<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20923

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMDLAYVCEWEKWPRSTLCPSVPLACAWSCRNLIAFTTDLRNDDQDLTRMIHILDTEHPWDVHSIDSEHREAITCLEWDQSGSRLLSADADGQIKCWSMADHLANSWESPVGSLVEGDPIVALSWLHNGVKLALHVEKSGASSFGEKFSRVKFSPSLTLFGGKPMEGWIAVTVSGLVTVSLLKPSGQVLTSTESLCRLRGRVALADIAFTGGGNIVVATADGSSASPVQFYKVCVSVVSEKCRIDTEILPSLFMRCTTDLNRKDKFPAITHLKFLARDMSEQVLLCASSQTNSLVECWSLRKEGLPVNNIFQQISPMVGDKQPMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLGLALAFHDGSVHIVHRLSLQTMAVFYSSAAPRSVDEPAIKRPRTSGPAIHFKAMQLSWTSLALVGIDNHGKLNMLRISPSMGHTLDMSLALRHLLFLLEYCMVTGYDWWDILLHVQPSMVQSLVEKLHEEYTRQNAALQQVLSTRILAMKASLCKLSPCTVTRVCDYHAKLFLIAISSTLRSLLRPHFLNTPDKSPGDRLTEICSKITDVDIDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFVLYLLASLPNQGSPLRPGHSFLRDGTSLGILRELMVVIRIWGLLKPSCLPVYTATSDTQDSMSLLFRLLTKLWICCRDEGPTSEPDEALVDECCLLPSQLLIPSLDWLPVSDGLISRLQPKQPLRLQFGRAPTLPGSAAASQLDSLARAPGQPKIDHLRRLHLGAYPTEECKTCTRCGCVTMLRSPNKTTAVKQWEQRWIKNCLCGGLWRRMPLSCP
Length829
PositionTail
OrganismTrichechus manatus latirostris (Florida manatee)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Afrotheria> Sirenia> Trichechidae> Trichechus.
Aromaticity0.07
Grand average of hydropathy0.016
Instability index51.65
Isoelectric point7.70
Molecular weight92117.00
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
catalytic activity	GO:0003824	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20923
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     132.37|      44|     188|      71|     120|       1
---------------------------------------------------------------------------
   71-  120 (76.71/65.67)	AITCLEW...DQSGSRLL..SADADGQIKCWSM.ADHLanswesPVGSLVE......GD..PIV
  267-  324 (55.66/35.08)	AITHLKFlarDMSEQVLLcaSSQTNSLVECWSLrKEGL......PVNNIFQqispmvGDkqPMI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.31|      27|     132|      10|      36|       2
---------------------------------------------------------------------------
   10-   36 (53.26/28.59)	EKWPRSTLCPSVPLACAWSCRNLIAFT
  145-  171 (49.05/25.79)	EKFSRVKFSPSLTLFGGKPMEGWIAVT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      68.97|      15|      32|     731|     745|       5
---------------------------------------------------------------------------
  731-  745 (28.78/16.31)	QPK.QPL.RLQFGRAPT
  749-  763 (20.60/ 9.72)	SAA.ASQ.LDSLARAPG
  764-  780 (19.59/ 8.90)	QPKiDHLrRLHLGAYPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.51|      30|      35|     626|     658|       9
---------------------------------------------------------------------------
  626-  658 (50.13/44.33)	PLRPGHSFLRDGTSL..GILRELMVVIRIWGllkP
  662-  693 (51.38/36.75)	PVYTATSDTQDSMSLlfRLLTKLWICCRDEG...P
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20923 with Med16 domain of Kingdom Metazoa
Unable to open file!