<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21003

Description mediator of RNA polymerase II transcription subunit 12
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAISETKVKKRHVIDPFMEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEVAIRQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVMSAQSTSTLPTTPAPQPPTSSTTSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDSERKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPYRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSSGSTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVNNWRDNQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAMLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLRKELGERQSDSLEKVLQLLPLPKPTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPPAKTEDYGMGPGRSGPYGVTVPPDLLHHTNPGSISHLSYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPPYPGVLPTTMTGVMGLEPSYKTSVYRQQQPAVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHAGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQAPMIGTMTPLGAQGVQAGVRSASILPEQQQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQILRVKP
Length2095
PositionKinase
OrganismEnhydra lutris kenyoni
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Mustelidae> Lutrinae> Enhydra.
Aromaticity0.07
Grand average of hydropathy-0.431
Instability index53.49
Isoelectric point6.65
Molecular weight233104.50
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21003
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.31|      15|      16|    2054|    2069|       1
---------------------------------------------------------------------------
 2054- 2068 (32.96/17.64)	QQQQQQQQQQQ....QQQQ
 2071- 2089 (27.36/ 9.28)	QQQQQQQQQQQyhirQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      71.96|      16|      17|    1793|    1808|       2
---------------------------------------------------------------------------
 1732- 1743 (20.58/ 9.02)	RPRPRA........YYLEPL
 1793- 1808 (32.31/19.81)	RSQPPAKT..ED..YGMGPG
 1809- 1828 (19.07/ 7.63)	RSGPYGVTvpPDllHHTNPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.67|      15|      18|    1996|    2010|       3
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 1996- 2010 (28.49/11.09)	QRPSGYVHQQAPTYG
 2017- 2031 (26.18/ 9.61)	QRFSHQTLQQAPMIG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     275.51|      55|      56|    1843|    1897|       4
---------------------------------------------------------------------------
 1744- 1787 (51.53/21.75)	........PLPPEDE..EPPAPTLLePEKKAP.EPPKtdkPGAAP...PST......EERKKKS
 1842- 1896 (101.26/50.62)	LYT..QNQPLPAGGPRVDPYRPVRL.PMQKLPTRPPY...PGVLPTTMTGV...MGLEPSYKTS
 1897- 1953 (81.64/39.23)	VYR..QQQPAVPQGQRLRQQLQAKI.QSQGMLGQSSV...HQMTPSSSYGLqtsQGYTP.YVSH
 1954- 1986 (41.07/15.68)	V..glQQHAGPA.GTMVPP....SY.SSQ..PYQSTH...PSTNPT..................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.38|      13|      16|     864|     879|       5
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  864-  876 (24.86/17.01)	MSYHLPLVQHVQF
  881-  893 (22.52/ 6.61)	MEYSLSISGLIDF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.06|      16|      20|    1047|    1063|       6
---------------------------------------------------------------------------
 1047- 1062 (29.88/15.24)	NP..ANRYSFVCNALMHV
 1068- 1085 (21.18/ 9.40)	DPdrVNDIAILCAELTGY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.38|      17|      18|     638|     655|       7
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  638-  655 (25.68/18.13)	FDDPAdDSERKEAEGSSS
  658-  674 (30.71/17.03)	LEDPG.LSESMDIDPSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.92|      24|      58|    1378|    1401|       8
---------------------------------------------------------------------------
 1378- 1401 (38.04/24.86)	SLLENIAKATIEVFQQSAETGSSS
 1439- 1462 (39.88/26.45)	SVQGHVLKAAGEELEKGQHLGSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.70|      14|      24|    1562|    1575|       9
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 1562- 1575 (24.50/14.82)	LLEIIISGTV..DMQS
 1586- 1601 (20.20/10.97)	MLSVLINGTLaaDMSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.31|      24|      24|     695|     718|      11
---------------------------------------------------------------------------
  695-  718 (42.89/20.41)	EGKGSPSPEKP.DVEKEVK.PPPKEK
  720-  745 (33.43/14.33)	EGTLGVLYDQPrHVQYATHfPIPQEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.58|      14|      17|    1665|    1681|      12
---------------------------------------------------------------------------
 1665- 1681 (16.87/17.70)	KIAGFDsIFkkEGLQVS
 1685- 1698 (28.71/15.95)	KISPWD.LF..EGLKPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      90.11|      18|      18|     347|     364|      13
---------------------------------------------------------------------------
  347-  364 (33.44/20.25)	FSDLLM.CPQHRPLVFGLS
  367-  383 (24.77/12.72)	LQTILLcCPS..ALVWHYS
  395-  412 (31.91/18.92)	LDHLPI.APSNLPMPEGNS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.05|      14|     664|     122|     135|      14
---------------------------------------------------------------------------
  122-  135 (24.94/14.69)	GTKPLTQLAKKVPI
  787-  800 (25.11/14.85)	GTAETDQLAPIVPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     130.55|      44|      60|    1188|    1237|      16
---------------------------------------------------------------------------
 1188- 1237 (61.80/64.95)	PCQSDGNKPtvGIRSSCDRHLLAASQNriVDgaVFA..VLKAVF...VLGDAELK
 1251- 1299 (68.75/49.62)	PEEEGGGGS..GGRRQGGRNISVETAS..LD..VYAkyVLRSICqqeWVGERCLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.70|      22|      24|     472|     495|      17
---------------------------------------------------------------------------
  467-  494 (30.25/24.88)	HsferSDFSNSLDSLCNriFGLGPSKDG
  495-  519 (34.45/21.35)	H.eisSDDDAVVSLLCE..WAVSCKRSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.51|      13|      15|    1330|    1343|      18
---------------------------------------------------------------------------
 1330- 1343 (19.39/17.67)	RLLDNEDgENPQRQ
 1347- 1359 (25.12/16.75)	RILQNLD.QWTMRQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21003 with Med12 domain of Kingdom Metazoa
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