<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21053

Description mediator of RNA polymerase II transcription subunit 12
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAITETKVKKRHVIDPFMEWTQIITKYLWEQLQKMAEYYRPGPSGSGGCGSTIGPLPHDVEVAIRQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVMSAQSTSTLPTTPAPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDPERKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKLEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSSGNTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVNNWRDDQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLRKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPALLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPAAKTEDYGMGPGRSGPYGVTVPPDLLHHTNPGSISHLSYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPPYPGVLPTTMTGVMGLEPSYKTSVYRQQQPAVPQGQRLRQQLQQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHSSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMIGTMTPLGAQGVQAGVRSASILPEQQQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQILRQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQAAPPQPQPQSQPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQPSTNIFGRY
Length2177
PositionKinase
OrganismDelphinapterus leucas (Beluga whale)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Whippomorpha> Cetacea> Odontoceti> Monodontidae> Delphinapterus.
Aromaticity0.07
Grand average of hydropathy-0.510
Instability index57.28
Isoelectric point6.70
Molecular weight243023.70
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21053
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     200.83|      17|      17|    2052|    2068|       1
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 2050- 2066 (38.39/16.44)	EQQQQ.QQQQQQQQQQQQ
 2067- 2083 (35.64/14.70)	QQQQQ.QQQQQQQYHIRQ
 2084- 2097 (23.85/ 7.18)	QQQQQiLRQQQ....QQQ
 2098- 2114 (40.38/17.71)	QQQQQ.QQQQQQQQQQQQ
 2115- 2131 (35.24/14.44)	QQQQQ.QQQQAAPPQPQP
 2132- 2149 (27.33/ 9.40)	QSQPQfQRQGLQQTQQQQ
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     527.84|     135|     345|     209|     346|       2
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  209-  346 (230.42/147.02)	GPSGSGGCGSTIGPLPHDVEV....AIRQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLL..RYSGE...FVQSAYLSRRLAYF......CTRRLAlqlDGVSSHS......SHVMSAQSTSTLPTTPAPQPPTS.STPSTP
  451-  550 (102.16/57.53)	........GFTIGRVLHTLEVldshSFERSDFSNSL......DSLCNRIFGLGPSKDGHE.ISSDDDAVVSLLCEWAVscKRSGRhraMVVAKLLEKRQAEI......EAERC.....GESEAA......DE............................
  552-  693 (195.26/117.76)	GSIASGSLSAPSAPIFQDV.......LLQF.LDTQAPMLTDPRSESERVEFFNLVLLFCELIR..HDVFSHNMYTCTL..ISRGD...LAFGAPGPRPPSPFddpaddPERKEA...EGSSSSKledpglSESMDIDPSSSVLFEDMEKPDFSlFSPTMP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     592.42|     191|     231|    1601|    1815|       3
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 1526- 1687 (125.02/84.79)	PKQLMhEALKLRLNLVGGMFDT..VQRSTQQT....TEWAVLLL......................................................................................................eiiisgtvdmqsnnelfttvldmlsvlingtlaadmsSISQGSM...EENkraymnlvKKLrkELGERQSDSLEKVRqlLPLPKqtrdVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQvsTKQKIS
 1688- 1905 (315.46/164.75)	PWDLF.EGLKPSAPLSWGWFGTVRVDRRVARG....EEQQRLLLYHTHLRPR..........PRAYYLEPLplpPEDEEPPAPALLEPEKKAPEPPKTDKPGAAPpsTEERKKKSTKgKKRSQPAAKTEDYG.MGP.GRSG.PYGV...................tvppdllhhtnpgsishlSYRQGSIglyTQN........QPL..PAGGPRVDPYRPVR..LPMQK....LPTRPPYPGVLPTTMTGVMGLEPSYKTSVYR..QQQPAV
 1906- 2042 (151.94/64.84)	PQG...QRLRQQLQQSQGMLGQSSVHQMTPSSsyglQTSQGYTPYVSHVGLQqhtgpagtmvPPSYSSQPY...QSTHSSTNPTLVDPTRHLQQRPSGYVHQQAP..TYGHGLTSTQ.RFSHQTLQQTPMIGtMTPlGAQGvQAGV...............................................................................................................................
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     211.42|      72|     233|    1143|    1219|       5
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 1143- 1219 (109.71/73.40)	LLEDLIRcAAIPSLLNAAcsEQDSEPGArlTCRILLHLFKT.PQLNPCQSDG...NKPTVG.IRSSCDRHLLAASQNRIVDG
 1379- 1455 (101.71/53.43)	LLENIAK.ATIEVFQQSA..ETGSSSGN..TASNMPSSSKTkPVLSSLERSGvwlVAPLIAkLPTSVQGHVLKAAGEELEKG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.99|      10|     232|    1290|    1303|      13
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 1092- 1101 (21.04/ 8.27)	EWLG..VLKALC
 1291- 1302 (17.95/15.88)	EWVGerCLKSLC
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     122.59|      39|     158|    1317|    1355|      15
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 1317- 1355 (71.38/37.57)	QAQRLMQLIC...YPHRLLDNEDGENPQRQ........RIKRILQNL..DQW
 1469- 1520 (51.21/25.00)	QKQKSMSLLSqqpFLSLVLTCLKGQDEQREglltslysQVHQIVNNWrdDQY
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21053 with Med12 domain of Kingdom Metazoa
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