<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21037

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAVMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYASPSDLLDDKTTSPIILHENNVPRSLGMNASVTIEGTSAMYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYVPLYELITQFELSKDPDPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEMCSGSNKAKKKKSSRLPPDKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQSSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDCPPIGTPVRDSSSSGHSQSALFDPDVFQANNNENPYTDPADLIADAAGSPSSDSPTNHFFPDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFTSQALNTLGVPMLGGDNGETKFKGNSQADTVDFSIIAVAGKALGPTDLMEHHSGSQSPLLTTGDLGKEKTQKRVKEGNGTSNSSLSGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSGSKSHYSHSSSSSASNSGKMKSSKSEGSSSSKLSSSIYSSQGSSGSSQSKNSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPGGSDKLASPMKPVPVTPPSSKAKSPISSGSGGSHMSGTSSSTGIKSSSGLGSSGSLSQKTPPSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPMDGQVGVSTNSSSHPVSSKHNMSGGEFQGKREKSDKDKSKVSTLGGSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDKDRDRDRDKDRDKKKSHSIKPESWSKSPISSDQSLSMTSNTILSTDRPSRLSPDFMIGEEDDDLMDVALIGN
Length1579
PositionMiddle
OrganismDelphinapterus leucas (Beluga whale)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Whippomorpha> Cetacea> Odontoceti> Monodontidae> Delphinapterus.
Aromaticity0.04
Grand average of hydropathy-0.673
Instability index53.84
Isoelectric point8.88
Molecular weight168320.06
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21037
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     221.15|      45|      50|    1330|    1374|       3
---------------------------------------------------------------------------
  614-  660 (41.61/ 8.29)	G.GS.TI.GS....SP....TP...P.....H......HTPPPvSSM.A.GNTKnhpmlmnllKD..NPAQDFSTL
 1038- 1092 (38.72/ 7.16)	G.GSKSP.GS....SGRSQ.TP...PgVATPPipkitiQIPKG.TVMvG.KPSS.........HSqyTSSGSVSSS
 1211- 1247 (45.75/ 9.89)	P.VTPPS.SK.........aKS...P.ISSG.........SGG.SHM.S.GTSS.........ST..GIKSS.SGL
 1316- 1366 (58.09/14.68)	GpGGEDPmDGqvgvSTNSS.SH...P.VSSKH......NMSGG.EFQ.G.KREK.........SD..KDKSKVSTL
 1460- 1508 (36.97/ 6.49)	D.SESES.GS....SIAEK.SYqnsP.SSDDG......IRPLP.EYS.TeKHKK.........HK..KEKKKVKDK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     146.19|      41|      50|     324|     373|       5
---------------------------------------------------------------------------
  272-  321 (49.01/17.79)	......PLiMGSHPVdnkWTPSFSSITSansvdlpacFFL.KFPQPIPVSRA....FVQKL
  322-  367 (69.04/33.04)	QnctgiPL.FETQPT...YVPLYELITQ.........FELSKDPDPIPLNHNMR..FYAAL
  371-  396 (28.14/18.11)	Q..................................hcYFLNKDA.PLPDGRSLQgtLVSKI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     314.86|      55|     151|    1248|    1302|       6
---------------------------------------------------------------------------
 1122- 1157 (49.34/12.32)	................SSKLSSSIYSSQG.SS..GSSQSKNSSQSGGKP..GSSP.IT
 1160- 1209 (71.18/21.48)	GlSSGSSSTKMKPQGKPSSLMNPSLSKPN.ISP.SHSRPPGGSDKLASPMKP......
 1248- 1302 (95.60/31.72)	G.SSGSLSQKTPPSSNSCTASSSSFSSSG.SSM.SSSQNQHGSSKGKSPSRNKKPSLT
 1367- 1412 (49.08/12.21)	G.GSVDSSKKTSESKN........VGSTGvAKI.IISKHDGGSPSIKAKVTLQKPG..
 1417- 1455 (49.67/12.46)	........EGLRPQ....MASSKNY...G.SPLiSGSTPKH..ERG.SPSHSKSPAYT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     216.23|      58|     340|     556|     613|       7
---------------------------------------------------------------------------
  556-  589 (46.46/20.10)	.......................................................PM..................SGTTTPTNTFP...GGPITTLFNM.SMSIKDRHESV
  590-  694 (68.53/34.19)	GHGEDFS.KV.SQNPILTSLLQITGNggstigssptpphhtpppvssmagntknhPMlmnllkdnpaqdfstlygSSPLERQNSSS...GSPRMEMCSG.SNKAKKKKSSR
  708-  775 (62.30/30.21)	FQRELFSmDVdSQNPIFD..VNMTAD.............................TL.........dtphitpapSQCSTPPTTYPqpvPHPQSSIQRMvRLSSSD...SI
  776-  822 (38.93/15.28)	..GPDVT.......DILSDIAEEASK.....................lpstsddcPP..................IGTPVRDSSSS...GHSQSALFD.............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     123.79|      38|      49|     146|     183|       8
---------------------------------------------------------------------------
  146-  164 (21.42/ 7.31)	..................................NFD.EFSKHLKGLVNLYNLP
  165-  213 (53.46/29.25)	GDNKLKTKMYLALQSLEQD...lskmavmywkatNAG.PLDKILHGSVG.YLTP
  216-  269 (48.91/26.13)	GGHLMNLKYYASPSDLLDDkttspiilhennvprSLGmNASVTIEGTSAMYKLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.12|      20|      23|     938|     957|       9
---------------------------------------------------------------------------
  938-  957 (36.37/17.57)	GKALGPTDLMEHHSGSQSPL
  964-  983 (30.75/13.58)	GKEKTQKRVKEGNGTSNSSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.82|      14|      22|     451|     464|      10
---------------------------------------------------------------------------
  451-  464 (25.65/14.20)	SVSFQHPVNDSLVC
  476-  489 (25.17/13.80)	SCKLYKGLSDALIC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.38|      18|     699|     122|     139|      12
---------------------------------------------------------------------------
  122-  139 (34.40/17.85)	DVKVAHHGENPVSCP.ELV
  824-  842 (29.98/14.69)	DVFQANNNENPYTDPaDLI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21037 with Med1 domain of Kingdom Metazoa
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