<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20932

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMDVSGQETDWRSAAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQNLTGAPAAGATGINMAGRGPGQTLGGMGSLGAMGQPPPGTSGIAPHGMAVVSTATPQTQLQLQQVALQQQQQQFQQQQAALQQQQQFQAQQSAMQQQFQAVVQQQQQQLQQQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRMAQLQLQQQQQQQQQALQAPPMQQSPMQQPQPPPTQALPQQLQQMHHPQHHQPPPPPPQQPPVAQNQPLQLPPQSVTSQAPALPGQMLYTQQQLKLVRAPMVVQQPQVQPQVQPQVQQQTAVQTPQAAQMVASGVQMITAAMAQGGMQVRARFPPSTAVSAAPPGALPTGGQPPAQVSQSSLPMLSSPSPGQQVPTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFMPPMAAIHGPPITVPAVCTRKRKFEDDERQSIPNVLQGEVARLDSKFLVNLDPSHCSNNGTVHLICKLDDRDLPSVPPLELSVPADYPAQSPLWVDQQWQYDANPFLQSVYRCMTSRLLQLPDKHSVTALLNTWAQSVHQACLSNA
Length767
PositionTail
OrganismTrichechus manatus latirostris (Florida manatee)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Afrotheria> Sirenia> Trichechidae> Trichechus.
Aromaticity0.04
Grand average of hydropathy-0.657
Instability index83.17
Isoelectric point9.42
Molecular weight84060.62
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20932
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.02|      34|      35|     424|     458|       1
---------------------------------------------------------------------------
  275-  313 (54.51/10.03)	PQHHQPPPPPPQQPPvaqnQPLQLPPQSVTS.QAPAlPGQ
  424-  458 (65.51/15.81)	PQSMPPPPQPSPQPG....QPSSQPNSNVSSgPAPS.PSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     145.67|      34|      35|     189|     222|       2
---------------------------------------------------------------------------
  172-  206 (47.51/ 9.69)	....QFQAQQ.SAMQQ.QfqavvQQQQQ..QLQQQQQQQQQQH
  207-  242 (59.37/14.08)	LIKLHHQNQQ.QIQQQ.Q.....QQLQRmaQLQLQQQQQQQQQ
  323-  356 (38.79/ 6.47)	LVRAPMVVQQpQVQPQvQ.....PQVQQ..QTAVQTPQAAQ..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.39|      20|      28|      82|     103|       4
---------------------------------------------------------------------------
   82-  102 (31.16/14.17)	MNALQNLtGAPAAGATGI...NMA
  113-  135 (35.23/12.27)	MGSLGAM.GQPPPGTSGIaphGMA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     167.94|      57|     117|     554|     619|       5
---------------------------------------------------------------------------
  554-  619 (83.17/53.06)	DPSkRCPLK.TLQ.KCeialeKLkNDMAVPTPPPPPVpPTKQQYLCQ.PL.LDAVLANIRSPvFNHSLYR
  673-  733 (84.77/34.17)	DPS.HCSNNgTVHlIC.....KL.DDRDLPSVPPLEL.SVPADYPAQsPLwVDQQWQYDANP.FLQSVYR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.38|      27|      97|     378|     406|       6
---------------------------------------------------------------------------
  378-  406 (47.67/17.51)	ARFPPSTAVSAapPGALPTGGQP.....PAQVSQ
  474-  505 (44.70/12.12)	ARTPQNFSVPS..PGPLNTPVNPssvmsPAGSSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.20|      22|      97|     148|     171|       7
---------------------------------------------------------------------------
  148-  171 (34.16/14.92)	LQQVALqqQQQQFQQQQAALQQQQ
  249-  270 (43.03/15.18)	MQQSPM..QQPQPPPTQALPQQLQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20932 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) APMVVQQPQVQPQVQPQVQQQTAVQTPQAAQMVASGVQMITAAMAQGGMQVRARFPPSTAVSAAPPGALPTGGQPPAQVSQSSLPMLSSPSPGQQVPTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLS
2) KSQASVSDPMNALQNLTGAPAAGATGINMAGRGPGQTLGGMGSLGAMGQPPPGTSGIAPHGMAVVS
3) QQQQQQQALQAPPMQQSPMQQPQPPPTQALPQQLQQMHHPQHHQPPPPPPQQPPVAQNQPLQLPPQSVTSQAPALPGQMLYTQ
326
73
236
519
138
318










Molecular Recognition Features






MoRF SequenceStartStop




NANANA