<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20987

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSDPATRKLIEEWQYFYPMVLKKKEELKEEEELGYNDDFPVAVEVIVGGVRMVYPSAFVLISQNDIPVPQSVAGAGGHITVGQQGLGSVKDPSNCGMPLTPPTSPEQAIIGDSGGTQSAVSHLGSQDGGMITMHSPKRSGKIPPKLHNHMVHRVWKECILNRTQSKRSQMSTPTLEEEPANNPATWDFVDPTQRVSCSCSRHKLLKRCAVGPNRPPAISQPGFSAGPSSSSSLPPPASKHKTTERPEKGDKLQKRPLIPFHHRPSVADEFCVEQDTPGQKLGLGGIDSSLEVSSSRKYDKQMAVPSRNTSKQMNLNPMDSPHSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYGNGLELQQLSTLDDRTVLVGQRLPLMAEVSETALYCGVRPSNPESSDKWWHSYRLPRIDDAEFRPPELQGDRCDAKMEVNSESTALQRLLAQPNKRFKIWQEKQPQMQPLHFLDPLPLAQQPGDSLGEVNDPYTFEDGDIKYIFTANKKCKQGTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTDVRQDNAAGRAGSSSLTQVTDLAPSLHDLDNIFDNSDDDELGAVSPALRSSKMPTVGAEDRPLGKDGRAAVPYPPIADLQRMFPTPPSLEQHPAFSPVMNYKDGISSETVTALGMMESPMVSMVSTQLTEFKMEVEDGLGSPKPEEVKDFSYVHKAPTFQPFVGSSTFAPLKMLPSQCLLPLKIPDACLFRPSWAIPPKIEQLPMPPAAIFNRDGYNNVPSVGSLADPDYLNTPQMNTPVTLNSAAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQPIPEAHSLYVTLILSDSVMNIFKDRNFDSCCICACNMNIKGADVGLYIPDSSNEDQYRCTCGFSAIMNRRLGYNSGLFLEDELDIFGKNSDIGQAAERRLMMCQTTFLPQMEGARKSQEPPISLLLLLQNQHTQPFASLSFLDYISSNSRQTLPCVSWSYDRVQADNNDYWTECFNALEQGRQYVDNPTGGKVDEALVRSATVHSWPHSNVLDISMLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGTYGSEESPEPLPIPTLLVGCDKDFLTISPFSLPFWERLLLDPYGGHRDVAYIVVCPENEALLEGAKTFFRDLSAVYEMCRLGQHKPICKVLRDGIMRVGKTVAQKLTDELVSEWFNQPWSSEENDNHSRLKLYAQVCRHHLAPYLATLQLDSSLLIPPKYQSPPAAAQGQATPGNTGPLASNSGSAAPSAGSAFNPTSNSTSGNPAASSSASGSSVPPVSSSAPAAVVNQASTTSSSGFSASVGGQNPSTGASSADRTQGNMGCGGDTEPGQSSSQSSQDGQESVTERERIGIPTEPDSADSQAYPPAVVIYMVDPFTYTADEDSTSGNFWLLSLMRCYTEMLDNLPEHMRNSFILQIVPCQYMLQTMKDEQVFYIQYLKSMAFSVYCQCRRPLPTQIHIKSLTGFGPAASIEMTLKNPERPSPIQLYSPPFILAPIKDKQTELGETFGEASQKYNVLFVGYCLSHDQRWLLASCTDLHGELLETCIVNIALPNRSRRSKVSARKIGLQKLWEWCIGIVQMTSLPWRVVIGRLGRLGHGELKDWSILLGECSLQTISKRLKDVCRMCGISAADSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNMQSSQLNTPQDASCTHILVFPTSSTIQVAPANYPNEDGFSPNNDDMFVDLPFPDDMDNDIGILMTGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQAQNQCPLFLKASLHHHISVAQTDELLPARNSQRVPHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRTSCLPVHFVVLTQLYNAIMNIL
Length1983
PositionMiddle
OrganismEnhydra lutris kenyoni
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Mustelidae> Lutrinae> Enhydra.
Aromaticity0.07
Grand average of hydropathy-0.413
Instability index59.16
Isoelectric point5.65
Molecular weight216796.46
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20987
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|    1022.72|     205|     625|      83|     291|       1
---------------------------------------------------------------------------
   79-  285 (341.66/149.89)	IT......................vgQQGLGSVKDPSNC..GMPLTPPTSPEQAIIGDSGGTQSAVSHLGSQDG.GMITMHSP.....KRSGKIPP.KLHNHMVHRVWKECILNRTQSKR....SQMSTPTLEEEP.ANNPATWDF...VDP.............T..QRVSCSCSRHKL.LKRCAVG...................PNRPPAISQPGFSAGPSSSSSLPPPASKHKTTERPEKGDKL..QKRP.LIP.FHHRPSVADEFCV...E...QDTPGQKLGLGG
  286-  480 (225.12/100.02)	IDsslevsssrkydkqmavpsrntskQMNLNPMDSPHSP..ISPLPPTLSP....................QPR.GQETESLD.....PPSVPVNP.ALYGNGLELQQLSTLDDRTVLVG....QRL..PLMAE...VSETALYCG...VRP.............S..NPESSDKWWHSYrLPRIDDA...................EFRPPELQGDRCDAKMEVNS...ESTALQRLLAQPNKRFKIwqEKQPqMQP.LH....FLDPLPL...A...QQ.PGD......
  482-  677 (212.91/89.71)	.............................LGEVNDPYTFedGDIKYIFTANKKC...KQGTEKDSLKKNKSEDGfGTKDVTTP.....GHSTPVPDgKNAMSIFSSATKTDV..RQDNAA....GRAGSSSLTQVT.DLAPSLHDLdniFDN.............SddDELGAVSPALRS.SKMPTVG..................aEDRP..LGKDGRAAVP.....YPPIADLQRMFPTP...PSL..EQHPaFSPvMNYKDGISSETVT...AlgmMESPMVSM....
  690-  921 (243.04/103.62)	..........................EDGLGSPKPEEVK..DFSYVHKAPTFQPFVGSS..TFAPLKMLPSQ...CLLPLKIPdaclfRPSWAIPP.KIEQLPMP...PAAIFNRDGYNNvpsvGSLADPDYLNTPqMNTPVTLNS...AAPasnsgagvlpspaT..PRFSVPTPRTPR.TPRTPRGggtasgqgsvkydstdqgsPASTPSTTRPLNSVEPATMQPIPEAHSLYVTL.......IL..SDSV.MNI.FKDRN..FDSCCIcacN...MNIKGADVGLYI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      92.69|      21|      24|    1332|    1354|       2
---------------------------------------------------------------------------
 1332- 1352 (37.35/15.35)	G..SAFNPTSNSTSG...NPAASSSA
 1354- 1377 (27.89/ 8.32)	G..SSVPPVSSSAPAavvNQASTTSS
 1392- 1417 (27.45/ 8.11)	GasSADRTQGNMGCGgdtEPGQSSSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.69|      27|      29|    1627|    1655|       3
---------------------------------------------------------------------------
 1627- 1655 (44.42/32.83)	C..IVNI.ALPNRSRRSKVSarKIGLQKLWEW
 1656- 1685 (42.27/24.91)	CigIVQMtSLPWRVVIGRLG..RLGHGELKDW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.08|      23|      26|    1513|    1538|       5
---------------------------------------------------------------------------
 1516- 1538 (45.78/32.35)	YIQYLKSM..AFSVYCQCR...RPLPTQ
 1540- 1567 (28.29/10.12)	HIKSLTGFgpAASIEMTLKnpeRPSPIQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.07|      18|      29|    1792|    1814|       6
---------------------------------------------------------------------------
 1792- 1814 (24.82/22.27)	SPNNDdmfvDLPFPDDmDNDIGI
 1823- 1840 (34.25/15.00)	SPNSS....PVPSPGS.PSGIGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.22|      22|      28|    1847|    1868|       8
---------------------------------------------------------------------------
 1847- 1868 (36.81/19.47)	SRSQGERL...LSREAPEELKQQPL
 1875- 1899 (36.41/19.17)	STAKAENLpqwFWSSCPQAQNQCPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.15|      12|      28|     941|     952|       9
---------------------------------------------------------------------------
  941-  952 (21.96/14.83)	NRRLGYNSGLFL
  970-  981 (23.19/16.15)	ERRLMMCQTTFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.86|      19|      21|    1470|    1489|      10
---------------------------------------------------------------------------
 1470- 1489 (31.05/25.26)	NFWLLSLMRCyTEMLDNLPE
 1493- 1511 (34.81/22.43)	NSFILQIVPC.QYMLQTMKD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20987 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) CAVGPNRPPAISQPGFSAGPSSSSSLPPPASKHKTTERPEKGDKLQKRPLIPF
2) ECILNRTQSKRSQMSTPTLEEEPANNPATWDFV
3) GILMTGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPE
4) GTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTDVRQDNAAGRAGSSSLTQVTD
5) HRPSVADEFCVEQDTPGQKLGLGGIDSSLEVSSSRKYDKQMAVPSRNTSKQMNLNPMDSPHSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYG
6) ITVGQQGLGSVKDPSNCGMPLTPPTSPEQAIIGDSGGTQSAVSHLGSQDGGMITMHSPKRSGKIPPKLH
7) KYQSPPAAAQGQATPGNTGPLASNSGSAAPSAGSAFNPTSNSTSGNPAASSSASGSSVPPVSSSAPAAVVNQASTTSSSGFSASVGGQNPSTGASSADRTQGNMGCGGDTEPGQSSSQSSQDGQESVTERERIGIPTEPDSA
8) PSLHDLDNIFDNSDDDELGAVSPALRSSKMPTVGAEDRPLGKDGRAAV
9) SVGSLADPDYLNTPQMNTPVTLNSAAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQ
208
157
1813
509
262
79
1300
578
775
260
189
1861
575
357
147
1441
625
873










Molecular Recognition Features






MoRF SequenceStartStop




1) WWHSYRLPRI
405
414