<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21042

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAVMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYASPSDLLDDKTTSPIILHENNVPRSLGMNASVTIEGTSAMYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYVPLYELITQFELSKDPDPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEMCSGSNKAKKKKSSRLPPDKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQSSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDCPPIGTPVRDSSSSGHSQSALFDPDVFQANNNENPYTDPADLIADAAGSPSSDSPTNHFFPDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFTSQALNTLGVPMLGGDNGETKFKGNSQADTVDFSIIAVAGKALGPTDLMEHHSGSQSPLLTTGDLGKEKTQKRVKEGNGTSNSSLSGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSGSKSHYSHSSSSSASNSGKMKSSKSEGSSSSKLSSSIYSSQGSSGSSQSKNSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPGGSDKLASPMKPVPVTPPSSKAKSPISSGSGGSHMSGTSSSTGIKSSSGLGSSGSLSQKTPPSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPMDGQVGVSTNSSSHPVSSKHNMSGGEFQGKREKSDKDKSKVSTLGGSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDKDRDRDRDKDRDKKKSHSIKPESWSKSPISSDQSLSMTSNTILSTDRPSRLSPDFMIGEEDDDLMDVALIGN
Length1530
PositionMiddle
OrganismDelphinapterus leucas (Beluga whale)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Whippomorpha> Cetacea> Odontoceti> Monodontidae> Delphinapterus.
Aromaticity0.05
Grand average of hydropathy-0.667
Instability index53.76
Isoelectric point8.79
Molecular weight162536.40
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21042
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     290.95|      45|      50|    1281|    1325|       3
---------------------------------------------------------------------------
  565-  611 (41.61/ 9.31)	G.GS.TI.G.....S....SP....TP...P.........H......HTPPPvSSM.A.GNTKnhpmlmnllKD..NPAQDFST...L
  989- 1043 (38.72/ 8.05)	G.GSKSP.G.....S....SGRSQ.TP...PgVA....TPPipkitiQIPKG.TVMvG.KPSS.........HSqyTSSGSVSS...S
 1162- 1198 (45.75/11.10)	P.VTPPS.S.....K.........aKS...P.IS....SG.........SGG.SHM.S.GTSS.........ST..GIKSS.SG...L
 1267- 1317 (58.09/16.45)	GpGGEDPmD.....GqvgvSTNSS.SH...P.VS....SKH......NMSGG.EFQ.G.KREK.........SD..KDKSKVST...L
 1318- 1359 (35.13/ 6.50)	G.GSVDS.S.....KktseSKNVG.ST...G.VAkiiiSKH......D..GG....................SP..SIKAKV.T...L
 1360- 1410 (34.67/ 6.30)	Q.KPGES.SgeglrPqmasSKNYG.S....P.L...............ISGS.TPK.H.ERGS.........PS..HSKSPAYTpqnL
 1411- 1459 (36.97/ 7.30)	D.SESES.G.....S....SIAEK.SYqnsP.SS....DDG......IRPLP.EYS.TeKHKK.........HK..KEKKKVKD...K
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     127.98|      25|      49|     706|     730|       5
---------------------------------------------------------------------------
  651-  677 (22.94/ 6.47)	PKHQTEDDFQRelfsM....DVDS....QNPifDV
  706-  730 (46.47/22.23)	PVPHPQSSIQR....MVRLSSSDS....IGP..DV
  757-  776 (30.89/11.79)	PVRDSSSSGH.........SQSAL....FDP..DV
  785-  812 (27.68/ 9.64)	PYTDPADLIAD....AAGSPSSDSptnhFFP..D.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.70|      31|      49|     103|     150|       6
---------------------------------------------------------------------------
  103-  134 (49.83/49.52)	KHLKGLVNlYNLP..GDNKLKTKMYLALQSLEQD
  153-  185 (51.88/19.88)	KILHGSVG.YLTPrsGGHLMNLKYYASPSDLLDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.56|      13|      26|     278|     290|       7
---------------------------------------------------------------------------
  278-  290 (24.80/12.17)	IPLFETQPTYVPL
  306-  318 (22.76/10.57)	IPLNHNMRFYAAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.56|      23|      50|     860|     892|       8
---------------------------------------------------------------------------
  860-  883 (36.76/17.76)	PML.GGDNGETKFK.....GNSQADTvDFS
  907-  935 (26.80/15.25)	PLLtTGDLGKEKTQkrvkeGNGTSNS.SLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     168.21|      33|      50|    1075|    1107|       9
---------------------------------------------------------------------------
  615-  644 (38.38/11.26)	SPL......ERQNS.....SSGSPRMEMCS..GSnkakkKKSS
 1075- 1104 (49.68/17.17)	...KLSSSIYSSQG.....SSGSSQSKNSSQSGG.....KPGS
 1105- 1129 (31.79/ 7.82)	SPI...........tkhglSSGSSSTKMKPQ..G.....KPSS
 1213- 1242 (48.36/16.48)	NSCTASSSSFS........SSGSSMSSSQNQHGS.....SKGK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     136.12|      44|     340|      52|     101|      10
---------------------------------------------------------------------------
   52-  101 (67.78/58.60)	CYITSDMFYVEVQlDPAGQ..LC...DVKVAHHgenpVSCpELVQQLREK..NFDEF
  394-  444 (68.34/40.17)	CPLSESRFSVSFQ.HPVNDslVCvvmDVQDSTH....VSC.KLYKGLSDAliCTDDF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.41|      17|      69|     253|     273|      12
---------------------------------------------------------------------------
  253-  273 (28.91/25.53)	CFFLKFPQPIPVSRAfvqkLQ
  324-  340 (32.50/18.04)	CYFLNKDAPLPDGRS....LQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.11|      13|     115|     359|     387|      15
---------------------------------------------------------------------------
  341-  353 (23.51/32.08)	GTLVSKITFQH..PG
  373-  387 (18.60/ 7.75)	GSCVKRTILKEdsPG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21042 with Med1 domain of Kingdom Metazoa
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