<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20978

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSSSFVPNGASLEDCHCNLFCLADLTGIKWKRYVWQGPTSAPILFPVTEEDPILSSFSRCLKADVLGVWRRDQRPGRRELWIFWWGEDPSFADLIHHDLSEEEDGVWENGLSYECRTLLFKAVHNLLERCLMNRNFVRIGKWFVKPYEKDEKPINKSEHLSCSFTFFLHGDSNVCTSVEINQHQPVYLLSEEHITLAQQSNSPFQVILSPFGLNGTLTGQAFKMSDSATKKLIGEWKQFYPISSCLKEMSEEKQEDMDWEDDSLAAVEVLVAGVRMIYPACFVLVPQSDIPTPSSVGSSHCSASCLGVHQVPASTRDPAISSVTLTPPTSPEEVQTVDPQSAQKWVKFSSVSDGFNSDSTNHHGGKIPRKLANHVVDRVWQECNMNRAQNKRKYSASSGGLSEEEIPDKVASWDFVEATQRTNCSCLRHKNLKPRNPGQQGQALSLSQQQQVLPKHKTNEKQEKSEKPQKRPLTPFHHRVSVSDDVGMDTDSASQRLVISAPDSQVRFSNIRTNDVAKTPQMHGTEMANSPQPPPLSPHPCDVVDEGVTKTPSTPQSQHFYQMPTPDPLVPSKPMEDRIDSLSQSFPAQFQEAVEPTVYVGTAVNLEEDEANIAWKYYKVPKKKDVEFLPPQLPSDKFKDDPVGPFGQESVTSVTELMVQCKKPLKVSDELVQQYQIKNQYLSAIASDAEQESKIDPYAFVEGDEEFLFPDKKERQNSEREAVKKHKGEDGPSSVTVLSHEEDAMSLFSPSIKQDAPRPTSHARPPSTSLIYDSDLAVSYTDLDNLFNSDEDELTPGSKKSANGTDDKSSSKESKTGNLDPLSCISTADLHKMYPTPPSLEQHIMGFSPMNMSNKEYGSMDITPGGTVLEGNSSSIGTQFKIEVDEGFCSPKPSEIKDFSYVYKPENCQVLVGCSMFAPLKSLPSQCLPPIKLPEECIYRQSWTVGKLELLPSGPAVPFIKEGDGSTIDQEYGPAYTPQTHTSFGMPPSSAPPSNSGAGILPSPSTPRFPTPRTPRTPRTPRAGGPASAQGSVKYENSDLYSPASTPSTCRPLNSVEPATVPSIPEAHSLYVNLILSESVMNLFKDCNFDSCCICVCNMNIKGADVGVYIPDPMQEAQYRCTCGFSAVMNRKFGNNSGLFLEDELDIIGRNTECGKEAEKRFEALRATSAEHVNGGLKESEKFPDELILLLQDQCTNLFSPFGAADQDPFPRIGVISNWVRVEERDCCNDCYLALEHGRQFMDNMSGGKVDEALVKSSCLHPWSKRNDVSMQCSQDILRMLLSLQPVLQDAIQKKRTVRPWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLLGYDYDFLVLSPFALPYWERLMLEPYGSQRDIAYVVLCPENEALLNGAKSFFRDLTAIYESCRLGQHRPISRLLTDGIMRVGSTASKKLSEKLVAEWFSQAADGNNEAFSKLKLYAQVCRYDLGPYLASQPLDSSLLSQPNLVAPTSQSLITPSQMTSTGNANTPSATLASAASSTMTMTSGVTMSSSVATANSTLTTTSTSSSSSSNLNSGVSSNKLPSFPPFGSINSSATGSMSTQASTVQNGQLGGQQSSALQTAGISGESSSLPTQPHPDVSESTMDRDKVGIPTDGDSHAVTYPPAIVVYIIDPFTYENKDESTNSSNVWTLGLLRCFLEMVQTLPPHIKNTVSVQIVPCQYLLQPVKHEDRQIYTQHLKSLAFSAFTQCRRPLPTSTNVKTLTGFGPGLAMETALKSPDRPECIRLYTPPFILAPVKDKQTELGETFGEAGQKYNVLFVGYCLSHDQRWILASCTDLYGELLETCIINIDVPNRARRKKGSARRFGLQKLWEWCLGLVQMSSLPWRVVIGRLGRIGHGELKDWSSLLSRRNLQSLSKRLKDMCRMCGISAADSPSILSACLVAMEPQGSFVIMPDSVSTGSVFGRSTTLNMQTSQLSTPQDTSCTHILVFPTSASVQVASATYTTENLDLAFNPNNDGADGMGIFDLLDTGDDLDPDIINILPASPTGSPVHSPGSHYPHGGDAGKGQGTDRLLSTESHDEVTNILQQPLALGYFVSTAKAGPLPDWFWSACPQAQYQCPLFLKASLHLHVPSVQSDELLHSKHSHPLDSNQTSDVLRFVLEQYNALSWLTCDPAIQDRRSCLPIHFVVLNQLYNFIMNML
Length2173
PositionMiddle
OrganismEnhydra lutris kenyoni
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Mustelidae> Lutrinae> Enhydra.
Aromaticity0.08
Grand average of hydropathy-0.401
Instability index52.73
Isoelectric point5.40
Molecular weight239438.28
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20978
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     243.41|      62|      67|     924|     988|       1
---------------------------------------------------------------------------
  534-  566 (48.89/17.60)	PPLS......PHP............................CDVVDEG....VTktP.STPQSQHFYQMPtP
  924-  988 (108.07/54.83)	PSQCLPPIkLPEECIYRqsWTVGKLELLPSGPAVPFIKEGDGSTIDQE....YG..PAYTPQTHTSFGMP.P
  993- 1049 (86.45/36.64)	PSNSGAGI.LPSPSTPR..FPTPRTPRTPRTPRAGGPASAQGS.VKYEnsdlYS..PASTPST.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     147.23|      45|     532|    1224|    1309|       2
---------------------------------------------------------------------------
 1259- 1309 (76.67/102.84)	CL.HP..WskrndVSMQCSqDILRMLLSLQPVLQD....AIQKKRTVRPWGVQGPLTW
 1794- 1845 (70.56/27.12)	CLsHDqrW.....ILASCT.DLYGELLETCIINIDvpnrARRKKGSARRFGLQKLWEW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     236.56|      66|      67|    1463|    1528|       3
---------------------------------------------------------------------------
 1463- 1528 (108.17/60.06)	LASQPLDSSLLSQPNLVAPTSQSLITPSQMTSTGNAN.TPSATLASAASSTMTMTSGVTMSSSVATA
 1532- 1594 (95.64/52.15)	LTTTSTSSS..SSSNLNSGVSSNKL.PS.FPPFGSINsSATGSMSTQASTVQNGQLGGQQSSALQTA
 1876- 1907 (32.75/12.47)	.......SSLLSRRNL.QSLSKRLKDMCRMCGISAAD.SPS..........................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.39|      25|     531|    1063|    1114|       5
---------------------------------------------------------------------------
 1090- 1114 (50.44/66.35)	DSCCICVCN....MNIK.GADVGVYIPDPM
 1116- 1145 (36.94/ 8.46)	EAQYRCTCGfsavMNRKfGNNSGLFLEDEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     238.92|      71|     530|      50|     209|       6
---------------------------------------------------------------------------
   51-  134 (111.82/212.82)	DPILSSFSRCLKADVLGVWRRDqrPGRRELWIFWwgedPSFADLIHHDLSEEEDGVWEnglsyecRTLLFKAVHNLLERCLMNR
  317-  387 (127.10/55.68)	DPAISSVTLTPPTSPEEVQTVD..PQSAQKWVKF....SSVSDGFNSDSTNHHGGKIP.......RKLANHVVDRVWQECNMNR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     100.33|      25|     318|     148|     172|      10
---------------------------------------------------------------------------
  148-  172 (44.89/25.07)	EKDEKPIN...KS....EH.LSCS...FTFFLHGDS
  430-  459 (23.07/ 9.13)	.KNLKPRNpgqQG....QA.LSLSqqqQVLPKHKTN
  463-  492 (32.37/15.92)	EKSEKPQK...RPltpfHHrVSVS...DDVGMDTDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.85|      20|      26|    1327|    1348|      12
---------------------------------------------------------------------------
 1327- 1348 (35.02/29.70)	P..EPLPIPTFllGYDYD..FLVLSP
 1352- 1375 (29.83/17.87)	PywERLMLEPY..GSQRDiaYVVLCP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.10|      27|      43|    1986|    2014|      13
---------------------------------------------------------------------------
 1986- 2014 (40.47/35.37)	PN.NDGADGMGIFDLLDTgDDLDpDIINIL
 2031- 2058 (44.63/27.72)	PHgGDAGKGQGTDRLLST.ESHD.EVTNIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.72|      30|     261|     606|     640|      14
---------------------------------------------------------------------------
  606-  640 (36.88/45.72)	LEEDEANIAWKyYKVpkKKDVEFLPPQlPSDkFKD
  869-  898 (53.84/36.45)	LEGNSSSIGTQ.FKI..EVDEGFCSPK.PSE.IKD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.81|      15|      26|    1595|    1611|      15
---------------------------------------------------------------------------
 1595- 1611 (19.17/22.26)	GI..SGESSSLpTQPhPDV
 1622- 1638 (24.63/13.94)	GIptDGDSHAV.TYP.PAI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20978 with Med13 domain of Kingdom Metazoa
Unable to open file!