<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21019

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSSSFVPNGASLEDCHCNLFCLADLTGIKWKRYVWQGPTSAPILFPVTEEDPILSSFSRCLKADVLGVWRRDQRPGRRELWIFWWGEDPNFADLIHHDLSEEEDGVWENGLSYECRTLLFKAVHNLLERCLMNRNFVRIGKWFVKPYEKDEKPINKSEHLSCSFTFFLHGDSNVCTSVEINQHQPVYLLSEEHITLAQQSNSPFQVILSPFGLNGTLTGQAFKMSDSATKKLIGEWKQFYPVSSCLKEMSEEKQEDMDWEDDSLAAVEVLVAGVRMIYPACFVLVPQSDIPTPSSVGSSHCSASCLGVHQVPASTRDPAMSSVTLTPPTSPEEVQTVDPQSAQKWITFSSVSDGFSSDSTSHHGGKIPRKLANHVVDRVWQECNLNRAQNKRKYSASSGGLCEEETADKVASWDFVEATQRTNCSCLRHKNLKARNPGQQGQAPTLSQQQQVLPKHKTNEKQEKSEKPQKRPLTPFHHRVSVSDDVGMDADSASQRLVISAPDSQVRFSNIRTNDVAKTPQMHGTEMANSPQPPPLSPHPCDVVDEGVTKTPSTPQSQHFYQMPTPDPLVPSKPIEDRIDSLSQSFPAQFQEAVEPTIYVGTAVNLEEDEANIAWKYYKVPKKKDLEFLPPQLPSDKFKDDPVGPFGQESVTSVTELMVQCKKPLKVSDELVQQYQIKNQYLSAIASDSEQEPKIDPYAFVEGDEEFLFPDKKERQNNEREAGKKHKVEDVPSSVTVLSHEEDAMSLFSPSIKQDAPRPTSHARPPSTSLIYDSDLAVSYTDLDNLFNSDEDELTPGSKKSANGSDDKSSCKESKTGNLDPLSCISTADLHKMYPTPPSLEQHIMGFSPMNMNNKEYGSMDTTPGGTVLEGNSSSIGAQFKIEVDEGFCSPKPSEIKDFSYVYKPENCQVLVGCSMFAPLKTLPSQCLPTIKLPEECIYRQSWTVGKLELLPSGPTMPFIKEGDGSTLDQEYGPAYTPQTHASFGMPPSSAPPSNSGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENSDLYSPASTPSTCRPLNSVEPATVPSIPEAHSLYVNLILSESVMNLFKDCNFDSCCICVCNMNIKGADVGVYIPDPTQEAQYRCTCGFSAVMNRKFGNNSGLFLEDELDIIGRNTECGKEAEKRFEAPRATSAEHVNGGLKESEKLPDELILLLQDQCTNLFSPFGAADQDPFPKIGVTNNWVRVEERDCCNDCYLALEHGRQFMDNMSGGKVDEALVKSSCLHPWSKRNDVSMQCSQDILRMLLSLQPVLQDAIQKKRTVRPWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLLGYDFDFLVLSPFALPYWERLMLEPYGSQRDIAYVVLCPENEALLNGAKSFFRDLTAIYESCRLGQHRPISRLLTDGIMRVGSTASKKLSEKLVAEWFSQAADGNSEAFSKLKLYAQVCRYDLGPYLASQPLDSSLLSQPNLVAPTSQPLITPPQMTSTGNANIPSATLAPTASSTVTVTSGVAMSSSVATANSTLTTTSASSSSSSNLNSGMSSNKLPSFPPFGSMNSSVAGSMSTQASTVQNGQLGGQPPSALQTAGISGESSSIPTQPHPDVSESTMDRDKVGIPTDGDSHAITYPPAIVVYIIDPFTYENKDESTNSSNVWTLGLLRCFLEMVQTLPPHVKSTVSVQIVPCQYLLQPVKHEDRQIYTQHLKSLAFSAFTQCRRPLPTSTNVKTLTGFGPGLAMETALKSPDRPECIRLYTPPFILAPVKDKQTELGETFGEAGQKYNVLFVGYCLSHDQRWILASCTDLYGELLETCIINIDVPNRARRKKGSARRFGLQKLWEWCLGLVQMSSLPWRVVIGRLGRIGHGELKDWSCLLSRRNLQSLSKRLKDMCRMCGISAADSPSILSACLVAMEPQGSFVIMPDSVSTGSVFGRSTTLNMQTSQLNTPQDTSCTHILVFPTSASVQVASATYTTENLDLAFNPNNDGADGMGIFDLLDTGDDLDPDIINILPASPTGSPVHSPGSHYPHGGDAGKGQGTDRLLSTESHDEVTNILQQPLALGYFVSTAKAGPLPDWFWSACPQAQYQCPLFLKASLHLHVPSVQSDELLHSKHSHPLDSNQTSDVLRFVLEQYNALSWLTCDPAIQDRRSCLPIHFVVLNQLYNFIMNML
Length2174
PositionMiddle
OrganismDelphinapterus leucas (Beluga whale)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Whippomorpha> Cetacea> Odontoceti> Monodontidae> Delphinapterus.
Aromaticity0.08
Grand average of hydropathy-0.395
Instability index53.42
Isoelectric point5.39
Molecular weight239358.37
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription coactivator activity	GO:0003713	IEA:Ensembl

GO - Biological Process
cholesterol homeostasis	GO:0042632	IEA:Ensembl
negative regulation of DNA-binding transcription factor activity	GO:0043433	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
triglyceride homeostasis	GO:0070328	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21019
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     347.72|     107|     320|     473|     599|       1
---------------------------------------------------------------------------
  473-  591 (182.24/105.90)	LTPFHHR.VSVSDDVGMDADSASQRLvisAPdsqvrFSNIRTNDVAKTPQMHgtemAN.SPQPPPLSPH.....PCDVVDEGVTKTPSTPQ..SQHFYQMP.TP....DPLVPSKPIE.DRIDSLS.QSFPAQFQ
  794-  864 (81.82/31.89)	LTPGSKKsANGSDDKSSCKESKTGNL...DP.....LSCISTADLHK...........mYPTPPSLEQHimgfsPMNMNNKEYGSMDTTP.............................................
  975- 1052 (83.66/33.31)	.............................................AYTPQTH....AS.FGMPPSSAP......PSN.SGAGILPSPSTPRfpTPRTPRTPrTPrgagGPASAQGSVKyENSDLYSpASTPSTCR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     206.30|      64|     321|    1617|    1681|       2
---------------------------------------------------------------------------
 1617- 1681 (109.71/85.15)	MDRDKVGIPTDGD.SHAITYPPAIVVYIID.pFTYENKDESTNSSNVWTLGL.LRCFLEMVQTLPPHV
 1944- 2011 (96.59/68.84)	MQTSQLNTPQDTScTHILVFPTSASVQVASatYTTENLDLAFNPNNDGADGMgIFDLLDTGDDLDPDI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.11|      15|      17|    1509|    1525|       3
---------------------------------------------------------------------------
 1509- 1525 (22.22/20.09)	TASSTVTVTSgvAMSSS
 1528- 1542 (26.90/16.56)	TANSTLTTTS..ASSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     149.71|      47|     533|    1225|    1310|       4
---------------------------------------------------------------------------
 1252- 1301 (70.21/100.11)	DEaLVKSSCLHPWSKrNDVSmQCSQDILRMLLSLQPVLQD.AIQKKRTVRP
 2110- 2157 (79.50/29.51)	DE.LLHSKHSHPLDS.NQTS.DVLRFVLEQYNALSWLTCDpAIQDRRSCLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     250.88|      61|     257|      17|      82|       5
---------------------------------------------------------------------------
   17-   79 (106.98/53.68)	CnlFCLADLTGIKWKRYVWQGPTSAPIL....FPVTEEDPILSSFSRCLKADVLG...VWRRDQRPGRRE
  281-  322 (47.99/16.37)	C..FVLVPQSDIPTPSSVGSSHCSASCLgvhqVPASTRDPAMSS..........................
  888-  949 (95.92/44.74)	...FCSPKPSEIKDFSYVYK.PENCQVL....VGCSMFAPLKTLPSQCLPTIKLPeecIYRQSWTVGKLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.62|      15|      19|    1462|    1478|       6
---------------------------------------------------------------------------
 1462- 1478 (23.07/16.57)	PylASQPL..DSSLLSQPN
 1482- 1498 (25.54/11.53)	P..TSQPLitPPQMTSTGN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.31|      11|      19|    1322|    1332|       7
---------------------------------------------------------------------------
 1322- 1332 (22.98/11.83)	YGTD...ESPEPLP
 1340- 1353 (17.33/ 6.83)	YDFDflvLSPFALP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     235.97|      75|     460|     703|     786|       8
---------------------------------------------------------------------------
  709-  786 (115.84/90.76)	FPDKKERQNNEREAGKKHKvEDVPSSVtVLSHEEDAMSLFSP..SIKQDaPRP.....TSHARPPSTSLIYDSDLAVSYTD..LDNL
 1163- 1246 (120.13/69.28)	FEAPRATSAEHVNGGLKES.EKLPDEL.ILLLQDQCTNLFSPfgAADQD.PFPkigvtNNWVRVEERDCCNDCYLALEHGRqfMDNM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.01|      17|      19|    1544|    1562|      10
---------------------------------------------------------------------------
 1544- 1560 (31.78/21.54)	SNLNSGMSSN.......KLPSFPP
 1566- 1589 (24.23/ 7.29)	SSVAGSMSTQastvqngQLGGQPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.94|      23|      37|    1756|    1779|      13
---------------------------------------------------------------------------
 1756- 1779 (38.36/34.03)	CIRlYTPPFILAPVKDKQTELGET
 1795- 1817 (43.59/33.35)	CLS.HDQRWILASCTDLYGELLET
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21019 with Med13 domain of Kingdom Metazoa
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