<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20982

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAVMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYASPSDLLDDKTTSPIILHENNVPRSLGMNASVTIEGTSAMYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYVPLYELITQFELSKDPDPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSISFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEICPGSNKTKKKKSSRLPPDKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPLPHPQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDCPPIGTPVRDSSSSGHSQSALFDPDVFQTNNNENPYTDPADLIADAAGSPSSDSPTNHFFPDGVDFNPDLLNSQSQGGFGEEYFDESSQSGDNDDFKGFASQALNTLGVPMLGGDNGETKFKGNSQADTVDFSIISVAGKALGPADLMEHHSGSQSPLLTTGDLGKEKTQKRVKEGNGTSNSSLSGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSGSKSHHSHSSSSSSSSSASNSGKMKSSKSEGSSSSKLSSSVYSSQGSSGSSQSKNSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPGGSEKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTSSSTGMKSSSGLGSSGSLSQKTPPSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPMDGQMGVSTNSSSHPMSSKHNMSGGEFQSKREKSDKEKSKVSTSGGSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMTSSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDKDRDRDRDKDRDKKKSHSIKPESWSKSPISSDQSLSMTSNTILSTDRPSRLSPDFMIGEEDDDLMDVALIGN
Length1583
PositionMiddle
OrganismEnhydra lutris kenyoni
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Mustelidae> Lutrinae> Enhydra.
Aromaticity0.04
Grand average of hydropathy-0.688
Instability index54.28
Isoelectric point8.88
Molecular weight168746.49
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20982
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     251.03|      49|      50|     965|    1013|       1
---------------------------------------------------------------------------
  965- 1013 (78.19/22.57)	KEKTQKRVK...EGNGTS..NSSLSGPGLDSKPGKRS.RTPSNDGK..SKDKP.......PKRK
 1014- 1064 (37.89/ 6.53)	........KadtEGKSPS..HSSSNRPFTPPTSTGGS.KSPGSSGR..SQTPPgvatppiPKIT
 1065- 1114 (42.00/ 8.16)	IQIPKGTVM...VGKPSS..HSQYTSSGSVSSSGSKShHSHSSSSS..SSSSA.......SNSG
 1115- 1162 (46.66/10.02)	KMKSSK.......SEGSS..SSKLSSSVYSSQGSSGS.SQSKNSSQ..SGGKP....gssPITK
 1167- 1217 (46.30/ 9.87)	SGSSSTKMK..pQGKPSSlmNPSLSKPNI..SP.SHS.RPPGGSEKlaSPMKP.......VPGT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     355.37|      49|      50|    1383|    1432|       2
---------------------------------------------------------------------------
 1248- 1287 (60.55/22.04)	SSGLGSSGS...LSQK...TPPS.......SNSCTAS...S......SSF.SSSGSS...........MSSSQN
 1288- 1336 (37.73/10.53)	.....QHGSSK..........GK.......SPSRNKKPSLTavidklKHGvVTSGPGgedpMD..GQ.MGVSTN
 1344- 1379 (52.86/18.17)	SKHNMSGGEFQ...SK...RE.K.......SDKEKSKV...........S.TSGGS............VDSSKK
 1383- 1432 (78.77/34.27)	SKNVGSTGVAKiIISK...HDGG.......SPSIKAKVTLQ......KPG.ESSGEG....LR..PQ.MTSSKN
 1436- 1468 (43.87/13.63)	PLISGST.......PK...HERG.......SPS..................HSKSPA....YT..PQnLDSESE
 1469- 1499 (39.74/11.55)	S...GSS.....IAEK...SYQN.......SPS....................SDDG....IRplPE.YSTEKH
 1500- 1550 (41.84/12.61)	KKHKKEKKKVK...DKdrdRDRDkdrdkkkSHSIKPE.SWS......KSP.ISSDQS....L....S.MTS...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     213.00|      49|      50|     324|     373|       3
---------------------------------------------------------------------------
  298-  322 (26.92/10.63)	..................DLPACFFL.KFPQPIPVSRA.................F...VQKL...Q..
  324-  373 (88.62/59.77)	CTGIPLFETqPTYVPLY.ELITQFELSKDPDPIPLNHNM...............RF...YAALPGQQHC
  383-  424 (39.32/19.54)	..........PDGRSLQgTLVSKITF.QHPGRVPLILNL..............iRHqvaYNTLIGS..C
  434-  489 (58.14/33.37)	SPGLLQFEV....CPLS.E..SRFSISFQH...PVNDSLvcvvmdvqdsthvscKL...YKGLSDALIC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     404.86|     110|     117|     535|     651|       4
---------------------------------------------------------------------------
  564-  676 (185.97/74.80)	TNTFPGGPITTLFNMSMSIKD..RHESVGHG...EDF..SKV.......SQNPILTSLLQITGNGGST..IG......SSP....TPP.......HHTPPPVSSM...AGNTKNHPMLMNLLKD...............nPAQdfSTLYGSSPLERQNSSSGSP
  678-  823 (130.57/55.17)	MEICPGSNKTKKKKSSRLPPDkpKHQT...E...DDF..QRElfsmdvdSQNPIFDV..NMTADTLDTphIT......PAPsqcsTPPttypqplPHPQPSIQRMvrlSSSDSIGPDVTDILSDiaeeasklpstsddcpPIG..TPVRDSSSSGHSQSALFDP
  828-  911 (88.32/30.15)	TNN.NENPYTDPADL...IAD..AAGSPSSDsptNHFfpDGV.......DFNP...DLLNSQSQGG....FGeeyfdeSSQ....SGD.......NDDFKGFASQ...ALNTLGVPML..............................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     145.41|      48|     162|      52|     108|       6
---------------------------------------------------------------------------
   52-  108 (65.36/81.28)	SGGH....QHLVSCLETLQKalKVTSlPAMTDRlESIARQNGLGSHLSASGtecyiTSDMF
  215-  266 (80.05/61.79)	SGGHlmnlKYYASPSDLLDD..KTTS.PIILHE.NNVPRSLGMNASVTIEG.....TSAMY
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20982 with Med1 domain of Kingdom Metazoa
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