<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21023

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMEAGPVFPSGWKLLGPAFSAPPCTPCPDNKKSQASVSDPMNALQSLTGGPAAGAAGIGLPARGPGQPLGGMGGLGAMGQPMPLSGQPPPGTSGMAPHGMAVVSTAAPQTQLQLQQVALQQQQQQFQAQQQAALQQQQQQQFQVQQSAMQQQFQAVVQQQQLQQQQQQQHLIKLHHQNQQQMQQQQQQQLQRMAQLQLQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQLHHPQHHQPPPQPQPPVAQNQPSQLPPQSQTQPLVSQAPALPGQMLYAQPQLKLVRAPMVVQQPQVQPQVPQVQPQVPPQTAVPTAQASQIVGPGVQVSQSGLTMLSSPSPGQQVQTPQSMPPPPQPSPQPGPPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCTRKRRFEEDERQSIPNVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSIHQACLSAA
Length700
PositionTail
OrganismDelphinapterus leucas (Beluga whale)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Whippomorpha> Cetacea> Odontoceti> Monodontidae> Delphinapterus.
Aromaticity0.03
Grand average of hydropathy-0.651
Instability index90.86
Isoelectric point9.16
Molecular weight76221.91
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21023
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.98|      28|      38|     196|     233|       3
---------------------------------------------------------------------------
  196-  233 (43.16/16.94)	QLQQQQQQQQQQqqalqaqPPIQ.QPPMQQPQPppSQaL
  236-  264 (45.81/ 6.25)	QLQQLHHPQHHQ.......PPPQpQPPVAQNQP..SQ.L
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.95|      19|      22|     386|     405|       5
---------------------------------------------------------------------------
  386-  405 (35.30/14.12)	APSPSSFlPSPSPQPSQSPV
  407-  425 (34.65/10.23)	ARTPQNF.SVPSPGPLNTPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     113.30|      22|      22|      53|      74|       6
---------------------------------------------------------------------------
   45-   66 (37.17/17.57)	SLTGGPAAGAAGIGLPARGPGQ
   67-   86 (38.15/18.26)	PLGGMGGLGAMGQPMPL..SGQ
   87-  108 (37.98/18.14)	PPPGTSGMAPHGMAVVSTAAPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      92.10|      19|      22|     269|     290|       7
---------------------------------------------------------------------------
  151-  167 (30.37/ 7.26)	QFQA.VVQQQQLQQQ....QQQ
  269-  290 (31.26/13.56)	QTQPLVSQAPALPGQmlyAQPQ
  311-  328 (30.47/ 7.30)	QVQPQVPPQTAVPT....AQAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.17|      16|      35|     333|     348|       8
---------------------------------------------------------------------------
  333-  348 (28.69/13.84)	PGVQVSQSGLTMLSSP
  370-  385 (31.48/16.06)	PGPPSSQPNSNVSSGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.40|      23|      28|     475|     501|       9
---------------------------------------------------------------------------
  466-  493 (35.23/21.67)	DKNEdrkkdLSKMKSLLDILTDPSKRCP
  498-  522 (39.17/16.19)	QKCE...iaLEKLKNDMAVPTPPPPPVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.76|      17|     546|       8|      24|      12
---------------------------------------------------------------------------
    8-   24 (35.66/17.95)	PSGWKLLGPAFSAP.PCT
  556-  573 (30.10/13.99)	PAMTAIHGPPITAPvVCT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21023 with Med15 domain of Kingdom Metazoa
Unable to open file!