<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21015

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMDVSGQETDWRSAAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQSLTGGPAAGAAGIGLPARGPGQPLGGMGGLGAMGQPMPLSGQPPPGTSGMAPHGMAVVSTAAPQTQLQLQQVALQQQQQQFQAQQQAALQQQQQQQFQVQQSAMQQQFQAVVQQQQLQQQQQQQHLIKLHHQNQQQMQQQQQQQLQRMAQLQLQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQLHHPQHHQPPPQPQPPVAQNQPSQLPPQSQTQPLVSQAPALPGQMLYAQPQLKLVRAPMVVQQPQVQPQVPQVQPQVPPQTAVPTAQASQIVGPGVQVSQSGLTMLSSPSPGQQVQTPQSMPPPPQPSPQPGPPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCTRKRRFEEDERQSIPNVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSIHQACLSAA
Length742
PositionTail
OrganismDelphinapterus leucas (Beluga whale)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Whippomorpha> Cetacea> Odontoceti> Monodontidae> Delphinapterus.
Aromaticity0.03
Grand average of hydropathy-0.665
Instability index87.09
Isoelectric point9.38
Molecular weight81421.71
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21015
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.11|      28|      38|     238|     275|       3
---------------------------------------------------------------------------
  238-  275 (43.94/20.86)	QLQQQQQQQQQQqqalqaqPPIQ.QPPMQQPQPppSQaL
  278-  306 (47.17/ 8.42)	QLQQLHHPQHHQ.......PPPQpQPPVAQNQP..SQ.L
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.98|      19|      22|     428|     447|       5
---------------------------------------------------------------------------
  428-  447 (34.71/13.29)	APSPSSFlPSPSPQPSQSPV
  449-  467 (33.26/ 9.04)	ARTPQNF.SVPSPGPLNTPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      89.99|      21|      22|      95|     116|       6
---------------------------------------------------------------------------
  106-  125 (31.48/ 8.17)	PGQPLGGMGGLGAMGQPMPL..
  126-  147 (28.87/ 9.83)	SGQPPPGTSGMAPHGMAVVStA
  323-  343 (29.63/ 7.39)	PGQMLYAQPQLKLVRAPMVV.Q
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     211.23|      68|     117|     521|     594|       7
---------------------------------------------------------------------------
  521-  591 (115.04/55.21)	KSLLDIltDPSKrCPLK.TLQ.KCEIALEKLKN....DMAVPT..PPPPPVPPTKQ.QYLCQPLLDAVLANIRSPVF....NHS
  642-  722 (96.20/34.84)	KFLVNL..DPSH.CSNNgTVHlICKLDDKDLPSvpplELSVPAdyPAQSPLWIDRQwQYDANPFLQSVHRCMTSRLLqlpdKHS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.36|      14|      21|     181|     194|       9
---------------------------------------------------------------------------
  181-  194 (26.16/ 8.89)	QQFQVQQSAMQQQF
  199-  212 (26.20/ 8.92)	QQQQLQQQQQQQHL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.40|      15|      53|     357|     375|      10
---------------------------------------------------------------------------
  344-  358 (29.26/13.61)	QPQV.QPQVPQ.VQPQV
  361-  377 (17.14/ 7.72)	QTAVpTAQASQiVGPGV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21015 with Med15 domain of Kingdom Metazoa
Unable to open file!