<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21052

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMDLAYICEWEKWPKSTHCPSVPLACTWSCRNLIAFTTDLRSDDQDLTRVIHILDTEHPWDVHSICSGHSEAVTCLEWDQSGSRLLSADADGQIKCWSMADHLANSWESPVGSLVEGDPIVALSWLHNGVKLALHVEKSGASSFGEKFSRVKFSPSLTLFGGKPMEGWIAVTVSGLVTVSLLKPSGQVLTSTESLCRLRGRVALADIAFTGGGNIVVATADGSSASPVQFYKVCVSVVNEKCRIDTEILPSLFMRCTTDLNRRDRLPAITHLKFLARDMSEQVLLCASSQASSVVECWSLRKEGLPVNNIFQQLSPAVGDKQPTILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLGLALAFHDGSVHIVHRLSLQTMAIFYSSAAPRSVDEPAIKRPRTTGPAVHFKAMQLSWTSLALVGIDNHGRLSMLRISPSMGHSLDAGLALRHLLFLLEYCMVTGYDWWDILLHVQPSMVQSLVEKLHEEYTRQKAELQQVLSTRILAMKASLCKLSPCAVTRVCEYHAKLFLIAASSTLKSLLRPHVLNTPDKSPGDRLTEVCAKITDVDIDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFVLYLLASLPNQGSPLRPGHSFLRDGASLGALRELMVVIRIWGLLKPSCLPVYTATSDTQDSMSLLFRLLTKLWICCRDEGPTSEPDEALVDECCLLPSQLLIPSLDWLPVSDGLVSRLQPKQPLRLHFGKPPALPGSATSLQLDGLIRAPGQPKMDHLRRLHLGAYPTEACKACTRCGCVTMLKSPNKTTAVKQWEQRWIKNCLCGGLWWRMPLSYP
Length829
PositionTail
OrganismDelphinapterus leucas (Beluga whale)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Whippomorpha> Cetacea> Odontoceti> Monodontidae> Delphinapterus.
Aromaticity0.07
Grand average of hydropathy0.037
Instability index48.68
Isoelectric point7.88
Molecular weight91604.37
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl

GO - Biological Function
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription coactivator activity	GO:0003713	IEA:Ensembl

GO - Biological Process
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21052
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.91|      24|      33|     720|     751|       1
---------------------------------------------------------------------------
  720-  744 (42.50/34.35)	LPVsDGLV.SRLQPKQP..LRLHFGKPP
  753-  779 (37.42/13.71)	LQL.DGLIrAPGQPKMDhlRRLHLGAYP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     159.51|      45|     183|     419|     463|       2
---------------------------------------------------------------------------
  122-  169 (28.96/12.53)	.......LSWlhngVK....LALhvekSGASSFGeKFSRVKFSPSLtlfgGKPM..E.GWI.A.....
  419-  463 (83.20/50.14)	FKAMQ..LSW....TS....LAL....VGIDNHG.RLSMLRISPSM....GHSL..D.AGL.ALRHLL
  599-  647 (47.35/25.29)	LQALQqlLQW....VGdfvlYLL....ASLPNQG...SPLR..P......GHSFlrDgASLgALRELM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.17|      32|     184|      83|     119|       3
---------------------------------------------------------------------------
   84-  118 (56.80/42.89)	LL..SADADGQIKCWSMADH...LANSWE..SP.VGslvEGDP
  283-  322 (39.36/14.71)	LLcaSSQASSVVECWSLRKEglpVNNIFQqlSPaVG...DKQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.37|      12|      36|     525|     539|       6
---------------------------------------------------------------------------
  525-  539 (18.64/17.46)	SPC.AVTRVCeyhAKL
  563-  575 (18.74/ 8.19)	SPGdRLTEVC...AKI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.13|      14|      31|     672|     685|       7
---------------------------------------------------------------------------
  672-  685 (25.53/12.48)	DSMSLLFR..LLTKL.W
  703-  719 (19.60/ 7.97)	DECCLLPSqlLIPSLdW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.63|      12|     343|     469|     481|       8
---------------------------------------------------------------------------
  469-  481 (22.72/13.27)	CMVTGYdWWDILL
  815-  826 (28.92/13.13)	CLCGGL.WWRMPL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21052 with Med16 domain of Kingdom Metazoa
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