<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20959

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMDVSGQETDWRSTAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQSLTGGPAAGAAGIGMPSRGPGQSLGGMGGLGTMGQPMPLSGQPPPGPSGMAPHGMAVVSTAAPQTQLQLQQVALQQQQQQFQQQQVALQQQQQQQQQQQQQQFQAQQNAMQQQFQAVVQQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQLQRMAQLQLQQQQQQQQQALQAQPPLQQPPMQQPQPPPSQALPQQLQPMHHPQHHQPPPQPQQPPVAPNQPSQLPPQSQTQPLVSQAPALPGQMLYAQPQLKLVRTPMVVQQPQVQPQVQQVQPQVQQQTAVPTAQASQIVGSGVQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCTRKRRFEDDERQTIPNVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSIHQACLSAA
Length730
PositionTail
OrganismEnhydra lutris kenyoni
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Mustelidae> Lutrinae> Enhydra.
Aromaticity0.03
Grand average of hydropathy-0.724
Instability index87.82
Isoelectric point9.38
Molecular weight80622.66
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20959
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.73|      25|      29|     391|     419|       4
---------------------------------------------------------------------------
  369-  413 (37.69/ 6.46)	VPtaqasqivgsgvqvqtpqsmPPPPQPSPQPGQ.PSSQPNSNVSS
  414-  444 (26.05/ 6.01)	GP...............apspsSFLPSPSPQPSQsPVTARTPQNFS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     163.76|      28|      29|     180|     207|       5
---------------------------------------------------------------------------
  193-  220 (47.24/11.44)	QNAMQQQFQAVVQQQ.........qQQLQQQQQ...Q.QQH
  227-  260 (39.80/ 8.36)	QN..QQQIQQ..QQQlqrmaqlqlqQQQQQQQQ...ALQAQ
  310-  344 (34.74/ 6.26)	QLPPQSQTQPLVSQA...palpgqmLYAQPQLK...LVRTP
  345-  375 (41.99/ 9.27)	MVVQQPQVQPQVQQV..........QPQVQQQTavpTAQAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      79.55|      18|      36|      82|     102|       6
---------------------------------------------------------------------------
   82-  102 (30.17/20.06)	MnalQSLTGGPAAGAAGI...GMP
  108-  122 (24.51/ 8.31)	....QSL..GGMGGLGTM...GQP
  123-  141 (24.87/ 9.39)	M....PLSGQPPPGPSGMaphGM.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.40|      23|      28|     505|     531|       7
---------------------------------------------------------------------------
  496-  523 (35.23/23.13)	DKNEdrkkdLSKMKSLLDILTDPSKRCP
  528-  552 (39.17/17.38)	QKCE...iaLEKLKNDMAVPTPPPPPVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.00|      18|     137|     445|     473|       8
---------------------------------------------------------------------------
  446-  466 (26.93/27.66)	PSPGPLNTPVnPSSVmsPAGS
  658-  675 (35.07/ 7.41)	PSVPPLELSV.PADY..PAQS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20959 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HNKKSQASVSDPMNALQSLTGGPAAGAAGIGMPSRGPGQSLGGMGGLGTMGQPMPLSGQPPPGPSGMAPHGMAVVSTAA
2) QQQQQQALQAQPPLQQPPMQQPQPPPSQALPQQLQPMHHPQHHQPPPQPQQPPVAPNQPSQLPPQSQTQPLVSQAPALPGQMLYAQPQLKLVRTPMVVQQPQVQPQVQQVQPQVQQQTAVPTAQASQIVGSGVQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQ
70
250
148
480










Molecular Recognition Features






MoRF SequenceStartStop




NANANA