<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20919

Description mediator of RNA polymerase II transcription subunit 14
SequenceMAPVQLENHQLVPPGGGGSGGPASAPAPPPPGAAVAAAAAAAASPGYRLSSLIEFLLHRAYSELMVLTDLLPRKSDVERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDVPWRLLKLEILVEDKETGDGRALVHSMQINFIHQLVQSRLFADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIKIDENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQKLQELKAILRGFNANENSSIETALPALVVPILEPCSSSECLHIFVDLHSGMFQLMLYGLDQATLDDMEKSVNDDMKQIIPWIQQLKFWLGQQRCKQSIKHLPTISSETLQLSNYSTHPIGNLSKNKLFIKLTRLPQYYIVVEMLEVPSKPTQLVYKYYFLSVNNTDRDDSPVTALVLEQFKENVQDVAVRTKAGIQPRTGAKRKLSGDLCPVEPKKTKRSGEMCAFNKVLAHFVAMCDTNMPFVGLRLELSNLEIPHQGVQMEGDGFSHAIRLLKIPPCKGVNEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWNSIARLYECVLEFARSLPDIPAHLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSIHQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPQPPPQQQPFPKQPGSSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPATRMPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTSVPPQEPVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQGECTIFAAVRDLMANLTLPPGGRP
Length1454
PositionTail
OrganismTrichechus manatus latirostris (Florida manatee)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Afrotheria> Sirenia> Trichechidae> Trichechus.
Aromaticity0.06
Grand average of hydropathy-0.178
Instability index51.78
Isoelectric point8.91
Molecular weight160509.51
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20919
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     296.14|      56|      56|    1008|    1063|       1
---------------------------------------------------------------------------
 1008- 1063 (107.17/49.33)	PFPKQ.PGSSGAYPLTSPPTSYHSTVN..QSPSMMHTQSPGN..LHA.A..SSPSGALRAPSPA
 1064- 1097 (61.20/24.77)	SF..........VP.TPPPSS..............HGISIGP..GAS.F..ASPHGTLDPSSPY
 1100- 1151 (74.84/32.06)	VSPS...GRAGNWP.GSPQVSGPSPAT..RMPGM....SPANpsLHSpV..PDASHSPRAGTSS
 1159- 1206 (52.93/20.35)	PPPRKlPQRSWAASI..PTILTHSALNilLLPSPTPGLVPG...LAG.SylCSP..........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.64|      30|      32|     244|     273|       2
---------------------------------------------------------------------------
  244-  273 (48.89/32.46)	RLLKLEILVEDKETGDGRALVH....SMQINFIH
  274-  307 (45.75/29.89)	QLVQSRLFADEKPLQDMYNCLHsfclSLQLEVLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.06|      24|      24|    1363|    1386|       3
---------------------------------------------------------------------------
 1362- 1385 (39.65/17.07)	KMLFFL..QLTQKTSVPPQEPVSIIV
 1386- 1411 (34.41/13.91)	PIIYDMasGTTQQADIPRQQNSSVAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     155.94|      51|     506|     327|     377|       5
---------------------------------------------------------------------------
  327-  377 (92.73/66.19)	YHAGKCLSLSV.WN..QQ.......VLGRKTGTASVHKVTI.KIDE..N...DVSKPLQIFHDPPLP
  810-  876 (63.21/42.46)	YGTTKGSSISIqWNsiHQkfhislgTVGPNSGCSNCHNTILhQLQEmfNktpNVVQLLQVLFDTQAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     132.18|      54|     506|     147|     217|       6
---------------------------------------------------------------------------
   28-   73 (32.63/11.05)	PPPPGAAVAAAAAaaaspgyrLSSLIEFLLHRayselMVLTDLLPR.................................................................................................
  147-  168 (14.98/17.36)	..............................................ksdverkieivqfasrtrqlfvrllalvkwannagkvekcamissfldqqailfvdtadrlaslardalvharLpSFAIPYAIDVLTT..GSYPRLP
  177-  242 (84.57/63.12)	PPDPITKIEKQAT........LHQLNQILRHR.....LVTTDLPPQ...............................................................lanltvangrV.KFRVEGEFEATLTvmGDDPDVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.60|      19|      32|      77|      95|      11
---------------------------------------------------------------------------
   77-   95 (31.17/26.70)	VERKIEIVQFASRTRQLFV
  110-  128 (32.43/28.14)	VEKCAMISSFLDQQAILFV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.60|      14|      35|    1247|    1261|      12
---------------------------------------------------------------------------
 1247- 1261 (21.47/17.89)	LKCRVALSP.KTNqTL
 1285- 1299 (22.14/12.65)	FETRVAGPPfKAN.TL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.56|      26|      35|     509|     534|      14
---------------------------------------------------------------------------
  509-  534 (45.45/28.44)	HLPT..ISSETLQLSNYSTHPIGN...LSKN
  542-  572 (34.11/19.36)	RLPQyyIVVEMLEVPSKPTQLVYKyyfLSVN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20919 with Med14 domain of Kingdom Metazoa
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