<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21018

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQSLTGGPAAGAAGIGLPARGPGQPLGGMGGLGAMGQPMPLSGQPPPGTSGMAPHGMAVVSTAAPQTQLQLQQVALQQQQQQFQAQQQAALQQQQQQQFQVQQSAMQQQFQAVVQQQQLQQQQQQQHLIKLHHQNQQQMQQQQQQQLQRMAQLQLQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQLHHPQHHQPPPQPQPPVAQNQPSQLPPQSQTQPLVSQAPALPGQMLYAQPQLKLVRAPMVVQQPQVQPQVPQVQPQVPPQTAVPTAQASQIVGPGVQVSQSGLTMLSSPSPGQQVQTPQSMPPPPQPSPQPGPPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCTRKRRFEEDERQSIPNVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSIHQACLSAA
Length716
PositionTail
OrganismDelphinapterus leucas (Beluga whale)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Whippomorpha> Cetacea> Odontoceti> Monodontidae> Delphinapterus.
Aromaticity0.03
Grand average of hydropathy-0.663
Instability index87.70
Isoelectric point9.50
Molecular weight78471.51
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21018
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.11|      28|      38|     212|     249|       3
---------------------------------------------------------------------------
  212-  249 (43.94/17.59)	QLQQQQQQQQQQqqalqaqPPIQ.QPPMQQPQPppSQaL
  252-  280 (47.17/ 7.07)	QLQQLHHPQHHQ.......PPPQpQPPVAQNQP..SQ.L
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.98|      19|      22|     402|     421|       5
---------------------------------------------------------------------------
  402-  421 (34.71/11.61)	APSPSSFlPSPSPQPSQSPV
  423-  441 (33.26/ 7.86)	ARTPQNF.SVPSPGPLNTPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     147.34|      22|      22|      69|      90|       6
---------------------------------------------------------------------------
   80-   99 (31.08/ 9.49)	PGQPLGGMGGLGAM...GQPMPL..
  100-  121 (34.20/11.40)	SGQPPPGTSGMAPH...GMAVVSTA
  297-  317 (29.63/ 8.59)	PGQMLYAQPQLKLV...RAPMVV.Q
  318-  342 (25.53/ 6.07)	QPQVQPQVPQVQPQvppQTAVPTAQ
  343-  364 (26.90/ 6.92)	ASQIVGPGVQVSQS...GLTMLSSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.87|      16|      47|     528|     543|       7
---------------------------------------------------------------------------
  528-  543 (33.17/13.04)	AVPTPP.PPPVPPTKQQ
  576-  592 (26.70/ 8.89)	AIHGPPiTAPVVCTRKR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      56.70|      14|     117|     495|     508|       9
---------------------------------------------------------------------------
  461-  474 (22.52/13.16)	LDKLKQLSKYI....EPL
  481-  497 (14.75/ 6.36)	IDKNEDRKKD.lskmKSL
  498-  513 (19.44/10.46)	LDILTDPSKRC..plKTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.66|      14|     112|     281|     294|      10
---------------------------------------------------------------------------
  281-  294 (27.66/12.32)	PPQSQTQPLVSQAP
  388-  401 (27.99/12.58)	PPSSQPNSNVSSGP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21018 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HNKKSQASVSDPMNALQSLTGGPAAGAAGIGLPARGPGQPLGGMGGLGAMGQPMPLSGQPPPGTSGMAPHGMAVVST
2) QQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQLHHPQHHQPPPQPQPPVAQNQPSQLPPQSQTQPLVSQAPALPGQMLYAQPQLKLVRAPMVVQQPQVQPQVPQVQPQVPPQTAVPTAQASQIVGPGVQVSQSGLTMLSSPSPGQQVQTPQSMPPPPQPSPQPGPPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQ
44
221
120
466










Molecular Recognition Features






MoRF SequenceStartStop




NANANA