Description | Mediator of RNA polymerase II transcription subunit 1 |
Sequence | MSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAVMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYASPSDLLDDKTTSPIILHENNVPRSLGMNASVTIEGTSAMYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYVPLYELITQFELSKDPDPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEMCSGSNKAKKKKSSRLPPDKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQSSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDCPPIGTPVRDSSSSGHSQSALFDPDVFQANNNENPYTDPADLIADAAGSPSSDSPTNHFFPDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFTSQALNTLGVPMLGGDNGETKFKGNSQADTVDFSIIAVAGKALGPTDLMEHHSGSQSPLLTTGDLGKEKTQKRVKEGNGTSNSSLSGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSGSKSHYSHSSSSSASNSGKMKSSKSEGSSSSKLSSSIYSSQGSSGSSQSKNSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPGGSDKLASPMKPVPVTPPSSKAKSPISSGSGGSHMSGTSSSTGIKSSSGLGSSGSLSQKTPPSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPMDGQVGVSTNSSSHPVSSKHNMSGGEFQGKREKSDKDKSKVSTLGGSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDKDRDRDRDKDRDKKKSHSIKPESWSKSPISSDQSLSMTSNTILSTDRPSRLSPDFMIGEEDDDLMDVALIGN |
Length | 1530 |
Position | Middle |
Organism | Delphinapterus leucas (Beluga whale) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Whippomorpha> Cetacea> Odontoceti> Monodontidae> Delphinapterus. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.667 |
Instability index | 53.76 |
Isoelectric point | 8.79 |
Molecular weight | 162536.40 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364059 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP21042 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 7| 290.95| 45| 50| 1281| 1325| 3 --------------------------------------------------------------------------- 565- 611 (41.61/ 9.31) G.GS.TI.G.....S....SP....TP...P.........H......HTPPPvSSM.A.GNTKnhpmlmnllKD..NPAQDFST...L 989- 1043 (38.72/ 8.05) G.GSKSP.G.....S....SGRSQ.TP...PgVA....TPPipkitiQIPKG.TVMvG.KPSS.........HSqyTSSGSVSS...S 1162- 1198 (45.75/11.10) P.VTPPS.S.....K.........aKS...P.IS....SG.........SGG.SHM.S.GTSS.........ST..GIKSS.SG...L 1267- 1317 (58.09/16.45) GpGGEDPmD.....GqvgvSTNSS.SH...P.VS....SKH......NMSGG.EFQ.G.KREK.........SD..KDKSKVST...L 1318- 1359 (35.13/ 6.50) G.GSVDS.S.....KktseSKNVG.ST...G.VAkiiiSKH......D..GG....................SP..SIKAKV.T...L 1360- 1410 (34.67/ 6.30) Q.KPGES.SgeglrPqmasSKNYG.S....P.L...............ISGS.TPK.H.ERGS.........PS..HSKSPAYTpqnL 1411- 1459 (36.97/ 7.30) D.SESES.G.....S....SIAEK.SYqnsP.SS....DDG......IRPLP.EYS.TeKHKK.........HK..KEKKKVKD...K --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 4| 127.98| 25| 49| 706| 730| 5 --------------------------------------------------------------------------- 651- 677 (22.94/ 6.47) PKHQTEDDFQRelfsM....DVDS....QNPifDV 706- 730 (46.47/22.23) PVPHPQSSIQR....MVRLSSSDS....IGP..DV 757- 776 (30.89/11.79) PVRDSSSSGH.........SQSAL....FDP..DV 785- 812 (27.68/ 9.64) PYTDPADLIAD....AAGSPSSDSptnhFFP..D. --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 101.70| 31| 49| 103| 150| 6 --------------------------------------------------------------------------- 103- 134 (49.83/49.52) KHLKGLVNlYNLP..GDNKLKTKMYLALQSLEQD 153- 185 (51.88/19.88) KILHGSVG.YLTPrsGGHLMNLKYYASPSDLLDD --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 47.56| 13| 26| 278| 290| 7 --------------------------------------------------------------------------- 278- 290 (24.80/12.17) IPLFETQPTYVPL 306- 318 (22.76/10.57) IPLNHNMRFYAAL --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 63.56| 23| 50| 860| 892| 8 --------------------------------------------------------------------------- 860- 883 (36.76/17.76) PML.GGDNGETKFK.....GNSQADTvDFS 907- 935 (26.80/15.25) PLLtTGDLGKEKTQkrvkeGNGTSNS.SLS --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 4| 168.21| 33| 50| 1075| 1107| 9 --------------------------------------------------------------------------- 615- 644 (38.38/11.26) SPL......ERQNS.....SSGSPRMEMCS..GSnkakkKKSS 1075- 1104 (49.68/17.17) ...KLSSSIYSSQG.....SSGSSQSKNSSQSGG.....KPGS 1105- 1129 (31.79/ 7.82) SPI...........tkhglSSGSSSTKMKPQ..G.....KPSS 1213- 1242 (48.36/16.48) NSCTASSSSFS........SSGSSMSSSQNQHGS.....SKGK --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 136.12| 44| 340| 52| 101| 10 --------------------------------------------------------------------------- 52- 101 (67.78/58.60) CYITSDMFYVEVQlDPAGQ..LC...DVKVAHHgenpVSCpELVQQLREK..NFDEF 394- 444 (68.34/40.17) CPLSESRFSVSFQ.HPVNDslVCvvmDVQDSTH....VSC.KLYKGLSDAliCTDDF --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 61.41| 17| 69| 253| 273| 12 --------------------------------------------------------------------------- 253- 273 (28.91/25.53) CFFLKFPQPIPVSRAfvqkLQ 324- 340 (32.50/18.04) CYFLNKDAPLPDGRS....LQ --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 42.11| 13| 115| 359| 387| 15 --------------------------------------------------------------------------- 341- 353 (23.51/32.08) GTLVSKITFQH..PG 373- 387 (18.60/ 7.75) GSCVKRTILKEdsPG --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) FGEEYF 2) IKAKVTLQ 3) IRPLPEYSTEKHKKHKKEKKKVKDK 4) KKPSLTAVIDKLKHGV 5) PKITIQIPKGT 6) RLSPDFMIGEEDDDLMDV 7) VAKIIISKH | 829 1353 1435 1248 1012 1508 1338 | 834 1360 1459 1263 1022 1525 1346 |
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