<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20927

Description mediator of RNA polymerase II transcription subunit 25
SequenceMPCTNMAAGASAAAGSRPARGRAQRRRTSGHSAEVAVVEVVVAGRGMVPGSEGPARAGGLVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSSAYEFVTWLDGIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGYTTENLVQKIGERGIHFSIVSPRKLPALRLLFEKAAPPALLEPLQPLTDVSQDPRHMVLVRGLVLPVGGSSAPGPLQPKQPVPLPPAPTSGATLSAAPQQPLPPVPQQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPINPLQQAAPGVGPPFSQASAPPLPPGPPGAPKPPPVSQPSLVSSVAPGPGLAPPAQPGAPSMAGSVAPVGVSGPSPAQLGAPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHKQVQQQKLEQQRGMGGQQAPAGLGPILEDQARPTQNLLQLRPPQPQPPGAVGATGAAGQPQPQGAAQAPQGAPQGPPGAAPGPPPPGPILRPQNPGANPQLRSLLLNPPPPQSGVPPPQASLHHLQPPGAPALLPPPHQGLGQPQLGPPLLHPPPTQSWPAQLPPRASLPGQMLLSGGPRGPVPQPGLQPSVMEDDILMDLI
Length792
PositionUnknown
OrganismTrichechus manatus latirostris (Florida manatee)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Afrotheria> Sirenia> Trichechidae> Trichechus.
Aromaticity0.05
Grand average of hydropathy-0.224
Instability index58.35
Isoelectric point9.14
Molecular weight82684.99
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20927
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.44|      18|      26|     360|     382|       2
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  360-  382 (39.53/15.92)	PGVGPPfsqasAPPLPPGPPGAP
  671-  688 (32.91/ 6.11)	PGPPPP.....GPILRPQNPGAN
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     127.53|      26|      26|     614|     639|       3
---------------------------------------------------------------------------
  271-  296 (43.67/10.35)	GLVLPVGGSSAPGPLQPKQPVPLPPA
  300-  319 (35.73/ 7.06)	GATLS..AAPQQP.L...PPVPQQYQ
  614-  639 (48.13/12.20)	GPILEDQARPTQNLLQLRPPQPQPPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.82|      31|     111|      85|     115|       7
---------------------------------------------------------------------------
   85-  115 (58.32/34.87)	YLLPAIEYFNGGPPAETDFGGDYG..GTQYSLV
  197-  229 (49.51/28.44)	YLLPAVESTTYSGYTTENLVQKIGerGIHFSIV
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.53|      20|     258|     487|     509|       8
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  475-  500 (24.64/16.12)	CQVYVNHGenlkTEQwpQKLIMQ..LIP
  584-  606 (20.89/ 9.39)	RQVITNHK...qVQQ..QKLEQQrgMGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.62|      22|      25|     510|     533|       9
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  510-  533 (34.11/26.22)	LFrnSRMVQF.HFTNKDLESLKGLY
  539-  561 (37.50/22.28)	GF..AGCVHFpHTAPCEVRVLMLLY
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.53|      14|     321|     427|     442|      10
---------------------------------------------------------------------------
  434-  450 (18.18/10.00)	ALGGQQSVSnklLAWSG
  451-  464 (24.35/ 7.55)	VLEWQEKPK...PASVD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.64|      30|     269|      48|      78|      12
---------------------------------------------------------------------------
   48-   78 (49.30/32.21)	VPGSEGPARAGGLVAdVVFVIEGTANLGPYF
  320-  349 (48.33/27.10)	VPGNLSAAQVAAQNA.VEAAKNQKAGLGPRF
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.09|      19|      29|     144|     162|      14
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  144-  162 (34.59/24.53)	LDGIKFM....GGGGESCSLIAE
  171-  193 (31.50/21.65)	FDDFKKMreqiGQTHRVCLLICN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     126.85|      37|     522|     231|     269|      15
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  231-  269 (61.63/31.11)	PR.KLPALRLLFEKAAPPALLEPLQPltDVSQDPRHMVLV
  755-  792 (65.22/28.59)	PRaSLPGQMLLSGGPRGPVPQPGLQP..SVMEDDILMDLI
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20927 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GSSAPGPLQPKQPVPLPPAPTSGATLSAAPQQPLPPVPQQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPINPLQQAAPGVGPPFSQASAPPLPPGPPGAPKPPPVSQPSLVSSVAPGPGLAPPAQPGAPSMAGSVAPVGVSGPSPAQLGAPALG
2) HKQVQQQKLEQQRGMGGQQAPAGLGPILEDQARPTQNLLQLRPPQPQPPGAVGATGAAGQPQPQGAAQAPQGAPQGPPGAAPGPPPPGPILRPQNPGANPQLRSLLLNPPPPQSGVPPPQASLHHLQPPGAPALLPPPHQGLGQPQLGPPLLHPPPTQSWPAQLPPRASLPGQMLLSGGPRGPVPQPGLQPSVMEDDILMD
278
590
436
790










Molecular Recognition Features






MoRF SequenceStartStop




NANANA