<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21016

Description mediator of RNA polymerase II transcription subunit 25 isoform X1
SequenceMVPGSEGPARAGGLVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSSAYEFVTWLDGIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGYTTESLVQKIGEQGIHFSIVSPRKLPALRLLFEKAAPPALLEPLQPPADVSQDPRHMVLVRGLVLPVGGGSAPGPLQPKQPVPLPPAAPSGASLSAAPQQPLPPVPQQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPINPLQAAPGVGPPFSQAPAPPLPPGPPGAPKPPPASQPSLVSTVAPGPGLAPPAQPGAPSMAGSVAPGGVSGPSPAQLGAPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLVSGPRGHRPPLRSAGRILFPRPLPAPHLPPSLLLPSPLRTPARVSPVSPADHPGPFVPELEDGAVPLHQQGPGVPERPLPHHGQRLCRLRALPPHGPLRGARAHAALLVQEEDLHGPHPLRPERLRQRHPAGHHQPQASPAAEAGAAARDGGTAGTPWAGPHSGGPGETLTESAPAPPTTAPASGHCGGLRSLRTAPAPRCCPGPPRRPPRPSWSSPWPSPSWTHPPASEPWGQPPTAESPPQPTSAPDWGACTPSLPPPPPATGGSCTVAPTTPGSGATPAGAPPPAPTACPVLAHTASPESSTARSDAAERGSPGPGSPAGPAAQRHGGRHPHGSHLNPRHPIKFLLTHAPAPVTDVPQDWAGGDLGETSLSLFLLQQMSLRLWAGDAWAPAVSQAVWCSPALGRGGWDVKAGRQSSQGRAPSRR
Length884
PositionUnknown
OrganismEnhydra lutris kenyoni
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Mustelidae> Lutrinae> Enhydra.
Aromaticity0.05
Grand average of hydropathy-0.346
Instability index69.78
Isoelectric point8.86
Molecular weight91357.57
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21016
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     855.59|     107|     107|     529|     635|       1
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  136-  249 (90.83/13.44)	...................GQthRV...CLLiCNSP.PYlLPAVESTTYSGYttesLV.....QkigEQGIHfsivSP.R..KLP.A..LRLlfEKAAPPALL.EP.LQPP....ADVSQDPRHmvlvRG...LV.LPVGG.........GSAPGPLQP.KQPVPLPP
  252-  338 (111.52/18.48)	PSgaslsaAPQQP..LPPVPQ..Q........YQVP....GNLSAAQVAAQN....AVeaaknQ...KAGL.....GP.RfsPIN.P....L..QAAPGVG....P...PF....SQAPAP................PLP............PGPPG......APKPP
  343-  430 (113.36/18.93)	PS......LVSTV..APGPGL............A.P.PA.QP..GAPSMAG.....SV.....A...PGGVS....GP......S.P..AQL..GA..PALGG.QQSVSNK....LLA....................WSGvlewqekpkPASVDANTKLTRSLPCQV
  461-  528 (92.94/13.96)	PR......GHRPP..LRSAG...RI...LFP.RPLPaPH.LP.......PSL....LL...................P.S..PLRtP..ARV..SPVSPADHP.GPFV.PE....LEDGA..............V..PL............HQQG.............
  529-  635 (202.48/40.64)	PG......VPERP..LPHHGQ..RL...CRL.RALP.PH.GPLRGARAHAAL....LV.....Q...EEDLH....GP.H..PLR.P..ERL..RQRHPAGHH.QPQASPA....AEAGAAARD....GG...TAGTPWAG.........PHSGGPGETLTESAPAPP
  639-  718 (130.10/23.01)	PA.......................sghC...........GGLRSLRTAPA................PRCCP....GP....PRR.P..PR.......PS.WS.SPWPSPS....WTHPPASEP....WGqppTAESP.PQ.........PTSAPDWGACTPSLPPPP
  732-  828 (114.37/19.18)	PG......SGATPagAPPPAP..TA...CPV.LAHT.AS.PESSTARSDAA................ERGSP....GPgS..PAG.PaaQRH..GGRHPHGSHlNPR.HPIkfllTHAPAPVTD..........VPQDWAG............GDLGET.........
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21016 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GGSAPGPLQPKQPVPLPPAAPSGASLSAAPQQPLPPVPQQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPINPLQAAPGVGPPFSQAPAPPLPPGPPGAPKPPPASQPSLVSTVAPGPGLAPPAQPGAPSMAGSVAPGGVSGPSPAQLGAPALGGQQ
2) LPPSLLLPSPLRTPARVSPVSPADHPGPFVPELEDGAVPLHQQGPGVPERPLPHHGQRLCRLRALPPHGPLRGARAHAALLVQEEDLHGPHPLRPERLRQRHPAGHHQPQASPAAEAGAAARDGGTAGTPWAGPHSGGPGETLTESAPAPPTTAPASGHCGGLRSLRTAPAPRCCPGPPRRPPRPSWSSPWPSPSWTHPPASEPWGQPPTAESPPQPTSAPDWGACTPSLPPPPPATGGSCTVAPTTPGSGATPAGAPPPAPTACPVLAHTASPESSTARSDAAERGSPGPGSPAGPAAQRHGGRHPHGSHLNPRHPIKFLLTHAPAPVTDVPQDWAG
232
485
392
822










Molecular Recognition Features






MoRF SequenceStartStop




1) PIKFLL
801
806