<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20925

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTAAANWVANGASLEDCHSNLFSLAELTGIKWRRYNFGGHGDCGPIISAPAQDDPILLSFIRCLQANLLCVWRRDVKPDCKELWIFWWGDEPNLVGVIHHELQVVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFVRPYEKDEKPVNKSEHLSCAFTFFLHGESNVCTSVEIAQHQPIYLINEEHIHMAQSSPAPFQVLVSPYGLNGTLTGQAYKMSDPATRKLIEEWQYFYPMVLKKKEELKEEEELGYDDDFPVAVEVIVGGVRMVYPSAFVLISQNDIPVPQSGASAGGHITVGQQGLGSVKDPSNCGMPLTPPTSPEQVLIGESGGTQSAVSHLGSQEGGMITMHSPKRSGKIPPKLHNHMVHRVWKECILNRTQSKRSQVSTPTLEEEPANSPATWDFVDPTQRVSCSCSRHKLLRRCAAGPNRPPTISQPGFSAGPSSSSSLPPPASSKHKTTERQEKGDKLQKRPLIPFHHRPSVAEELCMEQDTPGQKLGLAGIDSSLEVSSSRKYDKQMAVPSRNTSKQMNLNPMDSPHSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYGNGLELQQLSTLDDRTVLVGQRLPLMAEVSETALYCGIRPSNPESSDKRWHSYCLPPSDDAEFRPPELQGERCDAKMEVNSESTALQRLLAQPNKRFKIWQDKQPQMQPLHFLDPLPLTQQPGDSLGEVNDPYTFEDGDIKYIFTANKKCKQGTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTDVRQDNAAGRAGSGSLTQVTDLAPSLHDLDNIFDNSDDDELGAVSPALRSSKMPTVGTEDRPLGKDGRTAVPYPPTVADLQRMFPTPPSLEQHPAFSPVMNYKDGISSETVTALGMMESPMVSMVPTQLTEFRMEVEDGLGSPKPEEIKDFSYVHKVPTFQPFVGSSMFAPLKILPSQCLLPLKIPDACLFRPSWAIPPKIEQLPMPPAATFIRDGYNNVPSVGSLADPDYLNTPQMNTPVTLNSAAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQPIPEAHSLYVTLILSDSVMNIFKDRNFDSCCICACNMNIKGADVGLYIPDSSNEDQYRCTCGFSAIVNRKLGYNSGLFLEDELDIFGKNSDIGQAAERRLMLCQTTFLPQLEGARKSQEPPISLLLLLQNQHTQPFASLSFLDYISSNSRQALPCVSWSYDRVQADNNDYWTECFTALEQGRQYVDNPTGGKVDEALVRSATAHSWPHSNVLDISMLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGTYGSEESPEPLPIPTLLVGYDKDFLTISPFSLPFWERLLLDPYGGHRDVAYIVVCPENEALLEGAKTFFRDLSAVYEMCRLGQHKPICKVLRDGIMRVGKTVAQKLTDELVSEWFSQPWGSEENDNHSRLKLYAQVCRHHLAPYLATLQLDSSLLIPPKYQTPPAAQGQATPGNAGPLASNSGSAVPPAGSAFNPTSNGSSANPAASSSAPGSSVPPVSSSSSAPGINQMSTTSSSGFSGSVGGQNPSTGGSSADRTQGNIGCGGDTEPGQSSAQPSQDGQESVTERERIGIPTEPDSADSQAYPPAVVIYMVDPFTYTSEEDSTSGNFWLLSLMRCYTEMLDNLPEHMRNSFILQIVPCQYMLQTMKDEQVFYIQYLKSMAFSVYCQCRRPLPTQIHIKSLTGFGPAASIEMTLKNPERPSPIQLYSPPFILAPIKDKQTELGETFGEASQKYNVLFVGYCLSHDQRWLLASCTDLHGELLETCIVNIALPNRSRRSKVSARKIGLQKLWEWCIGIVQMTSLPWRVVIGRLGRLGHGELKDWSILLGECSLQTISKQLKDVCRMCGISAADSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNMQSSQLNTPQDASCTHILVFPTSSTIQVAPANYPNEDGFSPNNDDMFVDLPFPDDMDNDIGILMTGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPEELKQQPLALGYFVSTARAENLPQWFWSSCPQAQNQCPLFLKASLHHHISVAQTDELLPARNSQRVPHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRTSCLPVHFVVLTQLYNAIMNIL
Length2210
PositionMiddle
OrganismTrichechus manatus latirostris (Florida manatee)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Afrotheria> Sirenia> Trichechidae> Trichechus.
Aromaticity0.07
Grand average of hydropathy-0.385
Instability index58.82
Isoelectric point5.61
Molecular weight242562.62
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20925
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.36|      24|      28|    1533|    1560|       1
---------------------------------------------------------------------------
 1533- 1560 (37.88/26.42)	PAAQGqaTPGNagPLASNS..GSAVPPAGS
 1564- 1589 (41.48/18.17)	PTSNG..SSAN..PAASSSapGSSVPPVSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.47|      22|      28|    1613|    1640|       2
---------------------------------------------------------------------------
 1613- 1638 (33.30/32.14)	GQNPSTGG..SSADRTQgnIGCGgdTEP
 1642- 1665 (36.16/14.68)	SAQPSQDGqeSVTERER..IGIP..TEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     188.27|      28|      28|    1034|    1061|       3
---------------------------------------------------------------------------
  406-  431 (28.23/ 9.98)	...ANSPA..T....WDFVDPTQRVScSCSRHKLL
  432-  458 (31.78/12.36)	RRCAAGP.nrP....PTISQPGF..S.AGPSSSSS
  824-  848 (25.05/ 7.84)	...AVSPAlrS....SKM..PTVGTE.DRPLGKDG
  849-  875 (27.20/ 9.29)	RTAVPYPP..TvadlQRM.FPTP..P.SLEQHP..
 1035- 1062 (49.62/24.37)	AGVLPSPA..T....PRFSVPTPRTP.RTPRTPRG
 1063- 1090 (26.40/ 8.75)	GGTASGQG..S....VKYDSTDQGSPaSTPSTTR.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.39|      14|      16|     611|     625|       4
---------------------------------------------------------------------------
  611-  625 (21.75/13.94)	EVSETAL..YCgIRPSN
  627-  642 (24.64/11.15)	ESSDKRWhsYC.LPPSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.98|      14|      16|     556|     569|       5
---------------------------------------------------------------------------
  556-  569 (27.17/11.56)	PPTLSPQP..RGQETE
  573-  588 (22.81/ 8.45)	PPSVPVNPalYGNGLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.06|      17|      17|     897|     913|       6
---------------------------------------------------------------------------
  897-  913 (31.15/17.14)	M.MESPMVSMVPTQLTEF
  915-  932 (25.91/12.90)	MeVEDGLGSPKPEEIKDF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.44|      14|      17|     770|     786|       7
---------------------------------------------------------------------------
  770-  783 (23.27/22.69)	NAMSIFSSATKTDV
  787-  800 (23.16/10.46)	NAAGRAGSGSLTQV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.90|      28|      28|    2068|    2095|       8
---------------------------------------------------------------------------
 2068- 2095 (47.71/23.42)	GSHFQHSRSQG.ERLLSREAPEELKQQPL
 2098- 2126 (50.19/25.00)	GYFVSTARAENlPQWFWSSCPQAQNQCPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.40|      20|      21|     949|     969|       9
---------------------------------------------------------------------------
  949-  969 (32.92/19.83)	MFAPLKILPSQC.LLPLKiPDA
  971-  991 (35.48/17.36)	LFRPSWAIPPKIeQLPMP.PAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.09|      18|      28|    1134|    1158|      10
---------------------------------------------------------------------------
 1134- 1151 (36.36/32.46)	CACNM....NIK.GADVGLYIPD
 1160- 1182 (26.73/ 8.18)	CTCGFsaivNRKlGYNSGLFLED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.95|      20|      20|    1687|    1706|      12
---------------------------------------------------------------------------
 1687- 1706 (37.19/20.37)	YTSEEDSTS...GNFWLLSLMRC
 1707- 1729 (31.76/16.33)	YTEMLDNLPehmRNSFILQIVPC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.65|      14|      20|    1376|    1389|      14
---------------------------------------------------------------------------
 1376- 1389 (26.81/11.79)	SPEPLPI..PTLLVGY
 1397- 1412 (22.84/ 8.92)	SPFSLPFweRLLLDPY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.95|      25|      25|      60|      84|      16
---------------------------------------------------------------------------
   60-   84 (48.05/36.93)	FIRCLQANLLCVWRRDVKPDCKELW
   86-  110 (47.90/36.79)	FWWGDEPNLVGVIHHELQVVEEGLW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.41|      14|      16|     225|     240|      17
---------------------------------------------------------------------------
  225-  238 (24.00/21.65)	YKMSDPATRKLIEE
  243-  256 (23.41/10.53)	YPMVLKKKEELKEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.37|      18|      28|    2019|    2041|      18
---------------------------------------------------------------------------
 2019- 2041 (25.52/26.22)	SPNNDdmfvDLPFPDDmDNDIGI
 2050- 2067 (34.86/17.78)	SPNSS....PVPSPGS.PSGIGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.55|      10|     911|     180|     189|      22
---------------------------------------------------------------------------
  180-  189 (19.55/13.43)	SVEIAQHQPI
 1094- 1103 (20.00/13.98)	SVEPATMQPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.64|      18|      27|     462|     479|      25
---------------------------------------------------------------------------
  462-  479 (29.93/19.73)	PASSKHKTTERQEKGDKL
  491-  508 (31.71/21.42)	PSVAEELCMEQDTPGQKL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20925 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) CAAGPNRPPTISQPGFSAGPSSSSSLPPPASSKHKTTERQEKGDKLQKRPLIPFHHRPSVAEELCMEQDTPGQKLGLAGIDSSLEVSSSRKYDKQMAVPSRNTSKQMNLNPMDSPHSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYGNGLEL
2) GILMTGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPE
3) GTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTDVRQDNAAGRAGSGSLTQVTDLAPSLHDLDNIFDNSDDDELGAVSPALRSSKMPTVGTEDRPLGKDGRTAVPYPPTVADLQRMFPTPPSLEQHPAFSPV
4) IPPKYQTPPAAQGQATPGNAGPLASNSGSAVPPAGSAFNPTSNGSSANPAASSSAPGSSVPPVSSSSSAPGINQMSTTSSSGFSGSVGGQNPSTGGSSADRTQGNIGCGGDTEPGQSSAQPSQDGQESVTERERIGIPTEPDSA
5) SDKRWHSYCLPPSDDAEFRPPELQGERCDAKMEVNSESTALQ
6) SGASAGGHITVGQQGLGSVKDPSNCGMPLTPPTSPEQVLIGESGGTQSAVSHLGSQEGGMITMHSPKRSGKIPPKLH
7) VGSLADPDYLNTPQMNTPVTLNSAAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQ
434
2040
736
1525
629
297
1004
589
2088
880
1668
670
373
1101










Molecular Recognition Features






MoRF SequenceStartStop




1) KRFKIW
678
683