<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20994

Description cyclin-dependent kinase 19 isoform X2
SequenceMDYDFKAKLAAERERVEDLFEYEGCKVGRGTYGHVYKARRKDGKDEKEYALKQIEGTGISMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFQEDPLPTLDVFAGCQIPYPKREFLNEDEPEEKGDKNQQQQQNQHQQPTAAPQQAAAPPQAPPPQQNSTQTNGTAGGAGTGTGGAGPGLQHSQDSGLSQVPANKKPRLGPSGANSGGPVLPSDYQHSSSRLNYQSSVQGSSQSQSTLGYSSSSQQSAQYHPSHPGHRY
Length458
PositionKinase
OrganismEnhydra lutris kenyoni
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Mustelidae> Lutrinae> Enhydra.
Aromaticity0.08
Grand average of hydropathy-0.783
Instability index54.81
Isoelectric point8.55
Molecular weight51698.62
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein serine/threonine kinase activity	GO:0004674	IEA:UniProtKB-KW

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20994
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.93|      17|      21|     320|     336|       1
---------------------------------------------------------------------------
  320-  336 (31.51/17.38)	PEEKGDKNQ..QQQQNQHQ
  342-  360 (27.42/14.18)	PQQAAAPPQapPPQQNSTQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     303.18|      95|     151|      12|     118|       2
---------------------------------------------------------------------------
   12-  118 (144.38/117.41)	ERERVE.DLFEYeGCKVGR.GTYGHVYKARRKDGKDEKEYALKQIEG..TGISMSACREIALLRelKHPNVIALQKVFlshsdRKVwllfDYAEHDLWHIIKFHRASKANK
  165-  263 (158.80/97.86)	ERGRVKiDIWAI.GCIFAElLTSEPIFHCRQEDIKTSNPFHHDQLDRifSVMGFPADKDWEDIR..KMPEYPTLQKDF.....RRT....TYANSSLIKYMEKHKVKPDSK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.76|      17|      32|     366|     382|       3
---------------------------------------------------------------------------
  366-  382 (33.75/20.05)	GGAGTGTGG.AGPG.LQHS
  399-  417 (25.02/13.06)	GPSGANSGGpVLPSdYQHS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.15|      14|      17|     419|     432|       4
---------------------------------------------------------------------------
  419-  432 (25.83/17.36)	SRLNYQSSVQGSSQ
  435-  448 (25.32/16.87)	STLGYSSSSQQSAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.52|      16|      17|     275|     290|       5
---------------------------------------------------------------------------
  275-  290 (28.65/19.88)	DPTKRITSEQALQDPY
  294-  309 (30.88/22.00)	DPLPTLDVFAGCQIPY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20994 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) YPKREFLNEDEPEEKGDKNQQQQQNQHQQPTAAPQQAAAPPQAPPPQQNSTQTNGTAGGAGTGTGGAGPGLQHSQDSGLSQVPANKKPRLGPSGANSGGPVLPSDYQHSSSRLNYQSSVQGSSQSQSTLGYSSSSQQSAQYHPSHPGHRY
309
458










Molecular Recognition Features






MoRF SequenceStartStop




1) AQYHPSHPGHRY
2) QSTLGYSS
3) RLNYQSSV
4) VPANKKPRLG
447
434
420
390
458
441
427
399