<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20983

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSSSFVPNGASLEDCHCNLFCLADLTGIKWKRYVWQGPTSAPILFPVTEEDPILSSFSRCLKADVLGVWRRDQRPGRRELWIFWWGEDPSFADLIHHDLSEEEDGVWENGLSYECRTLLFKAVHNLLERCLMNRNFVRIGKWFVKPYEKDEKPINKSEHLSCSFTFFLHGDSNVCTSVEINQHQPVYLLSEEHITLAQQSNSPFQVILSPFGLNGTLTGQAFKMSDSATKKLIGEWKQFYPISSCLKEMSEEKQEDMDWEDDSLAAVEVLVAGVRMIYPACFVLVPQSDIPTPSSVGSSHCSASCLGVHQVPASTRDPAISSVTLTPPTSPEEVQTVDPQSAQKWVKFSSVSDGFNSDSTNHHGGKIPRKLANHVVDRVWQECNMNRAQNKRKYSASSGGLSEEEIPDKVASWDFVEATQRTNCSCLRHKNLKPRNPGQQGQALSLSQQQQVLPKHKTNEKQEKSEKPQKRPLTPFHHRVSVSDDVGMDTDSASQRLVISAPDSQVRFSNIRTNDVAKTPQMHGTEMANSPQPPPLSPHPCDVVDEGVTKTPSTPQSQHFYQMPTPDPLVPSKPMEDRIDSLSQSFPAQFQEAVEPTVYVGTAVNLEEDEANIAWKYYKVPKKKDVEFLPPQLPSDKFKDDPVGPFGQESVTSVTELMVQCKKPLKVSDELVQQYQIKNQYLSAIASDAEQESKIDPYAFVEGDEEFLFPDKKERQNSEREAVKKHKVKDGPSSVTVLSHEEDAMSLFSPSIKQDAPRPTSHARPPSTSLIYDSDLAVSYTDLDNLFNSDEDELTPGSKKSANGTDDKSSSKESKTGNLDPLSCISTADLHKMYPTPPSLEQHIMGFSPMNMSNKEYGSMDITPGGTVLEGNSSSIGTQFKIEVDEGFCSPKPSEIKDFSYVYKPENCQVLVGCSMFAPLKSLPSQCLPPIKLPEECIYRQSWTVGKLELLPSGPAVPFIKEGDGSTIDQEYGPAYTPQTHTSFGMPPSSAPPSNSGAGILPSPSTPRFPTPRTPRTPRTPRAGGPASAQGSVKYENSDLYSPASTPSTCRPLNSVEPATVPSIPEAHSLYVNLILSESVMNLFKDCNFDSCCICVCNMNIKGADVGVYIPDPMQEAQYRCTCGFSAVMNRKFGNNSGLFLEDELDIIGRNTECGKEAEKRFEALRATSAEHVNGGLKESEKFPDELILLLQDQCTNLFSPFGAADQDPFPRIGVISNWVRVEERDCCNDCYLALEHGRQFMDNMSGGKVDEALVKSSCLHPWSKRNDVSMQCSQDILRMLLSLQPVLQDAIQKKRTVRPWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLLGYDYDFLVLSPFALPYWERLMLEPYGSQRDIAYVVLCPENEALLNGAKSFFRDLTAIYESCRLGQHRPISRLLTDGIMRVGSTASKKLSEKLVAEWFSQAADGNNEAFSKLKLYAQVCRYDLGPYLASQPLDSSLLSQPNLVAPTSQSLITPSQMTSTGNANTPSATLASAASSTMTMTSGVTMSSSVATANSTLTTTSTSSSSSSNLNSGVSSNKLPSFPPFGSINSSATGSMSTQASTVQNGQLGGQQSSALQTAGISGESSSLPTQPHPDVSESTMDRDKVGIPTDGDSHAVTYPPAIVVYIIDPFTYENKDESTNSSNVWTLGLLRCFLEMVQTLPPHIKNTVSVQIVPCQYLLQPVKHEDRQIYTQHLKSLAFSAFTQCRRPLPTSTNVKTLTGFGPGLAMETALKSPDRPECIRLYTPPFILAPVKDKQTELGETFGEAGQKYNVLFVGYCLSHDQRWILASCTDLYGELLETCIINIDVPNRARRKKGSARRFGLQKLWEWCLGLVQMSSLPWRVVIGRLGRIGHGELKDWSSLLSRRNLQSLSKRLKDMCRMCGISAADSPSILSACLVAMEPQGSFVIMPDSVSTGSVFGRSTTLNMQTSQLSTPQDTSCTHILVFPTSASVQVASATYTTENLDLAFNPNNDGADGMGIFDLLDTGDDLDPDIINILPASPTGSPVHSPGSHYPHGGDAGKGQGTDRLLSTESHDEVTNILQQPLALGYFVSTAKAGPLPDWFWSACPQAQYQCPLFLKASLHLHVPSVQSDELLHSKHSHPLDSNQTSDVLRFVLEQYNALSWLTCDPAIQDRRSCLPIHFVVLNQLYNFIMNML
Length2173
PositionMiddle
OrganismEnhydra lutris kenyoni
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Mustelidae> Lutrinae> Enhydra.
Aromaticity0.08
Grand average of hydropathy-0.399
Instability index52.66
Isoelectric point5.44
Molecular weight239479.42
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20983
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     243.41|      62|      67|     924|     988|       1
---------------------------------------------------------------------------
  534-  566 (48.89/22.08)	PPLS......PHP............................CDVVDEG....VTktP.STPQSQHFYQMPtP
  924-  988 (108.07/68.58)	PSQCLPPIkLPEECIYRqsWTVGKLELLPSGPAVPFIKEGDGSTIDQE....YG..PAYTPQTHTSFGMP.P
  993- 1049 (86.45/45.87)	PSNSGAGI.LPSPSTPR..FPTPRTPRTPRTPRAGGPASAQGS.VKYEnsdlYS..PASTPST.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     233.34|      73|     532|    1224|    1309|       2
---------------------------------------------------------------------------
  690-  765 (112.92/61.81)	EQESKIDPYAFVEGDEEFLfpDKKERQNSEREAVKKHKVKDGPSSVTV.LSHEEDAMSL...FSPsIKQDAPRPTSHARP
 1224- 1300 (120.42/94.05)	ERDCCNDCYLALEHGRQFM..DNMSGGKVDEALVKSSCLHPWSKRNDVsMQCSQDILRMllsLQP.VLQDAIQKKRTVRP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     236.56|      66|      67|    1463|    1528|       3
---------------------------------------------------------------------------
 1463- 1528 (108.17/64.00)	LASQPLDSSLLSQPNLVAPTSQSLITPSQMTSTGNAN.TPSATLASAASSTMTMTSGVTMSSSVATA
 1532- 1594 (95.64/55.56)	LTTTSTSSS..SSSNLNSGVSSNKL.PS.FPPFGSINsSATGSMSTQASTVQNGQLGGQQSSALQTA
 1876- 1907 (32.75/13.27)	.......SSLLSRRNL.QSLSKRLKDMCRMCGISAAD.SPS..........................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.39|      25|     530|    1063|    1114|       5
---------------------------------------------------------------------------
 1090- 1114 (50.44/75.40)	DSCCICVCN....MNIK.GADVGVYIPDPM
 1116- 1145 (36.94/ 9.56)	EAQYRCTCGfsavMNRKfGNNSGLFLEDEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.10|      27|      43|    1986|    2014|       6
---------------------------------------------------------------------------
 1986- 2014 (40.47/33.57)	PN.NDGADGMGIFDLLDTgDDLDpDIINIL
 2031- 2058 (44.63/26.32)	PHgGDAGKGQGTDRLLST.ESHD.EVTNIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     281.39|      88|     226|     567|     669|       7
---------------------------------------------------------------------------
  318-  353 (33.23/11.80)	.........................................................PAISSVTLTPPTSPEEVQTVDPQSAQKWVKFSSV.............SD
  364-  442 (112.69/58.00)	GGKIPRKLANHVVDRVWQE..CNMNRAQNKRKYSASSGGLSEEEIpdKVAsWDFVEATQRTNCSCLRHK....NLKPRNPGQQGQ.....................
  567-  669 (135.47/101.84)	DPLVPSKPMEDRIDSLSQSfpAQFQEAVEPTVYVGTAVNLEEDEA..NIA.WKYYKVPKKKDVEFLPPQLPSDKFKDDPVGPFGQESVTSVtelmvqckkplkvSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.94|      23|      41|    1755|    1778|       8
---------------------------------------------------------------------------
 1755- 1778 (38.36/28.06)	CIRlYTPPFILAPVKDKQTELGET
 1794- 1816 (43.59/27.50)	CLS.HDQRWILASCTDLYGELLET
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.05|      15|      20|    1312|    1331|      10
---------------------------------------------------------------------------
 1306- 1328 (15.07/20.88)	PLTwqqFhkMAGrgsYGTDE...SPE
 1329- 1349 (21.98/10.13)	PLPiptF..LLG...YDYDFlvlSPF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.81|      15|      26|    1595|    1611|      11
---------------------------------------------------------------------------
 1595- 1611 (19.17/17.68)	GI..SGESSSLpTQPhPDV
 1622- 1638 (24.63/11.06)	GIptDGDSHAV.TYP.PAI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     166.13|      51|     263|     180|     233|      14
---------------------------------------------------------------------------
  180-  233 (82.63/62.14)	INQHQPVYllsEEHITLAQQ..SNSPFQVILSPFGLNGTLTGQAFKMSDSATKKLI
  446-  498 (83.51/55.24)	LSQQQQVL...PKHKTNEKQekSEKPQKRPLTPFHHRVSVSDDVGMDTDSASQRLV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20983 with Med13 domain of Kingdom Metazoa
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