<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20958

Description mediator of RNA polymerase II transcription subunit 26
SequenceMTAAPASPQQIRDRLLQAIDPQSNIRNMVAVLEVISSLEKYPITKEALEETRLGKLINDVRKKTKNEELAKRAKKLLRSWQKLIEPVHQNEAALRGLAGGTGSANGGAHNCRPEVGAAGAPKSIHDLKNRNDIQRLPGQRLDRLGSRKRRGDQRDLGHPGPPPKVSKASHDSLVPNSSPLPTNGIGGSPESFPGTLDGSGHTGPEGGRLEHGESDKHSGKIPVNAVRPHTSSPGLGKPPGPCLQTKAGVLQQMDRVDETPGPPHPKGLIRCSFSPRNSRHEGSFARQRSPYTPKGSMPSPSPRPQALDATQVPSPLPLAQPSTPPVRRLELLSSAESPVRWLEQPEGHQRLAGQGCKVGLPPSEPHLPRAGFSPDSSKADSDAASSGGSDSKKKKRYRPRDYTVNLDGQVAEAGVKPVRLKERKLTFDPMTRQIKPLTQKEPVRADSPVHTEQPRTELDKPEAKASVQSPFEQTNWKELSRNEIIQSYLSRQSSLLSSSGAQTPGAHHFMSEYLKQEESTRRGSRKPHVLVPHSAPTDLPGLNREVTQDDLDRIQAHQWPGVNGCQDTQGNWYDWTQCISLDPHGDDGRLNILPYVCLD
Length599
PositionUnknown
OrganismEnhydra lutris kenyoni
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Mustelidae> Lutrinae> Enhydra.
Aromaticity0.04
Grand average of hydropathy-0.887
Instability index57.94
Isoelectric point9.49
Molecular weight65386.64
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20958
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     117.55|      19|      22|     289|     307|       1
---------------------------------------------------------------------------
  178-  196 (29.06/ 8.92)	SPLPTNGIGG.SPESFPGTL
  261-  280 (26.78/ 7.67)	GPPHPKGLIRcSFSPRNSRH
  289-  307 (36.72/13.11)	SPYTPKGSMP.SPSPRPQAL
  334-  351 (24.98/ 6.69)	SAESPVRWLE.QPEGH.QRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.42|      20|     208|     151|     172|       2
---------------------------------------------------------------------------
  152-  171 (39.17/18.81)	DQRDLGHPGPPPKVSKASHD
  363-  382 (35.26/ 9.03)	SEPHLPRAGFSPDSSKADSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.30|      13|      14|     100|     112|       3
---------------------------------------------------------------------------
  100-  112 (24.33/13.43)	GTGSANGGAHNCR
  116-  128 (21.97/11.45)	GAAGAPKSIHDLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     191.16|      44|     354|     201|     244|       4
---------------------------------------------------------------------------
  201-  244 (81.15/37.30)	HTGP..EGGRLEHGESDKHSGKIPVNAVRPHTSSPGLGKPPGPCLQ
  514-  541 (34.16/11.84)	..........LKQEESTRRGSRKP.HVLVPHSAPTDL...PG....
  557-  599 (75.85/34.43)	HQWPgvNGCQDTQGNWYDWTQCISLD...PHGDDGRLNILPYVCLD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20958 with Med26 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HQNEAALRGLAGGTGSANGGAHNCRPEVGAAGAPKSIHDLKNRNDIQRLPGQRLDRLGSRKRRGDQRDLGHPGPPPKVSKASHDSLVPNSSPLPTNGIGGSPESFPGTLDGSGHTGPEGGRLEHGESDKHSGKIPVNAVRPHTSSPGLGKPPGPCLQTKAGVLQQMDRVDETPGPPHPKGLIRCSFSPRNSRHEGSFARQRSPYTPKGSMPSPSPRPQALDATQVPSPLPLAQPSTPPVRRLELLSSAESPVRWLEQPEGHQRLAGQGCKVGLPPSEPHLPRAGFSPDSSKADSDAASSGGSDSKKKKRYRPRDYTVNLDGQVAEAGVKPVRLKERKLTFDPMTRQIKPLTQKEPVRADSPVHTEQPRTELDKPEAKASVQSPFEQTNW
2) RQSSLLSSSGAQTPGAHHFMSEYLKQEESTRRGSRKPHVLVPHSAPTDLPGLNREVTQDDLDRIQAHQWP
88
491
476
560










Molecular Recognition Features






MoRF SequenceStartStop




1) IRDRLL
2) KKKKRYRPRDYTVNLDGQ
3) RRLELL
11
392
327
16
409
332