<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21004

Description mediator of RNA polymerase II transcription subunit 25 isoform X4
SequenceMVPGSEGPARAGGLVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSSAYEFVTWLDGIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGYTTESLVQKIGEQGIHFSIVSPRKLPALRLLFEKAAPPALLEPLQPPADVSQDPRHMVLVRGLVLPVGGGSAPGPLQPKQPVPLPPAAPSGASLSAAPQQPLPPVPQQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPINPLQAAPGVGPPFSQAPAPPLPPGPPGAPKPPPASQPSLVSTVAPGPGLAPPAQPGAPSMAGSVAPGGVSGPSPAQLGAPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLVSGPRGHRPPLRSAGRILFPRPLPAPHLPPSLLLPSPLRTPARVSPVSPADHPGPFVPELEDGAVPLHQQGPGVPERPLPHHGQRLCRLRALPPHGPLRGARAHAALLVQEEDLHGPHPLRPERLRQRHPAGHHQPQASPAAEAGAAARDGGTAGTPWAGPHSGGPGETLTESAPAPPTTAPASGHCGGLRSLRTAPAPRCCPGPPRRPPRPSWSSPWPSPSWTHPPASEPWGQPPTAESPPQPTSAPDWGACTPSLPPPPPATGGSCTVAPTTPGSGATPAGAPPPAPTACPVLAHTASPESSTARVQPETSLRIKAQ
Length776
PositionUnknown
OrganismEnhydra lutris kenyoni
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Mustelidae> Lutrinae> Enhydra.
Aromaticity0.05
Grand average of hydropathy-0.320
Instability index68.89
Isoelectric point8.62
Molecular weight80134.23
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21004
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.99|      25|      26|     322|     347|       1
---------------------------------------------------------------------------
  323-  347 (56.95/10.45)	PAPPLPPGPPGAPKPP....PASQPSLVS
  654-  682 (40.04/ 6.64)	PAPRCCPGPPRRPPRPswssPWPSPSWTH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     662.12|     110|     111|     540|     649|       2
---------------------------------------------------------------------------
    7-  121 (64.83/ 9.39)	......................................................GPARagGLVADVVF....VI.....E...GTANL....GPY......FEGL..RKHYllPAIEY.FNG.................................GPPAETDFGG.....DYGG.TqyslvvfntvdcapesyvqchaptssayEFVT.WlDGiKFMGG..GGESCSLIAEGL.STA.............
  136-  256 (108.43/21.62)	GQthRVCLLiCNS.............................P.P.......YlLPAV..ESTTYSGYttesLV.....QkigEQGIHfsivSPR..KLP.ALRLlfEKAA..PPALLEP.L.................................QPPADVSQDP.....RHMVlV............................RGLV.L....PVGGGsaPGP.LQPKQPVPlPPA.AP....SGA..S
  261-  393 (92.18/17.06)	PQ........QPL.............................P.PvpqqyqvP.GNLS..AAQVAAQN....AVeaaknQ...KAGL.....GPRfsPIN.P..L..QAAP..GVGPPFSQApapplppgppgapkpppasqpslvstvapgpglAPPAQPGA............................................PsM.AG...SVA..PGGV...SGPSP.AQLgAPA...LGGQQS
  474-  539 (91.96/17.00)	.....ILFP.RPL.............................PaP.......H.LP.........PSL....LL...................PS..PLRtPARV..SPVS..PADHPGPFV..................................PELEDGA.........................................V..P.L.....HQQG..PG......VPER.PL...P..HH......
  540-  649 (206.17/49.02)	GQ..RLCRL.RAL.............................P.P.......H.GPLR..GARAHAAL....LV.....Q...EEDLH....GPH..PLR.PERL..RQRH..PAGHHQPQA.................................SPAAEAGAAA.....RDGG.T............................AGTP.W.AG.PHSGG..PGETLTESAPAP.PTT.APASGHCGGLRS
  650-  760 (98.55/18.85)	........L.RTApaprccpgpprrpprpswsspwpspswthP.P.......A.SEPW..G..........................Q....PPT..AES.P...........P....QPTS.................................AP..DWGACTpslppPPPA.T............................GGSC.T.VA.PTTPG..SGAT.PAGAPPPaPTA.CPVLAHTASPES
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21004 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GGSAPGPLQPKQPVPLPPAAPSGASLSAAPQQPLPPVPQQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPINPLQAAPGVGPPFSQAPAPPLPPGPPGAPKPPPASQPSLVSTVAPGPGLAPPAQPGAPSMAGSVAPGGVSGPSPAQLGAPALGGQQ
2) LPPSLLLPSPLRTPARVSPVSPADHPGPFVPELEDGAVPLHQQGPGVPERPLPHHGQRLCRLRALPPHGPLRGARAHAALLVQEEDLHGPHPLRPERLRQRHPAGHHQPQASPAAEAGAAARDGGTAGTPWAGPHSGGPGETLTESAPAPPTTAPASGHCGGLRSLRTAPAPRCCPGPPRRPPRPSWSSPWPSPSWTHPPASEPWGQPPTAESPPQPTSAPDWGACTPSLPPPPPATGGSCTVAPTTPGSGATPAGAPPPAPTACPVLAHTASPESSTARVQPETSLRIKAQ
232
485
392
776










Molecular Recognition Features






MoRF SequenceStartStop




1) TARVQPETSLRIKAQ
762
776