<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20977
Description |
mediator of RNA polymerase II transcription subunit 14 isoform X1 |
Sequence | MAPVQLENHQLVPPGGGGGASGGPASAPAPPPPGAAVAAAAAAAASPGYRLSTLIEFLLHRAYSELMVLTDLLPRKSDVERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDVPWRLLKLEILVEDKETGDGRALVHSMQINFIHQLVQSRLFADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIKIDENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQKLQELKAILRGFNANENSSIETALPALVVPILEPCGNSECLHIFVDLHSGMFQLMLYGLDQATLDDMEKSVNDDMKRIIPWIQQLKFWLGQQRCKQSIKHLPTISSETLQLSNYSTHPIGNLSKNKLFIKLTRLPQYYIVVEMLEVPNKPTQLSYKYYFMSVNAAEREDTPVMALLLQQFKENIQELVFRTKPGKQPRTGPKRKLSDDPCPVEPKKTKRSGEMCAFNKVLAHFVAMCDTNMPFVGLRLELSNLEIPHQGVQMEGDGFSHAIRLLKIPPCKGVNEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWNSIARLYECVLEFARSLPDIPAHLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSIHQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPPQQQPFPKQPGSSGAYPLTSPPASYHSTVSQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPATRMPGMSPANPSLHSPVPDASHSPRAGTSSQTLPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTSVPPQEPVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQGECTIFAAVRDLMANLTLPPGGRP |
Length | 1454 |
Position | Tail |
Organism | Enhydra lutris kenyoni |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Laurasiatheria> Carnivora> Caniformia> Mustelidae> Lutrinae>
Enhydra.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.186 |
Instability index | 52.17 |
Isoelectric point | 8.97 |
Molecular weight | 160648.82 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU365082
|
GO - Cellular Component | mediator complex GO:0016592 IEA:UniProtKB-UniRule
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:UniProtKB-UniRule
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP20977
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
4| 269.73| 62| 64| 1002| 1063| 1
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1002- 1026 (30.49/ 7.04) .............................................PPPQQQPFPKQPGSSGAYPL.TSPPA
1027- 1094 (101.08/40.58) SYHSTVSQSPSMMHTQSPGNLHAASSPSGALRAP..SPA.sfvptPPPSSHGISIGPGASFASPHgTLDPS
1095- 1161 (95.58/37.96) SPYTMV..SPSGRAGNWPGS.PQVSGPSPATRMPgmSPAnpslhsPVPDASHSPRAGTSSQTLPT.NMPPP
1165- 1199 (42.58/12.78) PQRSWAASIPTIL.THSALNILLLPSPTPGL.VP..GLA................................
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 83.03| 24| 30| 1326| 1351| 2
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1326- 1351 (43.68/27.88) PdqATQLKWNVQFC..LTIPPSAPPIAP
1355- 1380 (39.36/19.21) P..AVVLKSKMLFFlqLTQKTSVPPQEP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 95.19| 29| 30| 69| 97| 3
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69- 97 (46.39/31.78) LTDLLPRKSDVERKIEIVQFASRTRQLFV
102- 130 (48.79/33.80) LVKWANNAGKVEKCAMISSFLDQQAILFV
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 266.52| 87| 159| 294| 385| 5
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294- 385 (141.22/118.18) N.....................CLHSFCLSLQLEvLHSQ..TLMLIRERWGDLVQVERYHAGKCLSLSVWNQQV...LGRKTGTASV.HKVTIKiDEndvSKPLQIFHDPPLPA.SDSKL
424- 538 (125.31/88.34) NanenssietalpalvvpilepCGNSECLHIFVD.LHSGmfQLMLYGLDQATLDDMEKSVNDDMKRIIPWIQQLkfwLGQQRCKQSIkHLPTIS.SE...TLQLSNYSTHPIGNlSKNKL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 37.33| 10| 24| 1402| 1411| 6
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1402- 1411 (17.56/ 8.48) PRQQNSSVAA
1428- 1437 (19.77/10.41) PRQGECTIFA
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 135.07| 42| 394| 810| 926| 7
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879- 926 (61.18/132.33) LNAINKLPTVPMLGLTQRTNTAYqCFSILPQSSTHIrlaFRNmyCIDI
1278- 1319 (73.89/19.04) LQVLEKFFETRVAGPPFKANTLI.AFTKLLGAPTHI...LRD..CVHI
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 46.21| 14| 29| 168| 181| 10
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168- 181 (26.56/13.17) RLPTCIRDKII....PPD
194- 211 (19.65/ 7.94) QLNQILRHRLVttdlPPQ
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 60.43| 18| 128| 595| 612| 13
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595- 612 (35.06/17.32) IQELVFRTKP..GKQPRT.GP
721- 741 (25.37/10.68) VAELVFANCPlnGTSTREqGP
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