<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21009

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMDLAYVCEWERWPKSTHCPSVPLACAWSCRNLIAFTTDLRNDDQDLTRVIHILDTEHPWDVHSVSSEHSEAITCLEWDQSGSRLLSADADGQIKCWSMADHLANSWESHVGSLVEGDPIVALSWLHNGVKLALHVEKSGASSFGEKFSRVKFSPSLTLFGGKPMEGWIAVTVSGLVTVSLLKPSGQVLTSTESLCRLRGRVALADIAFTGGGNIVVATADGSSASPVQFYKVCVSVVSEKCRIDTEILPSLFMRCTTDLNRKDKFPAITHLKFLARDMSEQVLLCASSQTSSIVECWSLRKEGLPVNNVFQQISPVVGDKQPMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLGLALAFHDGSVHIVHRLSLQSMAVFYNSAAPRSADEPAIKRPRASGPAVHFKAMQLSWTSLALVGIDNHGKLSMLRISPSMGHTLDVSLALRHLLFLLEYCMVTGYDWWDTLLHVQPAMVQSLVEKLHEEYTRQNAALQQVLSTRILAMKASLCKLSPCTVARVCDYHAKLFLVAVSSTLKSLLRPHFLNTPDKSPGDRLTEVCSKITDADIDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFVLYLLASLPNQGSPLRPGHSFLRDGPSLGLLRELMVVIRIWGLLKPGCLPVYTATSDTQDSMSLLFRLLTKLWICCRDEGPTSEPDEALVDECCLLPSQLLIPSLDWLPVSDGLVSRLQPKQPLRLHFGKAPPLPAGAGALPLDGLVRAGQPKVDHLRRLHLGAFPTEECKTCTRCGCVTMLRSPNKTTAVKQWEQRWIKNCLCGGLWRRAPLSCP
Length828
PositionTail
OrganismEnhydra lutris kenyoni
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Mustelidae> Lutrinae> Enhydra.
Aromaticity0.07
Grand average of hydropathy0.038
Instability index48.34
Isoelectric point7.71
Molecular weight91395.03
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
catalytic activity	GO:0003824	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21009
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.67|      16|     188|     441|     463|       1
---------------------------------------------------------------------------
  441-  463 (24.54/24.04)	SMLRISPSMGHtldvslaLRHLL
  632-  647 (30.13/15.03)	SFLRDGPSLGL.......LRELM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.19|      24|      31|     720|     744|       2
---------------------------------------------------------------------------
  720-  744 (43.17/31.62)	LPVsDGLVSRLQPK.QPL.RLHFGKAP
  753-  778 (39.02/23.52)	LPL.DGLVRAGQPKvDHLrRLHLGAFP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.91|      13|      24|     304|     316|       3
---------------------------------------------------------------------------
  304-  316 (22.81/17.05)	LPVNNVFQQISPV
  330-  342 (20.10/14.09)	LSATNDLDRVSAV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.79|      28|     188|      71|     106|       5
---------------------------------------------------------------------------
   71-   98 (54.19/35.84)	AITCLEW...DQSGSRLL..SADADGQIKCWSM
  267-  299 (40.60/13.81)	AITHLKFlarDMSEQVLLcaSSQTSSIVECWSL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21009 with Med16 domain of Kingdom Metazoa
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