Description | mediator of RNA polymerase II transcription subunit 21 isoform X3 |
Sequence | MADRLTQLQDAVNSLADQFCNAIGVLQQCGPPASFSNIQTAINKDQPANPTEVPSFSRICPAFCSVDCTNSKRH |
Length | 74 |
Position | Middle |
Organism | Delphinapterus leucas (Beluga whale) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Whippomorpha> Cetacea> Odontoceti> Monodontidae> Delphinapterus. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.268 |
Instability index | 61.31 |
Isoelectric point | 5.48 |
Molecular weight | 7982.89 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU366036 |
GO - Cellular Component | mediator complex GO:0016592 IEA:UniProtKB-UniRule |
GO - Biological Function | |
GO - Biological Process |
Binary Interactions |
Repeats | >MDP21063 No repeats found No repeats found |
MoRF Sequence | Start | Stop |
1) DRLTQLQD 2) PASFSNIQTAINKDQPANPTEVPSFSRICPAFCSVDCTNSKRH | 3 32 | 10 74 |
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