<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21050

Description mediator of RNA polymerase II transcription subunit 24 isoform X3
SequenceMKVVNLKQAILQAWKERWSDYQWAINMKKFFPKGATWDILNLAEALLEQAMIGPSPNPLILSYLKYAISSQMVSYSSVLTAISKFDDFSRDLCVQALLDIMDMFCDRLSCHGKAEECIGLCRALLSALHWLLRCTAASAERLREGLEAGTPAAGEKQLAMCLQRLEKTLSSTKNRALLHIAKLEEASSWTAIEHCLLKLGEILANLSSPQLRSQAEQCGTLIRSIPTMLSVHSERLHKTGFPTVHAVVLLEGTVNLTGETQPLVEQLVMVQRMQHIPTPLFVLEIWKACFVGLIESPEGTGELKWTAFTFLKIPQVLVKLKKYSHGDKDFTEDVSSAFEFLLKLTPLLDKADQRCNCDCTNFLLQECSKQGLLSEASTNNLMAKRKADREHAPQLKSDENANIQPNPGLILRAEPTVTNILKTMDADHSKSPEGLLGVLGHMLSGKSLDLLLAAAAATGKLKSFARKFINLNEFTTHRSEESSWGSAFSSFTAKAASVRALLFDISFLMLCHVAQTYGSEVILSESNTGGEVFFFETWMQTCMPEEGKILNPDHPCFRPDSTKVESLVALLNNSSEIKLVQMKWHEACLNISAAILEILNAWENGVLAFESIQKITDNIKGKVCSLAVCAVAWLVAHVRMLGLDEREKSLQMIRQLAGPLYSENTLQFYNERVVIMSSILEHMCADVLQQTATQIKFPSTGMDTMPYWNLLPPKRPIKEVLTDIFAKVLEKGWVDSRSIHIFDTLLHMGGVYWFCNNLIKELLKETRKEHTLRAVELLYSIFCLDMQQVTLVLLGHILPGLLTDSSKWQSLMDPPGTALAKLAVWCALSSYSSHKGQASSRQKKRQREDIEDYISLFPLDDMQPSKLMRLLSSNEEDANILSSPTDRSMSSNLSASQLHTVNMRDPLNRVLANLFLLISSILGSRTAGPHTQFAQWFMEGCVDCLEQGGRGSILQFMPFTTVSELVKVSAMSSPKVVLAITDLSLPLGRQVAAKAIAAL
Length999
PositionTail
OrganismDelphinapterus leucas (Beluga whale)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Whippomorpha> Cetacea> Odontoceti> Monodontidae> Delphinapterus.
Aromaticity0.07
Grand average of hydropathy0.013
Instability index46.76
Isoelectric point6.51
Molecular weight111202.93
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21050
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     156.81|      47|     182|     714|     767|       1
---------------------------------------------------------------------------
  714-  767 (72.75/67.92)	KRPIKEVLTDIFakVLEKGWVDSRSIHIfdtllHMGGVYWFCNNLIKELLKETR
  904-  950 (84.06/58.68)	RDPLNRVLANLF..LLISSILGSRTAGP.....HTQFAQWFMEGCVDCLEQGGR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.63|      19|     185|     209|     227|       2
---------------------------------------------------------------------------
  209-  227 (35.13/28.41)	PQLRSQAEQC.....GTLIRSIPT
  393-  416 (27.50/20.34)	PQLKSDENANiqpnpGLILRAEPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.92|      19|     184|     290|     308|       5
---------------------------------------------------------------------------
  290-  308 (35.61/25.33)	FVGLIE.SPEGTGELKW.TAF
  468-  488 (24.30/14.73)	FINLNEfTTHRSEESSWgSAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     175.47|      51|     116|     660|     711|       6
---------------------------------------------------------------------------
  660-  711 (86.16/64.03)	LYSENTLQFYNERVVIMSSILEHMCADVlQQTATQIKFPSTGMDTMPYWNLL
  778-  828 (89.31/61.85)	LYSIFCLDMQQVTLVLLGHILPGLLTDS.SKWQSLMDPPGTALAKLAVWCAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     139.78|      46|     247|      78|     126|       7
---------------------------------------------------------------------------
   78-  126 (74.38/54.07)	VLTAISKFD....DFSRD........LCVQALLDIMDMFCDrLSCHG.KAEECIGlcRALLS
  316-  374 (65.39/37.32)	VLVKLKKYShgdkDFTEDvssafeflLKLTPLLDKADQRCN.CDCTNfLLQECSK..QGLLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.94|      19|     144|     496|     514|       9
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  496-  514 (34.06/24.35)	ASVRALLFD...ISFLMLCHVA
  636-  657 (26.89/17.55)	AHVRMLGLDereKSLQMIRQLA
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21050 with Med24 domain of Kingdom Metazoa
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