<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20921
Description |
Mediator of RNA polymerase II transcription subunit 18 |
Sequence | MEAPPVTMMPVTGGTINMMEYLLQGSVLDHSLESLIHRLRGLCDNMEPETFLDHEMVFLLKGQQASPFVLRGRRSMDRTGAPWHLRYLGQPEMGDKNRHALVRNCVDIATSENLTDFLMEMGFRMDHEFVAKGHLFRKGIMKIMVYKIFRILVPGNTDSIEALSLSYLVELSVVAPAGQDMVSDDMRNFAEQLKPLVHLEKIDPKRLM |
Length | 208 |
Position | Head |
Organism | Trichechus manatus latirostris (Florida manatee) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Afrotheria> Sirenia> Trichechidae> Trichechus.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.118 |
Instability index | 38.66 |
Isoelectric point | 6.06 |
Molecular weight | 23718.52 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364150
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP20921
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 220.42| 60| 64| 9| 72| 1
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9- 63 (88.19/42.61) ........................MPVTGGTINM..MEYLLQGSVLDHSLESLI.HRL......RGLCDNMEPETFLDHEMVFLLKGQ
68- 128 (82.97/44.81) FVLRG................rrsMDRTGAPWH...LRYLGQPEMGDKNRHALV.RNCvdiatsENLTD......FL.MEMGFRMDHE
129- 200 (49.25/18.77) FVAKGhlfrkgimkimvykifrilVPGNTDSIEAlsLSYLVELSVVAPAGQDMVsDDM......RNFAEQLKPLVHLE..........
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