<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21043
Description |
mediator of RNA polymerase II transcription subunit 14 isoform X1 |
Sequence | MAPVQLENQLVPPGGGGGGSSGPASAPAPPPPGAAVAAAAAAAASPGYRLSTLIEFLLHRAYSELMVLTDLLPRKSDVERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDVPWRLLKLEILVEDKETGDGRALVHSMQINFIHQLVQSRLFADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIKIDENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQKLQELKAILRGFNANENSSIETALPALVVPILEPCGNSECLHIFVDLHSGMFQLMLYGLDQATLDDMEKSVNDDMKRIIPWIQQLKFWLGQQRCKQSIKHLPTISSETLQLSNYSTHPIGNLSKNKLFIKLTRLPQYYIVVEMLEVPNKPTQLSYKYYFMSVNAADREDSPVVALLLQQFKENIQELVYRTKNGKQPRSSTKRKLSDDLCPVEPKKTKRSGEMCAFNKVLAHFVAMCDTNMPFVGLRLELSNLEIPHQGVQMEGDGFSHAIRLLKIPPCKGVNEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWNSIARLYECVLEFARSLPDIPTHLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSIHQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPPQQQPFPKQPGSSGAYPLTSPPASYHSTVSQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPATRMPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTSVPPQEPVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQGECTIFAAVRDLMANLTLPPGGRP |
Length | 1453 |
Position | Tail |
Organism | Delphinapterus leucas (Beluga whale) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Laurasiatheria> Artiodactyla> Whippomorpha> Cetacea> Odontoceti>
Monodontidae> Delphinapterus.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.187 |
Instability index | 53.10 |
Isoelectric point | 8.97 |
Molecular weight | 160584.64 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU365082
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GO - Cellular Component | mediator complex GO:0016592 IEA:UniProtKB-UniRule
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:UniProtKB-UniRule
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP21043
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
4| 271.48| 62| 64| 1001| 1062| 1
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1001- 1025 (30.62/ 7.71) .............................................PPPQQQPFPKQPGSSGAYPL.TSPPA
1026- 1093 (101.23/42.94) SYHSTVSQSPSMMHTQSPGNLHAASSPSGALRAP..SPA.sfvptPPPSSHGISIGPGASFASPHgTLDPS
1094- 1160 (97.04/40.85) SPYTMV..SPSGRAGNWPGS.PQVSGPSPATRMPgmSPAnpslhsPVPDASHSPRAGTSSQTMPT.NMPPP
1164- 1198 (42.58/13.67) PQRSWAASIPTIL.THSALNILLLPSPTPGL.VP..GLA................................
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 94.64| 30| 31| 245| 274| 2
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245- 274 (48.89/36.77) RLLKLEILVEDKETGDGRALVH....SMQINFIH
275- 308 (45.75/33.88) QLVQSRLFADEKPLQDMYNCLHsfclSLQLEVLH
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 46.88| 12| 32| 1339| 1350| 3
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1339- 1350 (23.85/11.07) LTIPPSAPPIAP
1368- 1379 (23.03/10.41) LTQKTSVPPQEP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 87.55| 28| 32| 508| 539| 4
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508- 539 (41.94/36.26) IKHLPT..ISSETLQLSNYSTHpignLSKNKLFI
541- 570 (45.60/28.07) LTRLPQyyIVVEMLEVPNKPTQ....LSYKYYFM
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 37.33| 10| 24| 1401| 1410| 6
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1401- 1410 (17.56/ 9.42) PRQQNSSVAA
1427- 1436 (19.77/11.52) PRQGECTIFA
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 104.27| 32| 32| 65| 96| 8
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65- 96 (51.36/33.06) LMVLTDLLPRKSDVERKIEIVQFASRTRQLFV
98- 129 (52.92/34.27) LLALVKWANNAGKVEKCAMISSFLDQQAILFV
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 45.49| 14| 27| 167| 180| 9
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167- 180 (26.30/12.93) RLPTCIRDKII....PPD
193- 210 (19.19/ 7.46) QLNQILRHRLVttdlPPQ
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 153.50| 50| 503| 364| 456| 10
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396- 447 (75.67/100.83) IEKLLiDSVHARAH.QKLQElKAILRGFNANENSSIETALPALVVPI.LEPCGN
1206- 1257 (77.83/27.45) LERFL.GSVIMRRHlQRIIQ.QETLQLINSNEPGVIMFKTDALKCRVaLSPKTN
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