<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21008

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMDLAYVCEWERWPKSTHCPSVPLACAWSCRNLIAFTTDLRNDDQDLTRVIHILDTEHPWDVHSVSSEHSEAITCLEWDQSGSRLLSADADGQIKCWSMADHLANSWESHVGSLVEGDPIVALSWLHNGVKLALHVEKSGASSFGEKFSRVKFSPSLTLFGGKPMEGWIAVTVSGLVTVSLLKPSGQVLTSTESLCRLRGRVALADIAFTGGGNIVVATADGSSASPVQFYKVCVSVVSEKCRIDTEILPSLFMRCTTDLNRKDKFPAITHLKFLARDMSEQVLLCASSQTSSIVECWSLRKEGLPVNNVFQQISPVVGDKQPMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLGLALAFHDGSVHIVHRLSLQSMAVFYNSAAPRSADEPAIKRPRASGPAVHFKAMQLSWTSLALVGIDNHGKLSMLRISPSMGHTLDVSLALRHLLFLLEYCMVTGYDWWDTLLHVQPAMVQSLVEKLHEEYTRQNAALQQVLSTRILAMKASLCKLSPCTVARVCDYHAKLFLVAVSSTLKSLLRPHFLNTPDKSPGDRLTEVCSKITDADIDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFVLYLLASLPNQGSPLRPGHSFLRDGPSLGLLRELMVVIRIWGLLKPGCLPVYTATSDTQDSMSLLFRLLTKLWICCESPALGSQHPRHGSVPGPVARTPGSHRLGPQCPARVLSERQPCACPRAPDGTSPGGVPSCQTPATRKAAWCQLVPGARASPVGSTSPRSPPHRPR
Length783
PositionTail
OrganismEnhydra lutris kenyoni
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Mustelidae> Lutrinae> Enhydra.
Aromaticity0.06
Grand average of hydropathy-0.000
Instability index46.16
Isoelectric point8.40
Molecular weight85763.15
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
catalytic activity	GO:0003824	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21008
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     346.98|      94|     189|     223|     343|       1
---------------------------------------------------------------------------
  225-  318 (164.11/86.80)	SPVQFYKVC.....VSVVS.EKCRIDTEILPSL....FMRCTTDLNRK.DKFPAITHLKFL.......ARDMSEQVLLCASSQTSSIVECW.SLRKEG..LPVNNV..FQQISPVVG
  420-  506 (92.13/42.82)	......KAM....qLSWTSlALVGIDNHGKLSM.....LRISPSMGHTlDVSLALRHLLFLleycmvtGYDWWDTLLHVQPAMVQSLVE...KLHEEY..TRQNAA..L........
  525-  610 (90.74/60.22)	SPCTVARVCdyhakLFLVA.V.....SSTLKSLlrphF......LNTP.DKSPG..............DR.LTE...VCSKITDADIDKVMiNLKTEEfvLDMNTLqaLQQLLQWVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.90|      24|      25|     728|     751|       2
---------------------------------------------------------------------------
  728-  751 (49.88/30.16)	RQPCACPRAPDG.TSPGGVPSCQTP
  754-  778 (41.02/23.33)	RKAAWCQLVPGArASPVGSTSPRSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     158.63|      49|     293|     366|     418|       3
---------------------------------------------------------------------------
  366-  418 (79.62/58.64)	PG.LGLALAFHD..GSVHIVHRLsLQSMAVFYNSAA.....PRSADEPAikrPRASGPAVH
  658-  714 (79.01/46.93)	PGcLPVYTATSDtqDSMSLLFRL.LTKLWICCESPAlgsqhPRHGSVPG...PVARTPGSH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21008 with Med16 domain of Kingdom Metazoa
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