<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20966

Description mediator of RNA polymerase II transcription subunit 12-like protein
SequenceMAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSARNIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDLAGNKPLAILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQAPDPNLEWTQISTRYLREQLAKISDFYHMASSAGDGSVPVPPDVEQAMKQWEYNEKLAFHMFQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCARRLALLLSDSPSLLAAHSPHMMIGPNSSSIGAPSPGPPGPVMSPVQLAFSDFLSCAQHGPLVYGLSCMLQTVTLCCPSALVWNYSTNDNKSANPGSPLDLLQVAPSSLPMPGGNTAFNQQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSMETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAIAVAKLLEKRQAEIEAERCGESEVLDEKESISSASLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTRPRSPAGENVDEHYPKDHDMKMEEQTIMAHMGIDSGTTNIFDEVDKNDFKTDFGSEFPIFSPMPGESCENANPSLGRRMSVNGEKLLKREKPRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRTILLYGVGKERDEARHQLKKITKDILKILNKKSTTETGVGDEGPKARKNKQEAFPTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIENPSARSINYSMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACLLPQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGNNNVSSLKNDDFTMRGLRRDGNADDIWTASQNSKSCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSADLNNNSSNSGMGLFNPNGIGNTDTSSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRKVIKYEEQHHLLLYHTHPMPKPRSYYLEPLPLPPEEEEEEPTSPVSQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPISSQMLHHPQSTLWGYNLMGQPQQPGFFLQNQSLTPGGSRLDPTGSFVPTNTKQALSNMLQRRSGAMMQPPPLHAITSQQQLIQMKLLQQQQQQRLLRQAQARPFQQGPPGDQAALFAAQARPSPQLSQYPGLQQAQTMPQGYTMYGTQMPLQQTPQQQAGGVLLSPNYNSRTYPAAHSNPALMERLRQMQQQPSGYVQQQASPYLQPLTGSQRLNHQSLQQSPLVGGGIDAVLTSTHPSLPSVPLPQDPMRPRQPQVRQQQRLLQMQQPPQPQQPPQPQSQTLGLQAMQPQQPLFPRQGLQQTQQQQQTAALVRQLQKQLSSKYTTS
Length2162
PositionKinase
OrganismEnhydra lutris kenyoni
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Mustelidae> Lutrinae> Enhydra.
Aromaticity0.07
Grand average of hydropathy-0.425
Instability index56.62
Isoelectric point7.49
Molecular weight241902.01
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20966
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.16|      17|      18|    2087|    2104|       1
---------------------------------------------------------------------------
 1949- 1965 (24.68/ 8.55)	ALFAAQAR..P.SPQLSQYP
 2097- 2116 (26.48/13.90)	RLLQMQQPpqPqQPPQPQSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.41|      26|     286|    1359|    1398|       2
---------------------------------------------------------------------------
 1332- 1357 (45.56/37.04)	IKEC.TEGDNLQRQHIKRILQNLEQWT
 1369- 1395 (38.85/23.04)	IKQClKDPGSGSVAEMNNLLDNIAKAT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     233.90|      42|      44|     917|     958|       3
---------------------------------------------------------------------------
  917-  958 (74.64/49.26)	C..IVAVL.RRYHS............CLILNPDQTAQVFEGL...CGVVKHV..VNPS....ECSS
  962-  996 (42.15/24.14)	C..ILAYLyDLYVS............CSHLRS.KFGDLFSSA...CSKVKQT..I...........
 1077- 1107 (33.79/17.66)	..........................CTVLSSEWLG.VLKAL...CCSSNHVwgFNDV....LC.T
 1108- 1153 (32.93/17.00)	V..DVSDL.SFHDSlatfiailiarqC...........F.SL...EDVVQHV..ALPSllaaACGD
 1164- 1206 (50.40/30.51)	CrlLLHLF.RAPQA............CL.L.PQATGKPFPGIrssCD..RHL..LAAA....HNSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     261.66|      36|      67|    1844|    1879|       4
---------------------------------------------------------------------------
 1659- 1684 (24.64/ 6.40)	...........................QL.....LP..LP..KQTCDVI...TCEP..MGSLIDTKG
 1722- 1777 (34.65/12.09)	LSWAWfGtvrvdrkvikyeeqhhlllYHT.....HP..MP..KPRSYYLEPLPLPP..EEEEEEPTS
 1844- 1879 (66.62/30.25)	QSTLW.G...................YNL.....MG..QP..QQPGFFLQNQSLTP..GGSRLDPTG
 1884- 1906 (28.98/ 8.86)	TNT....................................K..QALSNMLQRRS......GAMMQPPP
 1913- 1945 (37.78/13.86)	QQQLI.Q...................MKL.....LQ..QQ..QQQRLLRQAQA.RPfqQG....PPG
 1971- 2001 (29.54/ 9.18)	QTMPQ.G...................YTM.....YGtqMPlqQTP....QQQA.....GGVLLSP..
 2056- 2096 (39.47/14.82)	QSPLV.G...................GGIdavltST..HP..SLPSVPLPQDPMRP..RQPQVRQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.08|      19|     193|      21|      45|       5
---------------------------------------------------------------------------
   21-   45 (27.66/31.71)	PPDVyPQDPKQKEdeltaVNVKQGF
  220-  238 (38.43/23.13)	PPDV.EQAMKQWE.....YNEKLAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.73|      20|     193|    1226|    1254|       6
---------------------------------------------------------------------------
 1226- 1245 (33.56/41.86)	IGNNNVSSLKNDDFTMRGLR
 1256- 1275 (32.17/14.77)	ASQNSKSCGKSISIETANLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.60|      19|     286|     386|     411|       7
---------------------------------------------------------------------------
  386-  411 (27.41/33.61)	NDNKSaNPGSPLDLLQvapsslPMPG
  680-  698 (39.19/24.25)	NDFKT.DFGSEFPIFS......PMPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.36|      21|     286|     738|     776|      11
---------------------------------------------------------------------------
  738-  776 (25.48/48.75)	RHLqyathfpipldessshecNQRTILLYGVGKERDEAR
  788-  808 (35.87/19.74)	KIL..................NKKSTTETGVGDEGPKAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.99|      22|      25|    1575|    1598|      17
---------------------------------------------------------------------------
 1575- 1598 (33.79/32.32)	WTTdwALLLLQIITSGTVDMHTNN
 1601- 1622 (36.20/24.85)	FTT..VLDMLGVLINGTLASDLSN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.81|      17|      27|    1514|    1530|      19
---------------------------------------------------------------------------
 1514- 1530 (28.61/18.42)	QDE..QREGLLTSLQNQVN
 1542- 1560 (25.21/15.23)	QDDikARQMMHEALQLRLN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.58|      13|     287|    1030|    1047|      20
---------------------------------------------------------------------------
 1030- 1042 (20.51/20.17)	MLGKILSDNAANR
 1050- 1062 (24.07/ 8.21)	LMNVCMGHQDAGR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20966 with Med12 domain of Kingdom Metazoa
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