<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21037

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAVMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYASPSDLLDDKTTSPIILHENNVPRSLGMNASVTIEGTSAMYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYVPLYELITQFELSKDPDPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEMCSGSNKAKKKKSSRLPPDKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQSSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDCPPIGTPVRDSSSSGHSQSALFDPDVFQANNNENPYTDPADLIADAAGSPSSDSPTNHFFPDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFTSQALNTLGVPMLGGDNGETKFKGNSQADTVDFSIIAVAGKALGPTDLMEHHSGSQSPLLTTGDLGKEKTQKRVKEGNGTSNSSLSGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSGSKSHYSHSSSSSASNSGKMKSSKSEGSSSSKLSSSIYSSQGSSGSSQSKNSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPGGSDKLASPMKPVPVTPPSSKAKSPISSGSGGSHMSGTSSSTGIKSSSGLGSSGSLSQKTPPSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPMDGQVGVSTNSSSHPVSSKHNMSGGEFQGKREKSDKDKSKVSTLGGSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDKDRDRDRDKDRDKKKSHSIKPESWSKSPISSDQSLSMTSNTILSTDRPSRLSPDFMIGEEDDDLMDVALIGN
Length1579
PositionMiddle
OrganismDelphinapterus leucas (Beluga whale)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Whippomorpha> Cetacea> Odontoceti> Monodontidae> Delphinapterus.
Aromaticity0.04
Grand average of hydropathy-0.673
Instability index53.84
Isoelectric point8.88
Molecular weight168320.06
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364059

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21037
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     221.15|      45|      50|    1330|    1374|       3
---------------------------------------------------------------------------
  614-  660 (41.61/ 8.29)	G.GS.TI.GS....SP....TP...P.....H......HTPPPvSSM.A.GNTKnhpmlmnllKD..NPAQDFSTL
 1038- 1092 (38.72/ 7.16)	G.GSKSP.GS....SGRSQ.TP...PgVATPPipkitiQIPKG.TVMvG.KPSS.........HSqyTSSGSVSSS
 1211- 1247 (45.75/ 9.89)	P.VTPPS.SK.........aKS...P.ISSG.........SGG.SHM.S.GTSS.........ST..GIKSS.SGL
 1316- 1366 (58.09/14.68)	GpGGEDPmDGqvgvSTNSS.SH...P.VSSKH......NMSGG.EFQ.G.KREK.........SD..KDKSKVSTL
 1460- 1508 (36.97/ 6.49)	D.SESES.GS....SIAEK.SYqnsP.SSDDG......IRPLP.EYS.TeKHKK.........HK..KEKKKVKDK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     146.19|      41|      50|     324|     373|       5
---------------------------------------------------------------------------
  272-  321 (49.01/17.79)	......PLiMGSHPVdnkWTPSFSSITSansvdlpacFFL.KFPQPIPVSRA....FVQKL
  322-  367 (69.04/33.04)	QnctgiPL.FETQPT...YVPLYELITQ.........FELSKDPDPIPLNHNMR..FYAAL
  371-  396 (28.14/18.11)	Q..................................hcYFLNKDA.PLPDGRSLQgtLVSKI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     314.86|      55|     151|    1248|    1302|       6
---------------------------------------------------------------------------
 1122- 1157 (49.34/12.32)	................SSKLSSSIYSSQG.SS..GSSQSKNSSQSGGKP..GSSP.IT
 1160- 1209 (71.18/21.48)	GlSSGSSSTKMKPQGKPSSLMNPSLSKPN.ISP.SHSRPPGGSDKLASPMKP......
 1248- 1302 (95.60/31.72)	G.SSGSLSQKTPPSSNSCTASSSSFSSSG.SSM.SSSQNQHGSSKGKSPSRNKKPSLT
 1367- 1412 (49.08/12.21)	G.GSVDSSKKTSESKN........VGSTGvAKI.IISKHDGGSPSIKAKVTLQKPG..
 1417- 1455 (49.67/12.46)	........EGLRPQ....MASSKNY...G.SPLiSGSTPKH..ERG.SPSHSKSPAYT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     216.23|      58|     340|     556|     613|       7
---------------------------------------------------------------------------
  556-  589 (46.46/20.10)	.......................................................PM..................SGTTTPTNTFP...GGPITTLFNM.SMSIKDRHESV
  590-  694 (68.53/34.19)	GHGEDFS.KV.SQNPILTSLLQITGNggstigssptpphhtpppvssmagntknhPMlmnllkdnpaqdfstlygSSPLERQNSSS...GSPRMEMCSG.SNKAKKKKSSR
  708-  775 (62.30/30.21)	FQRELFSmDVdSQNPIFD..VNMTAD.............................TL.........dtphitpapSQCSTPPTTYPqpvPHPQSSIQRMvRLSSSD...SI
  776-  822 (38.93/15.28)	..GPDVT.......DILSDIAEEASK.....................lpstsddcPP..................IGTPVRDSSSS...GHSQSALFD.............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     123.79|      38|      49|     146|     183|       8
---------------------------------------------------------------------------
  146-  164 (21.42/ 7.31)	..................................NFD.EFSKHLKGLVNLYNLP
  165-  213 (53.46/29.25)	GDNKLKTKMYLALQSLEQD...lskmavmywkatNAG.PLDKILHGSVG.YLTP
  216-  269 (48.91/26.13)	GGHLMNLKYYASPSDLLDDkttspiilhennvprSLGmNASVTIEGTSAMYKLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.12|      20|      23|     938|     957|       9
---------------------------------------------------------------------------
  938-  957 (36.37/17.57)	GKALGPTDLMEHHSGSQSPL
  964-  983 (30.75/13.58)	GKEKTQKRVKEGNGTSNSSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.82|      14|      22|     451|     464|      10
---------------------------------------------------------------------------
  451-  464 (25.65/14.20)	SVSFQHPVNDSLVC
  476-  489 (25.17/13.80)	SCKLYKGLSDALIC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.38|      18|     699|     122|     139|      12
---------------------------------------------------------------------------
  122-  139 (34.40/17.85)	DVKVAHHGENPVSCP.ELV
  824-  842 (29.98/14.69)	DVFQANNNENPYTDPaDLI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21037 with Med1 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FSIIAVAGKALGPTDLMEHHSGSQSPLLTTGDLGKEKTQKRVKEGNGTSNSSLSGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSGSKSHYSHSSSSSASNSGKMKSSKSEGSSSSKLSSSIYSSQGSSGSSQSKNSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPGGSDKLASPMKPVPVTPPSSKAKSPISSGSGGSHMSGTSSSTGIKSSSGLGSSGSLSQKTPPSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPMDGQVGVSTNSSSHPVSSKHNMSGGEFQGKREKSDKDKSKVSTLGGSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDKDRDRDRDKDRDKKKSHSIKPESWSKSPISSDQSLSMTSNTILSTDRPSRLSPDFMIGEEDDDLMDVALIGN
2) KNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGP
3) LFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEMCSGSNKAKKKKSSRLPPDKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQSSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDCPPIGTPVRDSSSSGHSQSALFDPDVFQANNNENPYTDPADLIADAAGSPSSDSPTNHFFPDGVDFN
4) LLNSQSQSGFGEEYFDESSQSGDNDDFKGFTSQALNTLGVPMLGGDNGETKFKGNSQAD
931
538
575
869
1579
571
866
927










Molecular Recognition Features






MoRF SequenceStartStop




1) FGEEYF
2) IKAKVTLQK
3) IPKITIQIPKGT
4) IRPLPEYSTEKHKKHKKEKKKVKDKDR
5) KKPSLTAVIDKLKHGVV
6) RLSPDFMIGEEDDDLMDV
7) VAKIIISKH
878
1402
1060
1484
1297
1557
1387
883
1410
1071
1510
1313
1574
1395