<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20998

Description cyclin-dependent kinase 19 isoform X3
SequenceMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFQEDPLPTLDVFAGCQIPYPKREFLNEDEPEEKGDKNQQQQQNQHQQPTAAPQQAAAPPQAPPPQQNSTQTNGTAGGAGTGTGGAGPGLQHSQDSGLSQVPANKKPRLGPSGANSGGPVLPSDYQHSSSRLNYQSSVQGSSQSQSTLGYSSSSQQSAQYHPSHPGHRY
Length442
PositionKinase
OrganismEnhydra lutris kenyoni
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Mustelidae> Lutrinae> Enhydra.
Aromaticity0.08
Grand average of hydropathy-0.641
Instability index57.32
Isoelectric point8.79
Molecular weight49723.69
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
protein kinase activity	GO:0004672	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20998
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.01|      21|      37|     361|     396|       1
---------------------------------------------------------------------------
  337-  358 (36.53/13.48)	PPQQNStQTNGTA..........GGAGTGTGG
  361-  391 (32.48/39.07)	PGLQHS.QDSGLSqvpankkprlGPSGANSGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.44|      15|      41|      91|     105|       2
---------------------------------------------------------------------------
   91-  105 (26.77/19.16)	DLKPANILVMGEGPE
  129-  143 (28.67/21.04)	DLDPVVVTFWYRAPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     132.67|      39|      41|     254|     292|       3
---------------------------------------------------------------------------
  254-  292 (68.14/37.67)	KLLTMD.PTKRITSEQALQDPYFQEDPLPTLDVFAGCQIP
  297-  336 (64.53/35.29)	EFLNEDePEEKGDKNQQQQQNQHQQPTAAPQQAAAPPQAP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20998 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) YPKREFLNEDEPEEKGDKNQQQQQNQHQQPTAAPQQAAAPPQAPPPQQNSTQTNGTAGGAGTGTGGAGPGLQHSQDSGLSQVPANKKPRLGPSGANSGGPVLPSDYQHSSSRLNYQSSVQGSSQSQSTLGYSSSSQQSAQYHPSHPGHRY
293
442










Molecular Recognition Features






MoRF SequenceStartStop




1) AQYHPSHPGHRY
2) QSTLGYSSS
3) SRLNYQSSVQ
4) VPANKKPRLG
431
418
403
374
442
426
412
383