<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20981

Description mediator of RNA polymerase II transcription subunit 24 isoform X2
SequenceMKVVNLKQAILQAWKERWSDYQWAINMKKFFPKGATWDILNLAEALLEQAMIGPSPNPLILSYLKYAISSQMVSYSSVLTAISKFDDFSRDLCVQALLDIMDMFCDRLSCHGKAEECIGLCRALLSALHWLLRCTAASAERLREGLEAGTPAAGEKQLALCLLRLEKTLSSTKNRALLHIAKLEEASSWTAIEHSLLKLGEILASLSNPQLRSQAEQCGTLIRSIPTMLAVHSEQLHKTGYPTVHAVVLLEGTMNLTGETQPLVEQLMMVKRMQHIPTPLFVLEIWKACFVGLIESPEGTEELKWTAFTFLKIPQVLVKLKKYCHGDKDFTEDVSCAFEFLLKLTPLLDKADQRCNCDCTKFLLQECSKQGLLSEASVTNLMAKRAADREHAPQLKSGENANIQPNPGLILRAEPTVTNILKTMDADHSKSPEGLLGVLGHMLSGKSLDLLLAAAAATGKLKSFARKFINLNEFTTHGNEELAKAASVRALLFDISFLMLCHVAQTYGSEVILSESSTGAQVPFFETWMQTCMPEEGKILNPDHPCFWPDSTKVESLVALLNNSSEMKLVQMKWHEACLSISAAILEILNAWENGVLAFESIQKITDNIKGKVCSLAVCAVAWLVAHVRMLGLDEREKSLQMIRQLAGPLYSENTLQFYNERVVIMSSILEHMCADVLQQTATQIKFPSTGVDTMPYWNLLPPKRPIKEVLTDIFAKVLEKGWVDSRSIHIFDTLLHMGGVYWFCSNLIKELLKETRKEHTLRAVELLYSIFCLDMQQVTLVLLGHILPGLLTDSSKWHSLMDPPGTALAKLAVWCALSSYSSHKGQASSRQKKRHREDIEDYISLFPLDDMQPSKLMRLLSSNEEDANILSSPTDRSMSSSLSASQLHTVNMRDPLNRVLANLFLLISSILGSRTAGPHTQFVQWFMEECVDCLEQGSRGSILQFMPFTTVSELVKVSAMSSPKVVLAITDLSLSLGRQVAAKAIAAL
Length989
PositionTail
OrganismEnhydra lutris kenyoni
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Mustelidae> Lutrinae> Enhydra.
Aromaticity0.07
Grand average of hydropathy0.049
Instability index46.62
Isoelectric point6.40
Molecular weight110083.01
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20981
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     238.25|      62|     194|     193|     263|       1
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  193-  256 (96.99/64.48)	EHS.LLKLGEILASLSNPQLRSQAEQCGTLIRSIPTMLAVHSEQlhKTGYPTVHAVVLLEGTMNL
  390-  450 (92.66/54.89)	EHApQLKSGENANIQPNPGLILRAEP..TVTNILKTMDADHSKS..PEGLLGVLGHMLSGKSLDL
  465-  505 (48.59/35.58)	ARK.FINLNE.FTTHGNEEL.AKAASVRALLFDISFLMLCHVAQ.....................
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     438.68|     143|     194|     547|     715|       2
---------------------------------------------------------------------------
  547-  715 (217.38/161.07)	FWPDSTKVESLVALLNNSSEMKLVQMKWHEACLSISAAILEILNAWENGVLAFES.IQKITDNIKGKVCSLAV.CAVAWLVAH...................VRMLGLDEREKSlQMIRQLAGPLYSENTLQFYNERVviMSSilehmcadvlqqtatqikfpSTGVDTMPYWNLlppKRPIKEVLTDIF
  742-  905 (221.30/120.32)	YWFCSNLIKELLKETRKEHTLRAVELLYSIFCLDMQQVTLVLLGHILPGLLTDSSkWHSLMDPPGTALAKLAVwCALSSYSSHkgqassrqkkrhrediedyISLFPLDDMQPS.KLMRLLSSNEEDANILSSPTDRS..MSS....................SLSASQLHTVNM...RDPLNRVLANLF
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     260.43|      90|     218|      44|     148|       3
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   44-  137 (146.36/137.61)	EALLEQAMIGPS....PNPLIL..................SYLKYAISSqMVSYSSVLTAISKF...D.DFSRDL.C.......VQALLDIMDMFCDrLSC.HGKAEECIGlcRALLS..ALHWLLRCTAA
  261-  387 (114.07/73.98)	QPLVEQLMMVKRmqhiPTPLFVleiwkacfvgliespegtEELKWTAFT.FLKIPQVLVKLKKYchgDkDFTEDVsCafefllkLTPLLDKADQRCN.CDCtKFLLQECSK..QGLLSeaSVTNLMAKRAA
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20981 with Med24 domain of Kingdom Metazoa
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