<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20995

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTAAANWVANGASLEDCHSNLFSLAELTGIKWRRYNFGGHGDCGPIISAPAQDDPILLSFIRCLQANLLCVWRRDVKPDCKELWIFWWGDEPNLVGVIHHELQVVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFVRPYEKDEKPVNKSEHLSCAFTFFLHGESNVCTSVEIAQHQPIYLINEEHIHMAQSSPAPFQVLVSPYGLNGTLTGQAYKMSDPATRKLIEEWQYFYPMVLKKKEELKEEEELGYNDDFPVAVEVIVGGVRMVYPSAFVLISQNDIPVPQSVAGAGGHITVGQQGLGSVKDPSNCGMPLTPPTSPEQAIIGDSGGTQSAVSHLGSQDGGMITMHSPKRSGKIPPKLHNHMVHRVWKECILNRTQSKRSQMSTPTLEEEPANNPATWDFVDPTQRVSCSCSRHKLLKRCAVGPNRPPAISQPGFSAGPSSSSSLPPPASKHKTTERPEKGDKLQKRPLIPFHHRPSVADEFCVEQDTPGQKLGLGGIDSSLEVSSSRKYDKQMAVPSRNTSKQMNLNPMDSPHSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYGNGLELQQLSTLDDRTVLVGQRLPLMAEVSETALYCGVRPSNPESSDKWWHSYRLPRIDDAEFRPPELQGDRCDAKMEVNSESTALQRLLAQPNKRFKIWQEKQPQMQPLHFLDPLPLAQQPGDSLGEVNDPYTFEDGDIKYIFTANKKCKQGTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTDVRQDNAAGRAGSSSLTQVTDLAPSLHDLDNIFDNSDDDELGAVSPALRSSKMPTVGAEDRPLGKDGRAAVPYPPTVADLQRMFPTPPSLEQHPAFSPVMNYKDGISSETVTALGMMESPMVSMVSTQLTEFKMEVEDGLGSPKPEEVKDFSYVHKAPTFQPFVGSSTFAPLKMLPSQCLLPLKIPDACLFRPSWAIPPKIEQLPMPPAAIFNRDGYNNVPSVGSLADPDYLNTPQMNTPVTLNSAAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQPIPEAHSLYVTLILSDSVMNIFKDRNFDSCCICACNMNIKGADVGLYIPDSSNEDQYRCTCGFSAIMNRRLGYNSGLFLEDELDIFGKNSDIGQAAERRLMMCQTTFLPQMEGARKSQEPPISLLLLLQNQHTQPFASLSFLDYISSNSRQTLPCVSWSYDRVQADNNDYWTECFNALEQGRQYVDNPTGGKVDEALVRSATVHSWPHSNVLDISMLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGTYGSEESPEPLPIPTLLVGCDKDFLTISPFSLPFWERLLLDPYGGHRDVAYIVVCPENEALLEGAKTFFRDLSAVYEMCRLGQHKPICKVLRDGIMRVGKTVAQKLTDELVSEWFNQPWSSEENDNHSRLKLYAQVCRHHLAPYLATLQLDSSLLIPPKYQSPPAAAQGQATPGNTGPLASNSGSAAPSAGSAFNPTSNSTSGNPAASSSASGSSVPPVSSSAPAAVVNQASTTSSSGFSASVGGQNPSTGASSADRTQGNMGCGGDTEPGQSSSQSSQDGQESVTERERIGIPTEPDSADSQAYPPAVVIYMVDPFTYTADEDSTSGNFWLLSLMRCYTEMLDNLPEHMRNSFILQIVPCQYMLQTMKDEQVFYIQYLKSMAFSVYCQCRRPLPTQIHIKSLTGFGPAASIEMTLKNPERPSPIQLYSPPFILAPIKDKQTELGETFGEASQKYNVLFVGYCLSHDQRWLLASCTDLHGELLETCIVNIALPNRSRRSKVSARKIGLQKLWEWCIGIVQMTSLPWRVVIGRLGRLGHGELKDWSILLGECSLQTISKRLKDVCRMCGISAADSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNMQSSQLNTPQDASCTHILVFPTSSTIQVAPANYPNEDGFSPNNDDMFVDLPFPDDMDNDIGILMTGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQAQNQCPLFLKASLHHHISVAQTDELLPARNSQRVPHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRTSCLPVHFVVLTQLYNAIMNIL
Length2210
PositionMiddle
OrganismEnhydra lutris kenyoni
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Mustelidae> Lutrinae> Enhydra.
Aromaticity0.07
Grand average of hydropathy-0.385
Instability index57.69
Isoelectric point5.67
Molecular weight242608.68
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20995
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     127.81|      24|      26|    1621|    1644|       1
---------------------------------------------------------------------------
 1560- 1579 (28.76/10.80)	.SAFNPTSNSTS......G........NPAASSSA
 1597- 1620 (25.54/ 8.73)	NQASTT...SSS......GfsasvGGQNP..STGA
 1621- 1644 (45.25/21.42)	SSADRTQGNMGC......G.....GDTEPGQSSSQ
 1645- 1671 (28.27/10.48)	SSQD...GQESVtereriG.....IPTEPDSADSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     121.62|      28|      28|    1033|    1060|       2
---------------------------------------------------------------------------
 1002- 1032 (35.60/13.90)	SVGSLADPdylNTPQMNTPVTLNS.AAPASNS
 1033- 1060 (49.26/22.38)	GAGVLPSP...ATPRFSVPTPRTP.RTPRTPR
 1061- 1089 (36.77/14.63)	GGGTASGQ...GSVKYDSTDQGSPaSTPSTTR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     169.23|      54|     626|    1449|    1509|       3
---------------------------------------------------------------------------
 1449- 1509 (76.79/71.72)	LGQHKPicKVLRDGIMRVGKTVAQKLTDELvSEWFnqpWSS.EENDNHSRLKLYAQVcRHHL
 2082- 2136 (92.44/58.27)	LSREAP..EELKQQPLALGYFVSTAKAENL.PQWF...WSScPQAQNQCPLFLKASL.HHHI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.78|      25|      28|    1126|    1150|       4
---------------------------------------------------------------------------
 1126- 1150 (51.15/30.47)	NFDSC.CICACN..MNIK.GADVGLYIPD
 1153- 1181 (36.64/19.75)	NEDQYrCTCGFSaiMNRRlGYNSGLFLED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.56|      21|      22|     951|     972|       5
---------------------------------------------------------------------------
  949-  970 (33.76/19.74)	FAPLKMLPSQcLLPLKIPDACL
  971-  991 (39.80/18.47)	FRPSWAIPPK.IEQLPMPPAAI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.42|      18|      22|    1697|    1716|       6
---------------------------------------------------------------------------
 1697- 1716 (30.77/27.55)	NFWLLSLMRC.YteMLDNLPE
 1720- 1738 (29.64/18.96)	NSFILQIVPCqY..MLQTMKD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.89|      18|      22|    2000|    2017|       7
---------------------------------------------------------------------------
 2000- 2017 (32.43/20.78)	PTSSTIQVA...PANYPNEDG
 2020- 2040 (29.46/18.08)	PNNDDMFVDlpfPDDMDNDIG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.81|      17|      22|    1375|    1391|       8
---------------------------------------------------------------------------
 1375- 1391 (33.62/20.80)	SPEPLPI.PTLLV...GCDKD
 1396- 1416 (23.20/11.53)	SPFSLPFwERLLLdpyGGHRD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.69|      12|      23|     542|     553|       9
---------------------------------------------------------------------------
  542-  553 (24.80/12.93)	NPMDSPHSPISP
  568-  579 (22.89/11.19)	ESLDPPSVPVNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     200.08|      61|     111|     321|     393|      10
---------------------------------------------------------------------------
  327-  393 (101.28/56.05)	PPTSPEQaiiGDSGGTQSAvSHLGSQDGGMITMHSPKRSGKIP..PKLHNHmvHR..VWKE.CILNRTQSKR
  441-  506 (98.80/44.19)	PPAISQP...GFSAGPSSS.SSLPPPASKHKTTERPEKGDKLQkrPLIPFH..HRpsVADEfCVEQDTPGQK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.55|      11|      22|    1231|    1241|      11
---------------------------------------------------------------------------
 1231- 1241 (20.74/ 9.54)	QHTQPFASLSF
 1250- 1260 (22.81/11.24)	RQTLPCVSWSY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.38|      19|      22|     817|     836|      12
---------------------------------------------------------------------------
  817-  836 (27.94/22.05)	DDDELGAVSPALRSSKmPTV
  839-  857 (35.45/22.83)	EDRPLGKDGRAAVPYP.PTV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.52|      20|      23|      65|      84|      13
---------------------------------------------------------------------------
   65-   84 (38.38/26.69)	QANLLCVWRRDVKPDCKELW
   91-  110 (35.14/23.74)	EPNLVGVIHHELQVVEEGLW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.85|      25|      27|    1858|    1884|      14
---------------------------------------------------------------------------
 1858- 1884 (40.94/30.19)	I...ALPNRSRRSKVSarKIGLQKLWEWCI
 1887- 1914 (39.91/23.13)	VqmtSLPWRVVIGRLG..RLGHGELKDWSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      57.23|      10|      21|    1525|    1534|      17
---------------------------------------------------------------------------
 1525- 1534 (21.01/ 9.89)	PPKYQSPPAA
 1546- 1555 (16.93/ 6.14)	PLASNSGSAA
 1585- 1594 (19.29/ 8.31)	PPVSSSAPAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.79|      13|      22|    1952|    1964|      19
---------------------------------------------------------------------------
 1952- 1964 (24.21/14.88)	AMEPQGSFVVMPD
 1977- 1989 (22.58/13.28)	ALNMQSSQLNTPQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20995 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) APSLHDLDNIFDNSDDDELGAVSPALRSSKMPTVGAEDRPLGKDGRAAVP
2) CAVGPNRPPAISQPGFSAGPSSSSSLPPPASKHKTTERPEKGDKLQKRPLIPF
3) ECILNRTQSKRSQMSTPTLEEEPANNPATWDFV
4) GILMTGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPE
5) GTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTDVRQDNAAGRAGSSSLTQVTD
6) HRPSVADEFCVEQDTPGQKLGLGGIDSSLEVSSSRKYDKQMAVPSRNTSKQMNLNPMDSPHSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYG
7) ITVGQQGLGSVKDPSNCGMPLTPPTSPEQAIIGDSGGTQSAVSHLGSQDGGMITMHSPKRSGKIPPKLH
8) KYQSPPAAAQGQATPGNTGPLASNSGSAAPSAGSAFNPTSNSTSGNPAASSSASGSSVPPVSSSAPAAVVNQASTTSSSGFSASVGGQNPSTGASSADRTQGNMGCGGDTEPGQSSSQSSQDGQESVTERERIGIPTEPDSA
9) SVGSLADPDYLNTPQMNTPVTLNSAAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQ
803
434
383
2040
735
488
305
1527
1002
852
486
415
2088
801
583
373
1668
1100










Molecular Recognition Features






MoRF SequenceStartStop




NANANA