FP
 2158- 2176 (20.82/ 6.31)	QGL.QQTQQQQQTAalvrQL
 2177- 2191 (20.61/ 6.17)	QKQ.LSSNQPQQGV....TP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.49|      17|      18|     128|     144|       2
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  128-  144 (30.49/19.51)	ILAKKE...LPLAKSGVPQV
  146-  165 (26.00/15.43)	ILSKKEdvfAYLAKYSVPMV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.74|      15|      18|    1779|    1796|       3
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 1761- 1786 (21.20/ 9.16)	HPM...PKPRsyyleplplppEEEEEGPT
 1787- 1806 (16.54/13.61)	SPIsqePERK.........saELSDQGKT
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.22|      13|      19|    1824|    1836|       5
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 1834- 1855 (19.16/ 7.25)	NMYrvppnyspvSSQM..MHHPQS
 2005- 2019 (19.06/ 7.16)	TMY.........GTQMplQQTPQQ
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.68|      12|      18|     363|     376|       6
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  363-  376 (18.37/17.41)	LSCAqhGPLVYGLS
  384-  395 (24.30/14.28)	LCCP..SALVWNYS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.44|      15|      18|    1392|    1409|       7
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 1392- 1409 (19.95/18.55)	AEMNNlldNIAKATIEVF
 1413- 1427 (26.50/15.37)	ADLNN...NSSNSGMGLF
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     120.72|      21|      33|    1931|    1951|       8
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 1931- 1951 (35.37/15.07)	LL...QQQQQQR.....LLRQAQTRPFQQ
 1967- 1987 (34.54/14.55)	IM...GQPGDQA.....ALFAAQARPSPQ
 2044- 2069 (26.99/ 9.75)	LMerlRQMQQQP...psGYVQQQASPYLQ
 2077- 2102 (23.81/ 7.73)	LN...HQSLQQSplvggGLDAVLTSVHPN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.01|      27|     203|    1088|    1123|       9
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 1092- 1123 (42.08/47.97)	SEWLGVLKALCCSSnhvwgFNDVLCTVDVSDL
 1130- 1156 (44.93/25.08)	ATFIAILIARQCFS.....LEDVVQHVALPSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     383.85|     110|     123|     574|     690|      10
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  514-  566 (60.08/39.39)	............................................................DEAVVTLLCEWAVSCKRSGKHRAMA.......V................AKLLEKRQAE..IEAE...RCGE.SEVLDEKES
  574-  690 (187.25/168.23)	GSSLPVFQNVLLRFLDTQAPSLSDPNS.ECEKvefvnlvLLFCEFIR.......HDVFSHDAYMCTLISRGDLSITASTRPRSPAGENADEHY................AKDHDVKMEEQTIMAHMGIDSGT.TNIFDEVDK
  698-  817 (136.52/108.03)	GSEFPIFSPVPGESCENANPSLGRRMSvNGEK.......LLKREKPRelifpsnYDLLRHLQYATHF.............P.IPLDESSSHEYnqrtillygvgkereeAR.HQLKKITKDILKILNKKSTTeTGVGDEGQK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.12|      11|     115|     222|     232|      11
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  222-  232 (24.01/11.49)	SAGDG.PVPVPP
  337-  348 (20.11/ 8.38)	SSGIGaPSPGPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     286.24|     103|     182|    1239|    1366|      13
---------------------------------------------------------------------------
 1239- 1366 (133.77/144.49)	NNVGSLKNDDFTMRGLRRDGSADD...IWTasqnskscgksISIETANLREY..ARyVLRTICQQEWVGEHcL.....KEPERLcTDKELILdpvLSNmQAqkLLQLI..CYpHGIKECTEG..DNLQRQhIKRILQNleqW
 1430- 1546 (152.46/90.86)	NGIGSTDTSSTRQNGIKTFLSSSErrgVWL...........VAPLIARLPTSvqGR.VLKAAGEELEKGQH.LgssskKERDRQ.KQKSMSL...LSQ.QP..FLSLVltCL.KGQDEQREGllTSLQNQ.VNQILSN...W
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.46|      12|      26|     450|     461|      18
---------------------------------------------------------------------------
  450-  461 (24.54/14.46)	EV..RWSFDKCQES
  475-  488 (18.92/ 9.45)	EVldRHCFDRTDSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.09|      22|      27|    1160|    1183|      20
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 1160- 1183 (38.70/26.42)	AC..GDADAEP..GARMTCRllLHLFRA
 1186- 1211 (33.39/16.91)	ACllPQATGKPfpGIRSSCD..RHLLAA
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21078 with Med12 domain of Kingdom Metazoa
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