<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21032

Description mediator of RNA polymerase II transcription subunit 23 isoform X2
SequenceMVQMETQLQSIFEEVVKTEIIEEAFPGMFMDTPEDEKTKLISCLGAFRQFWGGLSQESHEQCIQWIVKFIHGQHSPKRISFLYDCLAMAVETGLLPPRMVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKTLTIPNTVSSAVVQQLLAAREVIAYILERNACLLPAYFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPATLRFPLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQHKQRCPVLEDQLVDLVVYAMERSETEEKFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKEFIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLKLHHEFLQQSLRNKSLQMNDYKIALLCNAYSTNSECFTLPMGALVETIYGNGIMRIPLPGTSCLASGSITPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHTLAAVAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIMSFTPHNWASHTLSCFPGPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMTNENDIITHFSAQRSPPLFLCLLWKMLLETDHINQIGYRVLERIGARALVVHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQNDWHTKHMNYHKKYPEKLYFEGLAEQVDPPVPIQSPYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYEMHLRNRESLKRKLVHAIIGSLKDNRPQGWCLSDTYLKCAMNAREDNPWVPDDSYYCKLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVSGQDVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDRIVSVISSPSLTSETEWVGYPFRLFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEVLLPIVKTEFQLLYVYHLVGPFLQRFQQERTRCMIEIGVAFYDMLLNVDQCSTHLNYMDPICDFLYHMKYMFTGDSVKEQVEKIICNLKPALKLRLRFITHISKMEPAAVPPQAVSSGSPAPQSNQVPVSLPVTQ
Length1371
PositionTail
OrganismDelphinapterus leucas (Beluga whale)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Whippomorpha> Cetacea> Odontoceti> Monodontidae> Delphinapterus.
Aromaticity0.10
Grand average of hydropathy-0.007
Instability index46.18
Isoelectric point7.09
Molecular weight156679.41
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21032
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     141.88|      45|     262|     974|    1019|       1
---------------------------------------------------------------------------
  974- 1019 (79.43/57.44)	IHRFL..eLLPVSKSLETLL..DHLGG..LYKF.HDRPVTYLYNTLHYYEMHL
 1230- 1282 (62.46/39.83)	IPKFLtevLLPIVKTEFQLLyvYHLVGpfLQRFqQERTRCMIEIGVAFYDMLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.87|      21|     127|     587|     611|       2
---------------------------------------------------------------------------
  587-  607 (36.35/26.00)	FISQLLPTVFKSHAWGILHTL
  613-  633 (38.51/17.53)	YRMHHIQPHYRVQLLSHLHTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     147.44|      46|     262|     525|     576|       3
---------------------------------------------------------------------------
  525-  576 (66.24/61.27)	PLPMNLLDSLTVHAKMslIHSIATRVIKLAHAKSSValapALVETYSRLLVY
  790-  835 (81.20/56.69)	PLFLCLLWKMLLETDH..INQIGYRVLERIGARALV....VHVRTFADFLVY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     137.48|      40|     524|     152|     256|       6
---------------------------------------------------------------------------
  191-  233 (65.76/117.65)	RKLYPEgKLPHWLLGNLVSDFVDTFRPTARI..NSICGRcsLLPV
  928-  969 (71.72/17.33)	HKKYPE.KLYFEGLAEQVDPPVPIQSPYLPIyfGNVCLR..FLPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.26|      35|     301|     850|     887|       7
---------------------------------------------------------------------------
  850-  887 (58.17/42.22)	IEILNDMVWkynIVTLDRLILCLAMRSHEGNEAQVCY.F
 1156- 1191 (59.10/34.86)	ITALPEPYW...IVLHDRIVSVISSPSLTSETEWVGYpF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.14|      10|      31|     342|     351|       8
---------------------------------------------------------------------------
  342-  351 (18.69/11.21)	IFFVLFQFAS
  375-  384 (19.45/11.99)	LMWVLLQFIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     150.03|      45|     711|      32|      76|       9
---------------------------------------------------------------------------
   32-   76 (86.47/49.26)	TPEDEKTKLISCL.GAFRQFW..GGLSQES........HEQCIQW........IVKFIHGQHSP
  726-  789 (63.56/34.41)	TPHNWASHTLSCFpGPLQAFFkqNNVPQESrfnlkknvEEEYRKWksmtnendIITHFSAQRSP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21032 with Med23 domain of Kingdom Metazoa
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