<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21017

Description mediator of RNA polymerase II transcription subunit 25 isoform X6
SequenceMVPGSEGPARAGGLVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSSAYEFVTWLDGIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGYTTESLVQKIGEQGIHFSIVSPRKLPALRLLFEKAAPPALLEPLQPPADVSQDPRHMVLVRGLVLPVGGGSAPGPLQPKQPVPLPPAAPSGASLSAAPQQPLPPVPQQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPINPLQAAPGVGPPFSQAPAPPLPPGPPGAPKPPPASQPSLVSTVAPGPGLAPPAQPGAPSMAGSVAPGGVSGPSPAQLGAPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHKQVQQQKLEQQRGMGAQQAPPGLGPILEDQARPSQNLLQLRPPQPQPQGTVGASAASGQPQPQGAAQAPPGAPQGPPGAAPGPPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPAPQASLHHLQPPGAPALLPPPHQGLGQPQLGPPLLHPPPAQSWPTQLPPRAPLPGQMLLSGGPRGPVPQPGLQPSVMEDDILMDLI
Length745
PositionUnknown
OrganismEnhydra lutris kenyoni
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Mustelidae> Lutrinae> Enhydra.
Aromaticity0.05
Grand average of hydropathy-0.231
Instability index59.88
Isoelectric point8.64
Molecular weight77845.52
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21017
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.10|      20|      23|     595|     617|       4
---------------------------------------------------------------------------
  246-  268 (27.20/ 8.26)	PLPPAAPS...GasLSAAPQQPlPPV
  610-  632 (40.90/ 8.55)	QAPPGAPQgppG..AAPGPPPP.GPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.27|      30|     110|      39|      69|       5
---------------------------------------------------------------------------
   39-   69 (53.43/35.62)	YLLPAIEYFN.GGPPAETdFGGDYG..GTQYSLV
  151-  183 (43.84/24.05)	YLLPAVESTTySGYTTES.LVQKIGeqGIHFSIV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     150.06|      29|      30|     185|     213|       7
---------------------------------------------------------------------------
  185-  209 (35.83/ 8.00)	.......PRKLPALR...LLFEKAAPPALLEPLQP
  210-  244 (39.28/ 9.59)	PADVsqdPRHMVLVRglvLPVGGGSAPGPLQPKQP
  573-  590 (33.27/ 6.82)	QAR....PSQ....N...LL..QLRPP...QP.QP
  709-  733 (41.68/10.70)	RAPL...PGQM.......LLSGGPRGPVPQPGLQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     135.88|      42|      70|     445|     494|       8
---------------------------------------------------------------------------
  436-  471 (60.04/25.67)	....ENLKT......EQWP.......................QKLIMQLIP..........QQLLTTLGPLFRNSRMVQ
  476-  547 (36.31/25.67)	NKDLESLKGlyriMGNGFAgcvhfphtapcevrvlmllysskKKIFMGLIPydqsgfvngiRQVIT.......NHKQVQ
  548-  572 (39.53/12.25)	QQKLEQQRG....MGAQQA...............................P..............PGLGPILED.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      70.34|      16|     282|     378|     393|      10
---------------------------------------------------------------------------
  371-  384 (19.96/ 6.60)	..APGGVSGPSPAQLG
  385-  400 (24.64/10.27)	APALGGQQSVSNKLLA
  402-  417 (25.73/11.13)	SGVLEWQEKPKPASVD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.83|      30|     269|       2|      32|      11
---------------------------------------------------------------------------
    2-   32 (48.90/28.65)	VPGSEGPARAGGLVAdVVFVIEGTANLGPYF
  274-  303 (50.93/25.83)	VPGNLSAAQVAAQNA.VEAAKNQKAGLGPRF
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21017 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GGSAPGPLQPKQPVPLPPAAPSGASLSAAPQQPLPPVPQQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPINPLQAAPGVGPPFSQAPAPPLPPGPPGAPKPPPASQPSLVSTVAPGPGLAPPAQPGAPSMAGSVAPGGVSGPSPAQLGAPALG
2) HKQVQQQKLEQQRGMGAQQAPPGLGPILEDQARPSQNLLQLRPPQPQPQGTVGASAASGQPQPQGAAQAPPGAPQGPPGAAPGPPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPAPQASLHHLQPPGAPALLPPPHQGLGQPQLGPPLLHPPPAQSWPTQLPPRAPLPGQMLLSGGPRGPVPQPGLQPSVMEDDILMD
232
543
389
743










Molecular Recognition Features






MoRF SequenceStartStop




NANANA