<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20973

Description mediator of RNA polymerase II transcription subunit 23 isoform X3
SequenceMETQLQSIFEDVVKTEIIEEAFPGMFMDTPEDEKTKLISCLGAFRQFWGGLSQESHEQCIQWIVKFIHGQHSPKRISFLYDCLAMAVETGLLPPRMVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQLLAAREVIAYILERNACLLPAYFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPATLRFPLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQHKQRCPVLEDQLVDLVVYAMERSETEEKFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKEYIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLKLHHEFLQQSLRNKSLQMNDYKIALLCNAYSTNSECFTLPMGALVETIYGNGIMRVPLPGTSCLASASITPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHTLAAVAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTLARATHVTGSDSIQGTWCKDILQTIMSFTPHNWASHTLSCFPGPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMTNENDIITHFSMQGSPPLFLCLLWKMLLETDHINQIGYRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQNDWHTKHMSYHKKYPEKLYFEGLAEQVDPPVQIQSPYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYEMHLRERPHLKRKLVHAIIGSLKDNRPQGWCLSDTYLKCGMNAREENPWVPDDSYYCRLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVSGEDVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDRIVSVISSPSLTSESEWVGYPFRLFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEVLLPIVKTEFQLLYVYHLVGPFLQRFQQERTRCMIEIGVAFYDMLLNVDQCSAHLNYMDPICDFLYHMKYMFTGDSVKEQVEKIICNLKPALKLRLRFITHISKMEPAAVPPQAMSSGSPAPQANQVPGS
Length1359
PositionTail
OrganismEnhydra lutris kenyoni
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Mustelidae> Lutrinae> Enhydra.
Aromaticity0.10
Grand average of hydropathy-0.012
Instability index46.22
Isoelectric point7.00
Molecular weight155214.73
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20973
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.77|      23|      74|     770|     804|       1
---------------------------------------------------------------------------
   63-   89 (37.87/13.62)	IVKFIHGQHSPKrisfLYDCL..AMAVET
  772-  796 (38.90/34.83)	IITHFSMQGSPP....LFLCLlwKMLLET
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     365.63|      85|     257|     540|     624|       2
---------------------------------------------------------------------------
  540-  624 (141.32/83.87)	IHSIATRVIKLAHAKSSVALAPALVETYSRLLVYMEIESLG...IKGFISQLLPTV..FKSHAWGI..LHTL......LEMFSYRMHHIQP.HYRVQLL
  668-  753 (111.39/64.58)	FLSDPKTVL....SAESEELNRALILTLARATHVTGSDSIQ....GTWCKDILQTImsFTPHNWAS...HTLscfpgpLQAF.FKQNNVPQ.ESRFNLK
  799-  885 (112.92/65.56)	INQIGYRVLERIGARALV....AHVRTFADFLVYEFSTSAGgqqLNKCIEILNDMV..WKYNIVTLdrLILC......LAMRSHEGNEAQVcYFIIQLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.48|      13|      74|    1056|    1069|       5
---------------------------------------------------------------------------
 1038- 1051 (23.11/10.13)	WCLSDTYLkCGMNA
 1057- 1069 (27.38/12.66)	WVPDDSYY.CRLIG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     189.73|      56|     899|     344|     399|       6
---------------------------------------------------------------------------
  344-  399 (99.63/62.26)	FQFASFPHMV...LSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKN...ALADFLPVMK.LF
 1239- 1301 (90.10/55.60)	FQLLYVYHLVgpfLQRFQQERTRCMIEIGVAFYDMLLNVDQCSAHLNymdPICDFLYHMKyMF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     159.88|      39|     768|     174|     214|       7
---------------------------------------------------------------------------
  174-  214 (65.51/47.22)	NACL..LPAY.FAVTEIRKLYPEGKLPHWLLGNL..VSDFVDtfRP
  954-  997 (51.48/30.26)	NVCLrfLPVFdIVIHRFLELLPVSKSLETLLDHLggLYKFHD..RP
 1006- 1035 (42.89/23.90)	........HY.YEMHLRERPHLKRKLVHAIIGSL..KDN.....RP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     144.99|      47|     615|     471|     535|       8
---------------------------------------------------------------------------
  446-  514 (73.25/57.76)	PIPhslklhheflqqslrnkslqmnDYKIALLCN..AYSTNSECFTLPMGALVETIYGNGIMRVPLPGTSC
 1082- 1132 (71.75/58.85)	PFP....................ncDWRFNEFPNpaAHALHVTCVELMALAVSGEDVGNALLNVVLKSQPL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20973 with Med23 domain of Kingdom Metazoa
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