<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21031

Description cyclin-dependent kinase 19 isoform X3
SequenceMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFQEDPLPTLDVFAGCQIPYPKREFLNEDEPEEKGDKNQQQQQNQHPQPAAPPQQAAAPPQAAPQQQNSTQANGTAGGAGAGPGATGAGLQHSQDSGLNQVPPNKKPRLGPSGTNSGGPAMPSDYQHSSSRLNYQSSVQGSSQSQSSLGYSSSSQQSAQYHPSHQAHRY
Length442
PositionKinase
OrganismDelphinapterus leucas (Beluga whale)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Whippomorpha> Cetacea> Odontoceti> Monodontidae> Delphinapterus.
Aromaticity0.08
Grand average of hydropathy-0.648
Instability index57.87
Isoelectric point8.79
Molecular weight49751.73
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
protein kinase activity	GO:0004672	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21031
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     122.76|      28|      41|     373|     400|       1
---------------------------------------------------------------------------
  332-  365 (29.08/10.66)	..PPQAAPQQqnstqanG.TAGGAGAGPgATGAGLQH
  373-  400 (53.36/24.78)	QVPPNKKPRL.......G.PSGTNSGGP.AMPSDYQH
  412-  440 (40.33/17.20)	QGSSQSQSSL.......GySSSSQQSAQ.YHPSHQAH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.44|      15|      41|      91|     105|       2
---------------------------------------------------------------------------
   91-  105 (26.77/17.41)	DLKPANILVMGEGPE
  129-  143 (28.67/19.11)	DLDPVVVTFWYRAPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.61|      28|      41|     254|     281|       3
---------------------------------------------------------------------------
  254-  281 (48.12/25.57)	KLLTMD.PTKRITSEQALQDPYFQEDPLP
  297-  325 (45.49/23.81)	EFLNEDePEEKGDKNQQQQQNQHPQPAAP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21031 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) YPKREFLNEDEPEEKGDKNQQQQQNQHPQPAAPPQQAAAPPQAAPQQQNSTQANGTAGGAGAGPGATGAGLQHSQDSGLNQVPPNKKPRLGPSGTNSGGPAMPSDYQHSSSRLNYQSSVQGSSQSQSSLGYSSSSQQSAQYHPSHQAHRY
293
442










Molecular Recognition Features






MoRF SequenceStartStop




1) QSSLGYSSSSQQSAQYHPSHQAHRY
2) SRLNYQSSVQ
3) VPPNKKPRLGP
418
403
374
442
412
384