<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20929

Description mediator of RNA polymerase II transcription subunit 26
SequenceMTAAPASPQQIRDRLLQAIDAQSNIRNMVAVLEVISSLEKYPITKEALEETRLGKLINDVRKKTKNEELAKRAKKLLRSWQKLIEPVHQGEAALRGLPGTAGSANGGAHNCRPEVGAAAGPRSIHDLKSRNDIQRLPGQRLDRPGSRKRRGDQRDLGHPGPPPKAAKASHEPLAPNSSPLPTNGITGSPESFTGPLDSSGHTGPEGSRLEPGENDKHSGWIPVNAVRPHTSSPGPGLGAKTASLQPLDRVDETPGPPHPRGPPRCSFSPRNSRHEGPFARQQSPYVPKGSVPSPSPRPLSLEATQAPSPLPLAQPPTPPVRRLELLPSAESPGCWPDQPEGHQRLAGPGCKAGLPPAEPLLLLPRAGLSPDSSRADSDAASSGGSDSRKKKRYRPRDYTVNLDGQGAEAGVKPVRLKERKLTFDPMTRQIKPLTQKEPVQAESPARTEPPRTELDAQEPRGGLQSPFEQTNWKELSRNEMIQSYLSRQSSLLSSSGAQTPGAHHFMSEYLRQEESAKRHGAHETHVLAPHSPPADLPGHTREITQDDLERIQAHQWPGVNGCYDTQGTWYDWTQCIALDPHGDDGRLNILPYVCLD
Length596
PositionUnknown
OrganismTrichechus manatus latirostris (Florida manatee)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Afrotheria> Sirenia> Trichechidae> Trichechus.
Aromaticity0.04
Grand average of hydropathy-0.877
Instability index61.44
Isoelectric point9.09
Molecular weight64700.68
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20929
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     547.21|     111|     112|     137|     247|       1
---------------------------------------------------------------------------
  137-  247 (199.06/58.06)	PGQRLDR.PGSRKRRGDQRDLGHP.GPP.....PKAAKASHE.PLAPNSSPL.PTNGITGS.PESFTGPLD...SSGHTGPEGSRLEPGENDKH.SGWIPVNAVRP.HTSSPGPGLGAKTASLQPL
  249-  323 (93.15/23.79)	...RVDEtPGP....P......HPrGPPrcsfsPRNSR..HEgPFARQQSPY.VPKGSVPS.P................SPRPLSLEATQ..................APSPLPLAQPPTPPVRRL
  332-  433 (141.49/39.43)	PGCWPDQ.P.....EGHQR.LA...GPG.....CKAGLPPAE.PLL....LL.PRAGL..S.PDSSRADSDaasSGGSDSRKKKRYRPRDYTVNlDGQGAEAGVKPvRLKERKLTFDPMTRQIKPL
  435-  529 (113.51/30.37)	...........QKEPV.QAESPAR.TEP.....PRTELDAQE.PRGGLQSPFeQTNWKELSrNEMIQSYLS..rQSSLLSSSGAQ.TPGAHHFM.SEYL.....RQ.EESAKRHG.AHETHVLAP.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.56|      12|      17|      90|     101|       2
---------------------------------------------------------------------------
   90-  101 (20.60/10.64)	GEAALRGLPGTA
  107-  118 (22.96/12.74)	GAHNCRPEVGAA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20929 with Med26 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) SYLSRQSSLLSSSGAQTPGAHHFMSEYLRQEESAKRHGAHETHVLAPHSPPADLPGHTREITQDDLERI
2) VHQGEAALRGLPGTAGSANGGAHNCRPEVGAAAGPRSIHDLKSRNDIQRLPGQRLDRPGSRKRRGDQRDLGHPGPPPKAAKASHEPLAPNSSPLPTNGITGSPESFTGPLDSSGHTGPEGSRLEPGENDKHSGWIPVNAVRPHTSSPGPGLGAKTASLQPLDRVDETPGPPHPRGPPRCSFSPRNSRHEGPFARQQSPYVPKGSVPSPSPRPLSLEATQAPSPLPLAQPPTPPVRRLELLPSAESPGCWPDQPEGHQRLAGPGCKAGLPPAEPLLLLPRAGLSPDSSRADSDAASSGGSDSRKKKRYRPRDYTVNLDGQGAEAGVKPVRLKERKLTFDPMTRQIKPLTQKEPVQAESPARTEPPRTELDAQEPRGGLQSPFEQTNWKELS
483
87
551
476










Molecular Recognition Features






MoRF SequenceStartStop




1) LLLLPR
2) RKKKRYRPRDYTVNLDGQ
3) RRLELL
360
388
321
365
405
326